Hydroxypropyl cellulose, ihe mgbakwunye ọgwụ, na-ekewa n'ime hydroxypropyl cellulose dị ala (L-HPC) na hydroxypropyl cellulose dị elu dochie anya (H-HPC) dịka ọdịnaya nke hydroxypropoxy nọchiri anya ya. L-HPC swells n'ime a colloidal ngwọta na mmiri, nwere Njirimara nke adhesion, film e guzobere, emulsification, wdg, na tumadi eji dị ka a disintegrating gị n'ụlọnga na ihe nkedo; ebe H-HPC bụ soluble na mmiri na ihe dị iche iche organic solvents na ụlọ okpomọkụ, na nwere ezigbo thermoplasticity. , ịdị n'otu na ihe na-emepụta ihe nkiri, ihe nkiri a kpụrụ akpụ siri ike, na-egbuke egbuke, na-agbanwe agbanwe, a na-ejikarị ya eme ihe dị ka ihe na-emepụta ihe nkiri na ihe mkpuchi. Ngwa a kapịrị ọnụ nke hydroxypropyl cellulose na nkwadebe siri ike ka ewebata ugbu a.
1. Dị ka a disintegrant maka siri ike nkwadebe dị ka mbadamba nkume
Elu nke ala dochie anyahydroxypropyl cellulosekristal ahụ na-ahaghị nhata, nwere ọdịdị ihu igwe dị ka nkume doro anya. Ọdịdị elu a siri ike ọ bụghị nanị na-eme ka ọ nwee ebe dị elu karị, kamakwa mgbe a na-ejikọta ya na mbadamba nkume yana ọgwụ na ihe ndị ọzọ na-emepụta ihe, a na-emepụta ọtụtụ pores na capillaries na mbadamba mbadamba, nke mere na mbadamba nkume nwere ike ịbawanye mmiri mmiri. ọnụego nnabata na mmịpụta mmiri na-abawanye ọzịza. Iji L-HPC dị ka ihe mgbakwunye nwere ike ime ka mbadamba nkume ngwa ngwa gbasasịa n'ime ntụ ntụ edo, ma mee ka mgbasa, mgbasa na bioavailability nke mbadamba nkume dịkwuo mma. Dịka ọmụmaatụ, iji L-HPC mee ihe nwere ike ime ka mbelata nke mbadamba nkume paracetamol, mbadamba aspirin, na mbadamba chlorpheniramine dị ngwa, ma melite ọnụego mgbasa. Mgbasa na mgbasa nke ọgwụ ndị na-adịghị edozi ahụ dị ka mbadamba ofloxacin nwere L-HPC dị ka ndị na-eme ka ọ dị mma karịa ndị nwere PVPP jikọtara ọnụ, CMC-Na na CMS-Na dị ka ndị na-agbasa. Iji L-HPC dị ka ihe na-eme ka ọkpụkpụ dị n'ime ya na-eme ka ọkpụkpụ dị na capsules na-aba uru na nkwụsị nke granules, na-eme ka mpaghara kọntaktị dị n'etiti ọgwụ ahụ na mgbasa ozi mgbasa ozi, na-akwalite mgbasa nke ọgwụ ahụ, na-eme ka bioavailability dịkwuo mma. Ngwa ngwa ngwa ngwa ngwa ngwa ngwa ngwa na-anọchi anya ngwa ngwa na-agbaji ngwa ngwa ngwa ngwa ngwa ngwa na ngwa ngwa ngwa ngwa ngwa ngwa na-agbaji ngwa ngwa, ngwa ngwa na-eme ngwa ngwa, nnukwu bioavailability, belata iwe iwe ọgwụ na esophagus na eriri afọ, ma dị mma iji were. ma nwee nnabata nke ọma. na uru ndị ọzọ, na-eburu ọnọdụ dị mkpa n'ọhịa nke ụlọ ahịa ọgwụ. L-HPC aghọwo otu n'ime ihe ndị kachasị mkpa maka ngwa ngwa na-ahapụ ngwa ngwa siri ike n'ihi ike hydrophilicity ya, hygroscopicity, expansibility, obere oge hysteresis maka ịmị mmiri, ngwa ngwa ngwa ngwa ngwa ngwa ngwa ngwa, na saturation mmiri na-amịpụta ngwa ngwa. Ọ bụ ihe mgbasa dị mma maka mbadamba ụrọ na-etisa. A na-eji L-HPC kwadoro mbadamba nkume ndị na-etisa paracetamol dị ka ndị na-agbasasị, na mbadamba nkume ndị ahụ gbasasịrị ngwa ngwa n'ime afọ 20. A na-eji L-HPC mee ihe dị ka ihe mgbasa maka mbadamba nkume, yana usoro ọgwụgwọ ya n'ozuzu bụ 2% ruo 10%, nke ka ukwuu 5%.
2. Dị ka ihe nkedo maka nkwadebe dị ka mbadamba nkume na granules
Ọdịdị siri ike nke L-HPC na-emekwa ka ọ nwee mmetụta dị ukwuu nke mosaic na ọgwụ na ihe dị iche iche, nke na-eme ka ogo nke ịdị n'otu na-abawanye, ma nwee ezigbo mkpakọ ịkpụzi arụmọrụ. Mgbe etinyere ya na mbadamba nkume, ọ na-egosi ike siri ike na gloss, si otú ahụ na-eme ka ọdịdị nke mbadamba nkume dịkwuo mma. Karịsịa maka mbadamba nkume ndị na-adịghị mfe ịmepụta, rụrụ arụ ma ọ bụ dị mfe ikpughe, ịgbakwunye L-HPC nwere ike imeziwanye mmetụta ahụ. Mbadamba ụrọ ciprofloxacin hydrochloride enweghị mkpakọ na-adịghị mma, ọ dị mfe kewaa na nnyapade, yana ọ dị mfe imepụta mgbe agbakwunyere L-HPC, ya na isi ike dabara adaba, ọdịdị mara mma, na ọnụego mgbasa na-emezu ụkpụrụ achọrọ. Mgbe agbakwunyere L-HPC n'ime mbadamba nkume a na-ekesa, ọdịdị ya, friability, ịdị n'otu na akụkụ ndị ọzọ na-akawanye mma ma na-emeziwanye ya. Mgbe L-HPC dochie starch dị na ndenye ọgwụ mbụ, a na-abawanye ike nke mbadamba azithromycin na-ekesa, emeziwanye friability ahụ, na-edozi nsogbu nke akụkụ ndị na-efu efu na akụkụ rere ure nke mbadamba nkume mbụ ahụ. A na-eji L-HPC mee ihe dị ka ihe nkedo maka mbadamba nkume, yana usoro ọgwụgwọ n'ozuzu bụ 5% ruo 20%; ebe H-HPC na-eji dị ka ihe nkedo maka mbadamba nkume, granules, wdg, na n'ozuzu onunu ogwu bụ 1% ka 5% nke nkwadebe.
3. Ngwa na mkpuchi ihe nkiri na nkwado ntọhapụ na-achịkwa ma na-achịkwa
Ka ọ dị ugbu a, ihe ndị na-agbaze mmiri na-ejikarị na mkpuchi ihe nkiri gụnyere hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, polyethylene glycol (PEG) na ihe ndị ọzọ. A na-ejikarị hydroxypropyl cellulose dị ka onye na-emepụta ihe nkiri na ihe mkpuchi ihe nkiri n'ihi ihe nkiri siri ike, na-agbanwe na nke na-egbuke egbuke. Ọ bụrụ na agwakọta hydroxypropyl cellulose na ihe mkpuchi mkpuchi okpomọkụ ndị ọzọ, enwere ike imeziwanye arụmọrụ nke mkpuchi ya.
N'iji ihe mgbakwunye kwesịrị ekwesị na usoro iji mee ka ọgwụ ahụ bụrụ mbadamba nkume matrix, mbadamba ihe na-ese n'elu mmiri, mbadamba ihe mkpuchi multi-layer, mbadamba nkume mkpuchi, mbadamba osmotic pump na mbadamba ndị ọzọ na-eji nwayọọ na nke a na-achịkwa, ihe ọ pụtara bụ: ịbawanye ogo nke absorption na ọgwụ na-edozi ahụ. ọgwụ n'ime ọbara. Ntinye uche, belata mmeghachi omume na-adịghị mma, belata ọnụ ọgụgụ ọgwụ, ma gbalịsie ike na-abawanye mmetụta ọgwụgwọ na obere dose, ma belata mmeghachi omume ọjọọ. Hydroxypropyl cellulose bụ otu n'ime ihe ndị na-enye nkwado dị otú ahụ. A na-achịkwa mgbasa na ntọhapụ nke mbadamba sodium diclofenac site na iji hydroxypropyl cellulose na ethyl cellulose dị ka ihe nkwonkwo na ọkpụkpụ. Mgbe nchịkwa ọnụ na kọntaktị na ihe ọṅụṅụ gastric, elu nke diclofenac sodium kwadoro mbadamba mbadamba ga-agbapụta n'ime gel. Site na mgbasa nke gel na mgbasa nke mkpụrụ ndụ ọgwụ na oghere gel, a na-enweta ebumnuche nke ịhapụ ngwa ngwa nke mkpụrụ ndụ ọgwụ. A na-eji hydroxypropyl cellulose mee ihe dị ka matrix na-achịkwa-mwepu nke mbadamba nkume, mgbe ọdịnaya nke blocker ethyl cellulose na-adịgide adịgide, ọdịnaya ya na mbadamba nkume na-ekpebi ntọhapụ nke ọgwụ ahụ ozugbo, yana ọgwụ sitere na mbadamba nkume nwere ọdịnaya dị elu. nke hydroxypropyl cellulose Mwepụta ji nwayọọ nwayọọ. A na-akwadebe pellets ndị a kpuchiri ekpuchi site na iji L-HPC na akụkụ ụfọdụ nke HPMC dị ka ihe ngwọta mkpuchi maka mkpuchi dị ka oyi akwa na-egbuke egbuke, yana dịka ihe mkpuchi na-achịkwa maka mkpuchi na ethyl cellulose aqueous dispersion. Mgbe edobere ndenye ọgwụ oyi akwa na usoro onunu ogwu, site n'ịchịkwa oke nke oyi akwa ntọhapụ a na-achịkwa, enwere ike ịhapụ pellet ndị mkpuchi n'oge dị iche iche a tụrụ anya ya. A na-agwakọta ọtụtụ ụdị pellet mkpuchi mkpuchi nwere uru ịdị arọ dị iche iche nke oyi akwa ntọhapụ a na-achịkwa ka Shuxiong kwadoro capsules. Na mgbasa mgbasa, pellets mkpuchi dị iche iche nwere ike ịhapụ ọgwụ n'usoro n'usoro n'oge dị iche iche, nke mere na ihe ndị nwere ihe dị iche iche nke anụ ahụ na nke kemịkal na-enweta ntọhapụ n'otu oge n'otu oge dị ka ntọhapụ na-adịgide adịgide.
Oge nzipu: Dec-28-2022