Ngwa nke HPMC K4M na ụlọ ọrụ ọgwụ

HPMC K4M (hydroxypropyl methylcellulose K4M) bụ ihe a na-ahụkarị ọgwụ excipient nke a na-ejikarị na ụlọ ọrụ na-emepụta ọgwụ, karịsịa na mbadamba ntọhapụ na-adịgide adịgide, nkwadebe ntọhapụ na-achịkwa na nkwadebe siri ike ọnụ ndị ọzọ.

Njirimara ndị bụ isi nke HPMC K4M

HPMC K4M bụ ọkwa nkịtị nke Hydroxypropyl Methylcellulose (HPMC). HPMC bụ ọkara sịntetik, elu molekul arọ multifunctional polymer ihe mere si chemically gbanwetụrụ cellulose na ezi anụ ahụ na kemịkal Njirimara, dị ka magburu onwe ndim, gelling, film-akpụ na nrapado Njirimara.

A na-eji HPMC K4M eme ihe n'ọhịa ọgwụ n'ihi viscosity ya dị oke mma na ihe na-emepụta ihe nkiri. "K" na K4M na-anọchi anya cellulose viscosity dị elu, na "4M" pụtara na viscosity ya dị ihe dị ka 4000 centipoise (a tụrụ na ngwọta 2% nke mmiri mmiri).

Ngwa isi nke HPMC K4M na ụlọ ọrụ ọgwụ

1. Ngwa na nkwado nkwado nkwado

Ọrụ bụ isi nke HPMC K4M na nkwado ntọhapụ na-adịgide adịgide bụ ije ozi dị ka ihe matriks a na-ejikwa chịkwaa. Hydrophilicity ya pụrụ iche na ike imepụta gel na-eme ka ọ bụrụ otu n'ime ihe ndị a na-ejikarị eme ihe na sistemụ ntọhapụ ọgwụ na-adịgide adịgide. HPMC K4M nwere ike ịmịnye mmiri ngwa ngwa ma zaa mgbe ọ na-akpakọrịta na mmiri, wee mepụta akwa gel n'elu mbadamba nkume ahụ, na-egbu oge ntọhapụ nke ọgwụ ahụ, si otú ahụ nweta mmetụta ntọhapụ a na-achịkwa.

Ngwongwo a dabara adaba maka mbadamba ụrọ na-ahapụ ya, dị ka ọgwụ mgbochi hypertensive, ọgwụ mgbochi ọrịa shuga, na analgesics. Site na iji HPMC K4M, enwere ike ịhapụ ọgwụ ahụ mgbe niile n'ime ahụ, na-edobe itinye uche ọgwụ ọbara mgbe niile, na-ebelata oge nke ọgwụ, yana melite nnabata onye ọrịa.

2. Capsules na ihe mkpuchi

HPMC K4M, dị ka ihe mkpuchi, nwere ike ịmepụta ihe nkiri nchebe n'elu nkwadebe ahụ. Ihe nkiri ahụ nwere ihe mgbochi dị mma, nke nwere ike igbochi ọgwụ ahụ n'ụzọ dị irè site na mmiri, oxidation ma ọ bụ ìhè, na-agbatịkwu nkwụsi ike na ndụ ndụ nke ọgwụ ahụ. N'adịghị ka gelatin ọdịnala, HPMC bụ ihe ọkụkụ sitere na ya, yabụ ọ dabara maka ndị anaghị eri anụ na ndị ọrịa nwere ihe nfụkasị ahụ sitere na anụmanụ.

HPMC K4M nwekwara ike iji dị ka ihe nkwadebe maka capsule shells, dochie gelatin capsules, na-eji na encapsulation nke onye anaghị eri anụ capsules na mmetụta uche ọgwụ, na ezi biocompatibility na nchekwa.

3. Dị ka thickener na ihe nkedo

Na ọgwụ ụlọ ọrụ, HPMC K4M na-ọtụtụ-eji na mmiri granulation Filiks dị ka ihe nkedo na-akwalite guzobe nke ahụ. Ngwongwo njikọ ya dị mma nwere ike hụ na ihe ndị ahụ nwere ike siri ike na nkesa, na-eme ka mbadamba nkume ndị ahụ nwee ike ịgbasa ngwa ngwa ma hapụ ọgwụ ahụ mgbe ejiri ya. Na mgbakwunye, HPMC K4M nwekwara ike iji dị ka thickener na mmiri mmiri preparations, dị ka nkwusioru na ophthalmic preparations, dịkwuo viscosity na nkwụsi ike nke nkwadebe.

4. Stabilizer na ihe nchebe

HPMC K4M nwere ike na-eme ihe dị ka a stabilizer na-echebe gị n'ụlọnga na ụfọdụ nkwadebe, karịsịa na multiphase usoro dị ka emulsions na suspensions. Ike ya na-eme ka ọ sie ike na gel-forming nwere ike igbochi ọgwụ ahụ ka ọ dozie ma ọ bụ stratifying n'oge nchekwa, na-eme ka ịdị n'otu na nkwụsi ike nke nkwadebe ahụ. Na mgbakwunye, na ụfọdụ ọgwụ nje ma ọ bụ ọgwụ protein, HPMC K4M nwere ike iji dị ka ihe nchebe iji gbochie protein ahụ ka ọ ghara imebi ma ọ bụ mebie ya n'oge nkwadebe ma ọ bụ nchekwa, na-ahụ na ọrụ ndu nke ọgwụ ahụ.

5. Mucosal absorption enhancer

N'afọ ndị na-adịbeghị anya, ọmụmụ egosila na enwere ike iji HPMC K4M dị ka ihe nkwalite mmịpụta nke mucosal iji nyere aka melite bioavailability nke ụfọdụ ọgwụ siri ike na-amị. Dịka ọmụmaatụ, site na ijikọ na HPMC K4M, ụfọdụ protein na ọgwụ peptide nwere ike ịba mma na saịtị mucosal dị ka oghere ọnụ, oghere imi ma ọ bụ ikensi, na-ezere ụzọ ịgba ọgwụ ọdịnala na inye ụzọ nchịkwa dị mfe na nke na-adịghị emerụ ahụ.

6. Ọrụ nke ịhazi ntọhapụ ọgwụ

HPMC K4M nwere ike ọ bụghị naanị ka a ga-eji dị ka otu matriks ntọhapụ a na-achịkwa, kamakwa enwere ike iji ya na ihe ntọhapụ ndị ọzọ a na-achịkwa (dị ka carbomer, ethyl cellulose, wdg) iji dozie ntọhapụ ọgwụ na synergistically. Site na-agbanwe ịta, molekụla arọ ma ọ bụ ruru nke HPMC K4M na ndị ọzọ excipients, pharmaceutical usoro injinia nwere ike n'ụzọ ziri ezi gbanwee ntọhapụ ọnụego nke ọgwụ izute ọgwụgwọ mkpa dị iche iche ọgwụ.

Uru nke HPMC K4M na ọgwụ

Ezigbo nchekwa na biocompatibility: HPMC K4M bụ ihe na-adịghị egbu egbu, nke na-adịghị ewe iwe, na isi iyi ya bụ cellulose eke, nke kwesịrị ekwesị maka iji ogologo oge mee ihe. Ebe ọ bụ na HPMC K4M anaghị adabere na nbibi nke enzyme intestinal, ụzọ metabolic ya n'ime ahụ dị nro, na-ebelata ihe ize ndụ nwere ike ịnweta.

Ọ dị mfe iji: HPMC K4M nwere ike ịgbaze na mmiri oyi na mmiri ọkụ, na ngwọta nwere ezigbo nkwụsi ike ma dị mfe iji. Ikike imepụta ihe nkiri ya na ike imepụta gel na-enye ya nhazi usoro dị mma na usoro ọgwụ.

Ngwa dịgasị iche iche: HPMC K4M abụghị naanị maka nkwadebe siri ike nke ọnụ, kamakwa maka ụdị ọgwụgwọ ndị ọzọ dị iche iche, dị ka nkwadebe n'elu, nkwadebe anya, injections na nkwadebe inhalation. 

Dị ka a multifunctional pharmaceutical excipient, HPMC K4M nwere ọnọdụ dị mkpa na ụlọ ọrụ ọgwụ na ya magburu onwe anụ ahụ na kemịkal Njirimara na a dịgasị iche iche nke ngwa ndapụta. Ọ nwere mmetụta dị ịrịba ama n'ọtụtụ akụkụ dị ka nkwadebe nkwado na-adịgide adịgide, ihe ndị na-egbuke egbuke, ihe mkpuchi, ihe nkwụsịtụ, wdg, karịsịa maka nkwadebe nke mbadamba nkume na-adịgide adịgide, ọ nwere uru na-enweghị atụ. Site na ọganihu nke teknụzụ ọgwụ na-aga n'ihu, atụmanya ngwa nke HPMC K4M ga-aba ụba, na ọnọdụ ya na nkwadebe ọgwụ ọhụrụ ga-aga n'ihu.