Hydroxypropyl methylcellulose (HPMC) yog ib qho khoom siv ntau yam siv dav hauv kev lag luam tshuaj, zaub mov thiab tshuaj pleev ib ce. Qhov no cellulose derivative yog muab los ntawm tej yam ntuj tso cellulose thiab hloov mus cuag tej yam khoom, ua rau nws ib tug indispensable muaj nyob rau hauv ntau yam formulations.
1. Taw qhia rau Hydroxypropyl Methylcellulose (HPMC)
1.1. Cov qauv tshuaj thiab cov khoom
Hydroxypropylmethylcellulose yog ib tug semi-synthetic polymer muab los ntawm cellulose, lub ntsiab structural tivthaiv ntawm cog cell phab ntsa. Cov qauv tshuaj lom neeg ntawm HPMC muaj cov kab mob cellulose txuas nrog hydroxypropyl thiab methyl pawg. Qhov kev hloov pauv ntawm cov pab pawg no cuam tshuam rau cov solubility, viscosity, thiab lwm yam khoom ntawm lub cev ntawm cov polymer.
HPMC feem ntau yog dawb los yog dawb dawb nyob rau hauv tsos, tsw thiab tasteless. Nws yog soluble hauv dej thiab cov ntaub ntawv ntshiab, viscous daws, ua rau nws muaj txiaj ntsig hauv ntau yam kev siv.
1.2. Cov txheej txheem tsim khoom
Kev tsim tawm ntawm hydroxypropyl methylcellulose koom nrog etherification ntawm cellulose siv propylene oxide thiab methyl chloride. Cov txheej txheem no hloov cov pawg hydroxyl hauv cov cellulose chains, ua rau tsim cov hydroxypropyl thiab methyl ether pawg. Kev tswj cov qib ntawm kev hloov pauv thaum lub sijhawm tsim khoom ua rau kev hloov kho ntawm HPMC cov khoom.
2. Lub cev thiab tshuaj muaj zog
2.1. Solubility thiab viscosity
Ib qho ntawm cov khoom tseem ceeb ntawm HPMC yog nws cov solubility hauv dej. Tus nqi ntawm dissolution nyob ntawm qhov degree ntawm kev hloov thiab molecular hnyav. Tus cwj pwm solubility no ua rau nws tsim nyog rau ntau hom kev tsim kom muaj kev tswj xyuas los yog tsim cov gel.
Lub viscosity ntawm HPMC cov kev daws teeb meem kuj yog kho tau, xws li qib qis mus rau qib siab viscosity. Cov cuab yeej no yog qhov tseem ceeb rau kev kho cov khoom rheological ntawm formulations xws li cream, gels thiab ophthalmic daws.
2.2. Kev ua yeeb yaj kiab
HPMC paub txog nws lub peev xwm tsim cov yeeb yaj kiab, ua rau nws yog cov khoom siv zoo tshaj plaws rau txheej cov ntsiav tshuaj thiab granules. Cov yeeb yaj kiab uas tau tshwm sim yog pob tshab thiab hloov pauv, muab cov txheej txheem tiv thaiv rau cov khoom siv tshuaj nquag (API) thiab txhawb kev tswj hwm kev tso tawm.
2.3. Thermal stability
Hydroxypropyl methylcellulose muaj thermal stability zoo, tso cai rau nws tiv taus ntau yam kub uas tau ntsib thaum lub sijhawm tsim khoom. Cov cuab yeej no ua kom yooj yim rau kev tsim cov ntawv ntim khoom, suav nrog cov ntsiav tshuaj thiab tshuaj ntsiav.
3. Daim ntawv thov ntawm hydroxypropyl methylcellulose
3.1. Kev lag luam kws tshuaj
HPMC yog dav siv nyob rau hauv kws tshuaj raws li ib tug excipient nyob rau hauv cov ntsiav tshuaj formulations thiab muaj ntau yam kev siv. Nws ua raws li ib tug binder, tswj lub disintegration thiab tso tawm ntawm active cov khoom xyaw. Tsis tas li ntawd, nws cov khoom ua yeeb yaj kiab ua rau nws tsim nyog rau cov ntsiav tshuaj txheej los muab cov txheej txheem tiv thaiv.
Hauv kev tsim cov kua hauv qhov ncauj, HPMC tuaj yeem siv los ua tus neeg sawv cev ncua, thickener, lossis kho viscosity. Nws siv nyob rau hauv cov tshuaj ophthalmic yog ib qho tseem ceeb rau nws cov mucoadhesive zog, uas txhim kho ocular bioavailability.
3.2. Kev lag luam zaub mov
Kev lag luam khoom noj khoom haus siv HPMC ua cov thickener thiab gelling tus neeg sawv cev hauv ntau yam khoom. Nws lub peev xwm los tsim cov gels ntshiab thiab tswj cov viscosity ua rau nws muaj txiaj ntsig hauv cov ntawv thov xws li kua ntses, hnav khaub ncaws thiab khoom noj khoom haus. HPMC feem ntau nyiam tshaj li cov tshuaj thickeners vim hais tias ntawm nws cov versatility thiab tsis muaj kev cuam tshuam rau lub sensory khoom ntawm cov khoom noj.
3.3. Tshuaj pleev ib ce thiab khoom tu tus kheej
Hauv cov qauv tshuaj pleev ib ce, HPMC yog siv rau nws cov thickening, stabilizing thiab zaj duab xis-tsim cov khoom. Nws feem ntau pom muaj nyob rau hauv cream, tshuaj pleev ib ce, thiab cov khoom tu plaub hau. Lub peev xwm ntawm polymer los txhim kho kev ntxhib los mos thiab kev ruaj ntseg ntawm cov formulations pab txhawb rau nws txoj kev siv dav hauv kev lag luam tshuaj pleev ib ce.
3.4. Kev tsim kho kev lag luam
HPMC yog siv nyob rau hauv kev tsim kho kev lag luam raws li ib tug retaining neeg sawv cev rau cement-based mortars thiab gypsum-raws li cov ntaub ntawv. Nws txoj haujlwm yog txhawm rau txhim kho kev ua tau zoo, tiv thaiv kev tawg, thiab txhim kho adhesion.
4. Kev txiav txim siab thiab kev nyab xeeb profile
4.1. Kev tswj hwm txoj cai
Hydroxypropyl methylcellulose feem ntau lees paub tias muaj kev nyab xeeb (GRAS) los ntawm cov koom haum tswj hwm xws li US Food and Drug Administration (FDA) thiab European Food Safety Authority (EFSA). Nws ua tau raws ntau yam qauv tshuaj pharmacopoeial thiab tau teev nyob rau hauv lawv cov monographs.
4.2. Kev ruaj ntseg txheej txheem cej luam
Raws li cov khoom siv dav siv, HPMC muaj qhov profile zoo. Txawm li cas los xij, cov tib neeg uas paub txog kev ua xua rau cellulose derivatives yuav tsum tau ceev faj. Qhov concentration ntawm HPMC nyob rau hauv cov mis yog nruj me ntsis tswj kom muaj kev ruaj ntseg, uas yog ib qho tseem ceeb rau tib neeg. Cov neeg tsim khoom ua raws li cov txheej txheem tsim.
5. Kev xaus thiab kev cia siab yav tom ntej
Hydroxypropyl methylcellulose tau tshwm sim los ua ntau yam khoom siv nrog ntau yam kev siv hauv kev lag luam tshuaj, zaub mov, tshuaj pleev ib ce thiab kev tsim kho. Nws qhov tshwj xeeb ua ke ntawm solubility, viscosity tswj thiab zaj duab xis-tsim cov khoom ua rau nws muaj txiaj ntsig muaj txiaj ntsig hauv ntau cov qauv.
Kev tshawb fawb txuas ntxiv thiab kev txhim kho hauv kev tshawb fawb ntawm polymer yuav ua rau muaj kev nce qib ntxiv hauv HPMC kev ua tau zoo kom tau raws li cov kev xav tau tshwj xeeb hauv kev lag luam. Raws li kev thov rau kev tswj-tso formulations thiab cov khoom tsim kho tshiab txuas ntxiv zuj zus tuaj, hydroxypropyl methylcellulose zoo li yuav tuav nws lub luag haujlwm tseem ceeb ua ntau yam khoom noj.
Post lub sij hawm: Jan-15-2024