Hydroxypropyl Methylcellulose (HPMC) bụ ọkara synthetic, inert, polymer viscosity dị elu nke a na-ejikarị eme ihe n'ụdị ọgwụ. Njirimara anụ ahụ na kemịkal pụrụ iche na-eme ka ọ bụrụ ihe dị mkpa dị mkpa na ụlọ ọrụ na-emepụta ọgwụ, yana imepụta ihe nkiri, nkwụsi ike, nkwụsi ike na ịdị ndụ.
Njirimara ndị bụ isi nke HPMC
A na-eme HPMC site na methylating na hydroxypropylating cellulose. Ọ nwere ezigbo mmiri solubility na thermoplasticity, ma na-agbaze ngwa ngwa na mmiri oyi iji mepụta ngwọta colloidal transperent. Enwere ike ịchịkwa solubility na viscosity ya site n'ịgbanwe ogo nke nnọchi na ogo polymerization, nke na-enye HPMC ohere izute mkpa nke usoro ọgwụ dị iche iche.
Mpaghara ngwa
1. ọgwụ na-achịkwa-ahapụ
A na-eji HPMC eme ihe n'ọtụtụ ebe n'ịkwadebe ọgwụ ndị a na-achịkwa achịkwa. N'ihi solubility ya na mmiri na ike ịmepụta gels, HPMC nwere ike ịhazi ntọhapụ nke ọgwụ. Njirimara ọzịza ya na eriri afọ na-enye ohere iji nwayọọ nwayọọ wepụta ọgwụ ahụ n'ime oge a kapịrị ọnụ, na-achịkwa mkpokọta ọgwụ plasma nke ọma, na-ebelata ugboro ole ọgwụ, na imeziwanye nnabata onye ọrịa.
2. Binders na disintegrants maka mbadamba nkume
Dị ka ihe nkedo na disintegrant maka mbadamba nkume, HPMC nwere ike welie n'ibu ike nke mbadamba nkume mgbe n'ịhụ na mbadamba na-agbasasị na hapụ ọrụ na-arụ ọrụ n'oge kwesịrị ekwesị. Ngwunye ya na-enyere aka ijikọta ụmụ irighiri ọgwụ ahụ iji mepụta mbadamba nkume siri ike, ebe ọzịza ya na-ekwe ka mbadamba nkume ndị ahụ gbasaa ngwa ngwa na mmiri.
3. Ihe mkpuchi ihe nkiri
HPMC bụ ihe dị mkpa maka ịkwadebe mkpuchi ihe nkiri ọgwụ ọgwụ. Enwere ike iji ya dị ka ihe mkpuchi ihe nkiri nchebe iji chebe ọgwụ ahụ site na mmiri mmiri, oxygen na ìhè, si otú a na-eme ka nkwụsi ike nke ọgwụ ahụ dịkwuo mma. Na mgbakwunye, HPMC nwekwara ike iji dị ka mkpuchi enteric iji chebe ọgwụ ahụ ka a tọhapụrụ ya na afọ ma hụ na a na-etinye ọgwụ ahụ n'ime eriri afọ.
4. Nkwadebe anya
Na nkwadebe anya, a na-ejikarị HPMC akwadebe anya mmiri na-edozi anya na mmiri anya. Nnukwu viscosity ya na biocompatibility na-enyere ya aka ịmepụta ihe nkiri nchebe n'elu anya, na-ete mmanu anya, ma wepụ ihe mgbaàmà anya nkụ.
5. Capsules
Enwere ike iji HPMC dozie capsules siri ike na capsules dị nro. N'iji ya na capsules gelatin ọdịnala, capsules HPMC nwere nkwụsi ike kemịkalụ ka mma, adịghị mfe ịmịkọrọ mmiri, ma na-enwekwa enyi karịa ndị anaghị eri anụ na ndị kwere ekwe okpukpe.
Ihe na-emetụta
1. Viscosity
Viscosity nke HPMC bụ otu n'ime ihe dị mkpa na-egosi arụmọrụ ya. Enwere ike iji HPMC nwere viscosity dị elu maka ọgwụ ndị a na-achịkwa na-ahapụ ya na nkwadebe mkpuchi ihe nkiri, ebe HPMC nwere viscosity dị ala dabara adaba maka iji ya dị ka ihe nkedo na disintegrant.
2. Degree nke nnọchi
Ogo nke nnọchi (DS) na molar nnọchi (MS) nke HPMC na-emetụta ozugbo ike ya na ike imepụta gel. Ndozi kwesịrị ekwesị nke ogo nnọchi anya nwere ike ịkwalite mmetụta ngwa nke HPMC n'ụdị ọgwụ dị iche iche.
3. Ihe gbasara gburugburu ebe obibi
Ọrụ nke HPMC na-emetụtakwa ihe gburugburu ebe obibi dị ka okpomọkụ, uru pH na ike ionic. Ekwesịrị ịtụle ihe ndị a mgbe ị na-akwadebe usoro ọgwụ iji hụ na HPMC na-arụ ọrụ nke ọma.
Hydroxypropyl methylcellulose (HPMC), dị ka a multifunctional, elu-arụmọrụ ọgwụ excipient, na-eji n'ọtụtụ ebe dị ka ọgwụ na-achịkwa ntọhapụ, mbadamba, ihe nkiri mkpuchi, nkwadebe ophthalmic na capsules. Site n'ịgbanwe viscosity ya na ogo nke nnọchi, ọ nwere ike gboo mkpa nke usoro ọgwụ dị iche iche ma mee ka nkwụsi ike na bioavailability nke ọgwụ dịkwuo mma. Site na ọganihu teknụzụ ọgwụ na-aga n'ihu, atụmanya ngwa nke HPMC ga-aba ụba.
Oge nzipu: Jul-11-2024