Ngwa nke ọgwụ Excipients HPMC

Site n'ịbawanye nyocha nke usoro nnyefe ọgwụ na ihe siri ike chọrọ, ihe mgbakwunye ọgwụ ọhụrụ na-apụta, n'ime nke hydroxypropyl methylcellulose na-eji ọtụtụ ebe. Akwụkwọ a na-enyocha ngwa ụlọ na nke mba ọzọ nke hydroxypropyl methylcellulose. Usoro mmepụta na uru na ọghọm ya, nkà na ụzụ akụrụngwa na atụmanya imezi ụlọ, yana ngwa ya n'ọhịa nke ihe ndị na-emepụta ọgwụ.
Okwu ndị dị mkpa: ihe ndị na-emepụta ọgwụ; hydroxypropyl methylcellulose; mmepụta; ngwa

1 Okwu mmalite
Ndị na-emepụta ọgwụ na-ezo aka n'ozuzu okwu maka ihe ndị ọzọ ọgwụ ndị ọzọ agbakwunyere na nkwadebe ma e wezụga ọgwụ bụ isi iji dozie nhazi, nnweta na nchekwa nke nkwadebe na usoro mmepụta na ịmepụta nkwadebe. Ihe mgbakwunye ọgwụ dị oke mkpa na nkwadebe ọgwụ. E nwere ọtụtụ ụdị ọgwụ excipients na anụ ụlọ na mba ọzọ nkwadebe, ma n'oge na-adịbeghị anya, chọrọ maka ịdị ọcha, mgbasa, kwụsie ike, bioavailability na vivo, mma nke ọgwụgwọ mmetụta na Mbelata mmetụta nke ọgwụ na-na-elu na elu. , na-eme ka mpụta ngwa ngwa nke ihe ọhụrụ na usoro nyocha iji meziwanye arụmọrụ nke nkwadebe ọgwụ na ịdị mma nke iji. Ọnụ ọgụgụ dị ukwuu nke ihe atụ data na-egosi na hydroxypropyl methylcellulose nwere ike imezu ihe ndị a dị n'elu dị ka ihe na-emepụta ọgwụ dị elu. Ọnọdụ ugbu a nke nyocha na mmepụta nke mba ọzọ na ntinye ya n'ọhịa nke nkwadebe ọgwụ na-achịkọta ọzọ.

2 Nyochaa akụrụngwa nke HPMC
HPMC bụ ọcha ma ọ bụ ntakịrị odo, enweghị isi, enweghị isi, ntụ ntụ na-adịghị egbu egbu nke enwetara site na etherification nke cellulose alkali, propylene oxide na alkyl chloride. Na-agbaze ngwa ngwa na mmiri n'okpuru 60 ° C na 70% ethanol na acetone, isoacetone, na dichloromethane ngwakọta ihe mgbaze; HPMC nwere ike kwụsie ike, tumadi pụtara: mbụ, ya aqueous ngwọta enweghị ụgwọ na adịghị meghachi omume na metal salts ma ọ bụ ionic organic ogige; nke abụọ, ọ na-eguzogidekwa acids ma ọ bụ ntọala. Dịtụ kwụsiri ike. Ọ bụ nkwụsi ike nke HPMC na-eme ka ogo ọgwụ ndị nwere HPMC dị ka ihe enyemaka kwụsie ike karịa ndị nwere ihe mgbakwunye ọdịnala. Na toxicology ọmụmụ nke HPMC dị ka excipients, e gosiri na HPMC agaghị metabolized na ahu, na ọ dịghị eso na ahụ mmadụ si metabolism. Inye ike, enweghị nsi na mmetụta dị n'akụkụ ọgwụ, ihe mgbakwunye ọgwụ nchekwa.

3 Nnyocha maka mmepụta ụlọ na nke mba ọzọ nke HPMC
3.1 Nyochaa teknụzụ mmepụta nke HPMC n'ụlọ na ná mba ọzọ
Ka mma nagide mgbe-agbasa na-abawanye chọrọ nke ọgwụ nkwadebe n'ụlọ na mba ọzọ, mmepụta technology na usoro nke HPMC na-na-mgbe niile na-emepe emepe na tortuous na ogologo ụzọ. Enwere ike kewaa usoro mmepụta nke HPMC n'ime usoro batch na usoro na-aga n'ihu. Isi edemede. A na-ejikarị usoro a na-aga n'ihu na mba ọzọ, ebe a na-ejikarị usoro nhazi na China. Nkwadebe nke HPMC gụnyere usoro nke nkwadebe alkali cellulose, mmeghachi omume etherification, nchacha ọgwụgwọ, na ọgwụgwọ ngwaahịa emechara. N'ime ha, e nwere ụdị ụzọ abụọ nke usoro maka mmeghachi omume etherification. : Usoro nke gas na usoro mmiri mmiri. N'ikwu okwu n'otu n'otu, usoro gas gas nwere uru nke nnukwu mmepụta ikike, obere mmeghachi omume okpomọkụ, obere oge mmeghachi omume, na njikwa mmeghachi omume ziri ezi, mana nrụgide mmeghachi omume dị ukwuu, ntinye ego buru ibu, ma ozugbo nsogbu mere, ọ dị mfe. na-ebute nnukwu ihe mberede. Usoro mmiri mmiri n'ozuzu nwere uru nke nrụgide mmeghachi omume dị ala, ihe ize ndụ dị ala, ọnụ ahịa ntinye ego dị ala, njikwa mma dị mfe, na ngbanwe dị iche iche; ma n'otu oge ahụ, reactor chọrọ site na mmiri mmiri usoro usoro enweghị ike ịbụ oke ibu, nke na-amachikwa mmeghachi omume ike. E jiri ya tụnyere usoro gas gas, oge mmeghachi omume dị ogologo, ikike mmepụta dị ntakịrị, ngwá ọrụ achọrọ dị ọtụtụ, ọrụ ahụ dị mgbagwoju anya, na njikwa akpaaka na izi ezi dị ala karịa usoro gas gas. Ka ọ dị ugbu a, mba ndị mepere emepe dị ka Europe na United States na-ejikarị usoro ikuku gas eme ihe. Enwere nnukwu ihe achọrọ n'ihe gbasara teknụzụ na itinye ego. N'ikpe ikpe site na ọnọdụ dị na mba anyị, usoro mmiri mmiri na-emekarị. Agbanyeghị, enwere ọtụtụ mpaghara na China ndị na-aga n'ihu na-emegharị na imepụta teknụzụ, mụta ihe site na ọkwa dị elu nke mba ofesi, wee malite usoro na-aga n'ihu. Ma ọ bụ ụzọ ewebata usoro gas-phase nke mba ọzọ.
3.2 Mmepụta teknụzụ mmepụta nke HPMC ụlọ
HPMC na obodo m nwere nnukwu ikike mmepe. N'okpuru ndị dị otú ahụ mma ohere, ọ bụ ihe mgbaru ọsọ nke onye ọ bụla na-eme nchọpụta ịnọgide na-emeziwanye mmepụta nkà na ụzụ nke HPMC na ibelata ọdịiche dị n'etiti anụ ụlọ HPMC ụlọ ọrụ na mba ọzọ elu mba. Usoro HPMC Njikọ ọ bụla n'ime usoro njikọ ahụ bara ezigbo uru na ngwaahịa ikpeazụ, n'ime nke mmeghachi omume alkalization na etherification [6] bụ ihe kacha mkpa. Ya mere, enwere ike ịme teknụzụ mmepụta HPMC ụlọ dị ugbu a site na ntụziaka abụọ a. Mgbanwe. Nke mbụ, a ga-eme nkwadebe nke cellulose alkali na obere okpomọkụ. Ọ bụrụ na a kwadebere ngwaahịa viscosity dị ala, enwere ike ịgbakwunye ụfọdụ oxidants; ọ bụrụ na a kwadebere ngwaahịa viscosity dị elu, enwere ike iji usoro nchebe gas na-enweghị isi mee ihe. Nke abuo, a na-eme mmeghachi omume etherification na okpomọkụ dị elu. Tinye toluene n'ime ngwa etherification tupu oge eruo, zipu cellulose alkali n'ime akụrụngwa na mgbapụta, tinyekwa ụfọdụ isopropanol dị ka mkpa. Belata oke mmiri siri ike. Na-eji a kọmputa akara usoro, nke nwere ike ngwa ngwa nzaghachi okpomọkụ, Usoro parameters dị ka nrụgide na pH na-akpaghị aka gbanwee. N'ezie, mmelite nke teknụzụ mmepụta HPMC nwekwara ike imeziwanye site na ụzọ usoro, iji ihe eji eme ihe, nchacha ọgwụgwọ na akụkụ ndị ọzọ.

4 Ngwa nke HPMC na ngalaba ọgwụ
4.1 Iji HPMC eme ihe n'ịkwadebe mbadamba ihe na-adịgide adịgide
N'ime afọ ndị na-adịbeghị anya, na-aga n'ihu na-amụbawanye nyocha usoro nnyefe ọgwụ, mmepe nke HPMC nke nwere viscosity dị elu na ntinye nke nkwadebe ntọhapụ adọtala mmasị dị ukwuu, na mmetụta nkwụsị na-adịgide adịgide dị mma. N'iji ya tụnyere, a ka nwere nnukwu oghere na ntinye nke mbadamba nkume matriks ntọhapụ na-adịgide adịgide. Dịka ọmụmaatụ, mgbe ị na-atụnyere HPMC nke ụlọ na nke mba ọzọ maka mbadamba nifedipine na-ahapụ ya yana dị ka matrix maka mbadamba propranolol hydrochloride na-ahapụ matrix, a na-achọpụta na ojiji nke HPMC nke ụlọ na nkwado ntọhapụ na-achọwanye ọganihu iji na-aga n'ihu na-emeziwanyewanye. ọkwa nke nkwadebe ụlọ.
4.2 Ngwa nke HPMC na ndim nke mmanu ogwu
N'ihi mkpa nke nyocha ma ọ bụ ọgwụgwọ nke ụfọdụ ngwaọrụ ahụike taa, mgbe ị na-abanye ma ọ bụ na-ahapụ akụkụ ahụ na anụ ahụ mmadụ, elu ngwaọrụ ahụ ga-enwerịrị ụfọdụ ihe na-enye mmanụ, HPMC nwekwara ụfọdụ ihe na-esi ísì ụtọ. E jiri ya tụnyere mmanụ mmanụ ndị ọzọ, HPMC nwere ike iji ya mee ihe dị ka ọgwụ mmanu mmanu , nke nwere ike ọ bụghị naanị ibelata ihe eji eme ihe, ma na-egbo mkpa nke mmanye ọgwụ na-ebelata ego.
4.3 Ngwa nke HPMC dị ka ihe nkiri nkwakọ ngwaahịa mmiri na-edozi mmiri na ihe mkpuchi ihe nkiri na ihe na-emepụta ihe nkiri.
Tụnyere ihe mbadamba ọdịnala ndị ọzọ mkpuchi, HPMC nwere uru doro anya n'ihe gbasara ike ike, friability na nnabata mmiri. Enwere ike iji HPMC nke ọkwa viscosity dị iche iche dị ka nkwakọ ngwaahịa na-agbaze mmiri maka mbadamba na ọgwụ. Enwere ike iji ya dị ka ihe nkiri nkwakọ ngwaahịa maka usoro ihe mgbaze organic. Enwere ike ịsị na HPMC bụ ihe mkpuchi ihe nkiri kachasị ewu ewu na obodo m. Tụkwasị na nke a, a pụkwara iji HPMC mee ihe dị ka ihe na-emepụta ihe nkiri na onye na-emepụta ihe nkiri, na ihe nkiri nkwakọ ngwaahịa na-egbochi oxidative mmiri nke dabeere na HPMC na-ejikarị na-echekwa nri, karịsịa mkpụrụ osisi.
4.4 Ngwa nke HPMC dị ka ihe mkpuchi capsule
A pụkwara iji HPMC mee ihe maka ịkwadebe shei capsule. The uru nke HPMC capsules bụ na ha imeri cross-njikọ mmetụta nke gelatin capsules, nwere ezi ndakọrịta na ọgwụ ọjọọ eme ihe, nwere elu kwụsie ike, nwere ike ịgbanwe na ịchịkwa ntọhapụ omume nke ọgwụ ọjọọ, melite ọgwụ àgwà, Ọ nwere uru nke kwụsiri ike ọgwụ ntọhapụ. usoro. Na-arụ ọrụ, HPMC capsules nwere ike dochie kpamkpam gelatin capsules dị adị, na-anọchi anya ọdịnihu mmepe direction nke ike capsules.
4.5 Ngwa nke HPMC dị ka onye nkwusioru
A na-eji HPMC dị ka onye na-akwụsịtụ, yana mmetụta nkwụsị ya dị mma. Na nnwale na-egosi na iji ihe ndị ọzọ polymer na-emekarị dị ka onye na-akwụsịtụ iji dozie nkwusioru akọrọ na HPMC dị ka onye na-emechi anya iji kwadebe nkwusioru akọrọ. Nkwụsịtụ akọrọ dị mfe ịkwadebe ma nwee nkwụsi ike dị mma, na nkwụsị nke a kpụrụ na-emezu ihe ndị a chọrọ nke ihe ngosi dị iche iche dị mma nke nkwusioru akọrọ. Ya mere, a na-ejikarị HPMC eme ihe dị ka onye na-akwụsịtụ maka nkwadebe anya.
4.6 Ngwa nke HPMC dị ka ihe mgbochi, onye na-ahapụ ngwa ngwa na porogen
Enwere ike iji HPMC dị ka onye na-egbochi igbochi, onye na-ahapụ ya na onye na-emepụta pore iji gbuo oge na ịchịkwa ntọhapụ ọgwụ. N'oge a, a na-ejikwa HPMC n'ọtụtụ ebe na nkwadebe mwepụta na nkwadebe ngwakọta nke ọgwụ ndị China ọdịnala, dị ka mbadamba nkume Tianshan Snow Lotus na-adịgide adịgide. Ngwa, mmetụta ntọhapụ ya na-adịgide adịgide dị mma, na usoro nkwadebe dị mfe ma kwụsie ike.
4.7 Ngwa nke HPMC dị ka thickener na colloid-echebe gluu
Enwere ike iji HPMC dị ka thickener [9] iji mepụta colloid nchebe, na nyocha nnwale ndị dị mkpa egosila na iji HPMC dị ka ihe na-ekpo ọkụ nwere ike ịkwalite nkwụsi ike nke carbon na-arụ ọrụ ọgwụ. Dịka ọmụmaatụ, a na-ejikarị ya na nkwadebe nke pH-sensitive levofloxacin hydrochloride ophthalmic gel dị njikere iji. A na-eji HPMC eme ihe dị ka thickener.
4.8 Ngwa nke HPMC dị ka bioadhesive
Ihe nrapado eji na teknụzụ bioadhesion bụ ogige macromolecular nwere njirimara bioadhesive. Site na ịrapagidesi ike na mucosa eriri afọ, ọnụ mucosa na akụkụ ndị ọzọ, ọganihu na njigide nke kọntaktị dị n'etiti ọgwụ na mucosa na-ewusi ike iji nweta mmetụta ọgwụgwọ ka mma. . Ọnụ ọgụgụ dị ukwuu nke ihe atụ ngwa na-egosi na HPMC nwere ike imezu ihe ndị a chọrọ n'elu dị ka bioadhesive.
Tụkwasị na nke ahụ, a pụkwara iji HPMC mee ihe dị ka ihe mgbochi mmiri ozuzo maka gels topical na microemulsifying usoro, na na ụlọ ọrụ PVC, HPMC nwere ike iji dị ka ihe nchebe mgbasa na VCM polymerization.

5 Nkwubi okwu
N'otu okwu, HPMC ejirila ya mee ihe na nkwadebe ọgwụ na akụkụ ndị ọzọ n'ihi ihe pụrụ iche physicochemical na ndu. Agbanyeghị, HPMC ka nwere ọtụtụ nsogbu na nkwadebe ọgwụ. Gịnị bụ kpọmkwem ọrụ HPMC na ngwa; otu esi achọpụta ma ọ nwere mmetụta ọgwụ; Kedu àgwà ọ nwere na usoro ntọhapụ ya, wdg. Enwere ike ịhụ na ebe a na-ejikarị HPMC eme ihe, ọ dị mkpa ka edozi nsogbu ndị ọzọ ngwa ngwa. Na ndị ọzọ na-eme nnyocha na-arụ ọtụtụ ọrụ maka mma ngwa nke HPMC na nkà mmụta ọgwụ, si otú nọgidere na-akwalite mmepe nke HPMC na ubi nke ọgwụ excipients.