Site na mmepe nke ụlọ ọrụ na-emepụta ọgwụ na-aga n'ihu na ọganihu nke nkà na ụzụ ọgwụ, ọchịchọ maka ụdị usoro ọgwụgwọ ọgwụ na-arịwanye elu. N'ime ọtụtụ ụdị usoro onunu ogwu, capsules aghọwo ụdị ọgwụgwọ a na-ejikarị eme ihe na ụlọ ọrụ ọgwụ n'ihi ezi bioavailability ha na nnabata ndị ọrịa. N'ime afọ ndị na-adịbeghị anya, HPMC (hypromellose) capsules efu ejirila nwayọọ nwayọọ na-arụ ọrụ dị mkpa na mmepụta ọgwụ n'ihi uru dị ịrịba ama ha.
(1) Nlebanya bụ isi nke capsules efu HPMC
HPMC, ma ọ bụ hypromellose, bụ ngwakọta polymer sitere n'okike na-enwetakarị site na osisi pulp ma ọ bụ eriri owu site na usoro ọgwụgwọ kemịkal. Ọdịdị pụrụ iche nke HPMC na-enye ya ọmarịcha anụ ahụ na kemịkalụ, dị ka nghọta dị elu, ike igwe dị mma, solubility kwụsiri ike, na viscosity kwesịrị ekwesị. Ngwongwo ndị a na-eme HPMC n'ọtụtụ ebe, karịsịa na mpaghara ọgwụ.
(2) The isi uru nke HPMC efu capsules
1. ndakọrịta mmalite nke osisi na anaghị eri anụ
Akụrụngwa nke HPMC efu capsules bụ nke sitere na eriri osisi, nke na-eme ka ọ bụrụ ezigbo nhọrọ maka ndị anaghị eri anụ. N'adịghị ka capsules gelatin ọdịnala, HPMC capsules efu enweghị ihe anụmanụ, yabụ, ahịa ahịa ha na-eto ngwa ngwa na mpaghara nwere mmachi anaghị eri anụ, okpukperechi ma ọ bụ omenala. Uru a abụghị naanị kwekọrọ na nchegbu nke ndị na-azụ ahịa taa gbasara ahụike na nchekwa gburugburu ebe obibi, kamakwa na-enye nkwado siri ike maka ụlọ ọrụ ọgwụ iji gbasaa ahịa ụwa.
2. Ezi nkwụsi ike nke kemịkal
Capsules efu HPMC kwụsiri ike na akụrụngwa kemịkalụ yana ihe gburugburu ebe obibi dị ka okpomọkụ na iru mmiri anaghị emetụta ngwa ngwa. Ihe onwunwe a na-enye ya uru dị ukwuu n'oge nchekwa na njem. N'ụzọ dị iche, capsules gelatin na-enwekarị mmeghachi omume na-agafe agafe na oke okpomọkụ na oke iru mmiri, nke na-emetụta solubility na bioavailability nke ọgwụ. Capsules efu HPMC nwere ike idowe ihe ndị na-arụ ọrụ nke ọgwụ ahụ ma gbatịa ndụ ọgwụ ahụ.
3. Ezigbo solubility na bioavailability
HPMC efu capsules nwere ngwa ngwa mgbasa mgbasa na elu absorption ọnụego na ahụ mmadụ, nke na-enye ohere ka a na-ahapụ ọgwụ ngwa ngwa n'ime ahụ wee nweta ezigbo ọgwụgwọ mmetụta. Uru pH nke gburugburu ebe obibi adịghị emetụta solubility ya ma nwee ike ịnọgide na-enwe ọ̀tụ̀tụ̀ mgbasa ozi kwụsiri ike n'ime nnukwu pH. Ke adianade do, HPMC efu capsules nwere ike adhesion na eriri afọ tract, nke mmemmem obodo absorption nke ọgwụ na n'ihu mma bioavailability nke ọgwụ ọjọọ.
4. Kwado ngwa ngwa dị iche iche n'ụdị usoro onunu ogwu
Capsules efu HPMC nwere ike ọrụ dị mma ma nwee ike imeghari chọrọ ndochi ngwa ngwa nke ahịrị mmepụta akpaaka ma belata mfu n'oge usoro mmepụta. Na mgbakwunye, HPMC efu capsules nwere ike nrụgide na-eguzogide na ezigbo akara Njirimara, nke nwere ike n'ụzọ dị irè gbochie ọgwụ ọjọọ si na-mmiri ma ọ bụ oxidized. N'ihi na-anọpụ iche ọdịdị nke HPMC efu capsules, ha na-dakọtara na a dịgasị iche iche nke ọgwụ Efrata na adabara dị iche iche onunu ogwu ụdị, dị ka siri ike nkwadebe, mmiri mmiri preparations, ọkara siri ike nkwadebe, wdg.
5. Belata ihe ize ndụ nke mmeghachi omume nfụkasị ahụ
Ọzọ dị ịrịba ama uru nke HPMC efu capsules bụ ha hypoallergenicity. N'iji ya na capsules gelatin ọdịnala, capsules HPMC enweghị protein, yabụ ihe ize ndụ nke mmeghachi ahụ nfụkasị na-ebelata nke ukwuu. Nke a dị mkpa karịsịa maka ndị ọrịa nwere allergies na protein anụmanụ, na-eme ka ọgwụ ahụ dị nchebe iji mee ihe na ndị ọrịa ndị a.
(3) Ihe ịma aka na atụmanya nke HPMC efu capsules na mmepụta ọgwụ
Ọ bụ ezie na HPMC efu capsules nwere nnukwu uru n'ọtụtụ akụkụ, ngwa ha juru ebe niile na mmepụta ọgwụ ka na-eche nsogbu ụfọdụ ihu. Dịka ọmụmaatụ, ọnụ ahịa capsules efu HPMC dị elu ma e jiri ya tụnyere capsules gelatin ọdịnala nwere ike bụrụ ihe mgbochi n'ahịa ụfọdụ nwere ọnụ ahịa. Na mgbakwunye, ọdịnaya mmiri nke capsules efu HPMC dị obere, yana iji n'ụdị usoro ọgwụgwọ akọrọ nwere ike ịchọ nkwalite nhazi ọzọ.
Site na ọganihu nke nkà na ụzụ na mgbasawanye nke mmepụta ihe, a na-atụ anya na a ga-ebelata ọnụ ahịa mmepụta nke HPMC efu capsules. N'otu oge ahụ, mmụba nke ndị na-azụ ahịa maka ahụike na nchekwa gburugburu ebe obibi ga-akwalite ngwa nke capsules efu HPMC n'ahịa ụwa. Na mgbakwunye, njikarịcha usoro nke HPMC capsules efu na mmepe nke ihe ọhụrụ ga-abawanye asọmpi ya na ụlọ ọrụ ọgwụ.
HPMC efu capsules egosila sara mbara atụmanya na-emepụta ọgwụ n'ihi na ha osisi si malite, chemical kwụsie ike, ezi solubility na bioavailability, obosara ngwa adaptability na ala allergenicity. N'agbanyeghị na-eche ihu ụfọdụ ihe ịma aka, na ọganihu nke nkà na ụzụ na uto nke ahịa na-achọ, HPMC efu capsules na-atụ anya na ọ ga-anọ n'ọnọdụ dị mkpa na-eme n'ọdịnihu na-emepụta ọgwụ ụlọ ọrụ, na-enye ụlọ ọrụ ọgwụ ndị ọzọ nhọrọ na ohere.
Oge nzipu: Sep-03-2024