Hydroxypropylcellulose (HPC) yog ib qho khoom siv tshuaj uas nquag siv hauv cov tshuaj raug tshem tawm. Suspensions yog cov txheej txheem heterogeneous uas muaj cov khoom sib cais hauv lub tsheb ua kua. Cov formulations yog dav siv nyob rau hauv pharmaceuticals xa cov tshuaj uas tsis zoo soluble los yog unstable nyob rau hauv kev daws. HPC ua haujlwm rau ntau lub luag haujlwm tseem ceeb hauv cov txheej txheem tshem tawm, ua rau lawv ruaj khov, viscosity, thiab kev ua haujlwm tag nrho.
1. Taw qhia rau Hydroxypropylcellulose (HPC):
Hydroxypropylcellulose yog ib qho cellulose derivative tau los ntawm kev hloov tshuaj lom neeg ntawm cellulose los ntawm kev qhia cov pab pawg hydroxypropyl mus rau hauv cov pob txha cellulose. Nws yog dav siv nyob rau hauv pharmaceuticals raws li ib tug excipient vim nws cov khoom zoo xws li solubility nyob rau hauv dej thiab organic solvents, biodegradability, film-forming peev xwm, thiab compatibility nrog rau lwm yam excipients thiab active tshuaj cov khoom xyaw (APIs).
2. Lub luag hauj lwm ntawm HPC hauv Suspension Formulations:
Hauv kev ncua kev tsim tawm, HPC ua haujlwm ntau yam:
ib. Suspension Stabilization:
Ib qho ntawm cov haujlwm tseem ceeb ntawm HPC hauv kev tshem tawm yog kom ruaj khov ntawm cov khoom tawg. Nws ua tiav qhov no los ntawm kev tsim cov txheej txheem tiv thaiv ib puag ncig cov khoom, tiv thaiv lawv los ntawm kev sib sau los yog teeb tsa. Qhov kev ruaj khov no yog qhov tseem ceeb rau kev tswj xyuas qhov sib xws thiab qhov sib xws ntawm kev ncua thoob plaws nws lub neej txee.
b. Kev hloov kho viscosity:
HPC tuaj yeem cuam tshuam qhov viscosity ntawm kev ncua. Los ntawm kev kho qhov concentration ntawm HPC nyob rau hauv lub formulation, lub viscosity tuaj yeem raug kho kom ua tiav cov khoom rheological xav tau. Tsim nyog viscosity xyuas kom txaus ncua kev kawm ntawv ntawm cov khoom thiab yooj yim ntawm pouring thiab dosing.
c. Txhim kho Pourability thiab Redispersibility:
HPC txhim kho cov dej ntws tawm ntawm kev ncua, ua rau lawv yooj yim rau nchuav thiab ua haujlwm. Tsis tas li ntawd, nws pab nyob rau hauv redispersion ntawm hais thaum lub ncua kev kawm ntawv yog shaken los yog agitated, kom ntseeg tau tias uniformity thiab sib xws ntawm kev tswj.
d. Compatibility thiab Stability:
HPC yog sib xws nrog ntau yam ntawm cov khoom xyaw tshuaj thiab excipients. Nws inert xwm thiab tsis muaj reactivity ua rau nws haum rau siv nyob rau hauv ntau yam formulations. Tsis tas li ntawd, HPC pab txhawb kev ruaj ntseg ntawm kev ncua los ntawm kev tiv thaiv theem kev sib cais, sedimentation, los yog siv lead ua loj hlob.
3. Mechanism of Action of HPC in Suspensions:
Lub tshuab uas HPC ua haujlwm hauv kev ncua kev cuam tshuam nrog nws cov kev cuam tshuam nrog ob qho tib si khoom thiab lub tsheb ua kua. Thaum dispersion nyob rau hauv cov kua theem, HPC molecules tsim ib tug peb-dimensional network ntawm hydrogen bonding thiab polymer entanglement. Lub network no encapsulates cov khoom hais, tiv thaiv lawv agglomeration thiab nyob. Lub viscosity ntawm kev ncua yog cuam tshuam los ntawm qhov concentration thiab molecular hnyav ntawm HPC, nrog ntau dua concentrations thiab molecular hnyav uas ua rau muaj zog viscosity.
4. Kev siv ntawm HPC hauv Pharmaceutical Suspensions:
Hydroxypropylcellulose pom kev siv dav hauv ntau yam tshuaj raug tshem tawm, suav nrog:
ib. Qhov ncauj Suspensions:
HPC feem ntau yog siv rau hauv qhov ncauj tshem tawm los tsim cov tshuaj tsis zoo rau kev tswj qhov ncauj. Nws txhim kho cov solubility thiab bioavailability ntawm cov khoom xyaw nquag thaum kom ntseeg tau tias muaj kev sib cais thiab qhov tseeb npaum li cas.
b. Topical Suspensions:
Hauv kev tshem tawm cov tshuaj pleev ib ce, HPC ua haujlwm ua tus neeg sawv cev ncua rau cov tshuaj insoluble lossis tsis zoo soluble npaj rau dermal lossis transdermal xa. Nws imparts viscosity rau formulation, txhim kho nws cov kis tau thiab adhesion rau ntawm daim tawv nqaij.
c. Ophthalmic Suspensions:
Rau ophthalmic suspensions, HPC yog siv los ua kom ruaj khov ntawm cov khoom tawg thiab tswj lawv cov kev faib tawm hauv qhov muag poob. Nws biocompatibility thiab cov khoom tsis ua rau khaus ua rau nws haum rau kev siv ophthalmic.
d. Parenteral Suspensions:
Nyob rau hauv parenteral suspensions, qhov twg yuav tsum tau txhaj tshuaj formulations, HPC yuav siv tau raws li ib tug stabilizing neeg sawv cev. Txawm li cas los xij, nws txoj kev siv hauv parenteral formulations raug txwv vim kev xav txog kev nyab xeeb thiab kev sib raug zoo nrog txoj kev txhaj tshuaj.
5. Xaus:
Hydroxypropylcellulose (HPC) yog ib qho khoom siv tshuaj ntau yam uas siv dav hauv cov tshuaj raug tshem tawm. Nws muaj peev xwm ua kom ruaj khov cov khoom sib cais, hloov kho viscosity, txhim kho cov dej ntws, thiab txhim kho kev sib raug zoo ua rau nws tseem ceeb hauv kev tsim cov tshuaj ncua rau qhov ncauj, tshuaj pleev ib ce, ophthalmic, thiab lwm yam kev tswj hwm. Kev nkag siab txog lub luag haujlwm thiab cov txheej txheem ntawm kev ua ntawm HPC hauv kev ncua yog qhov tseem ceeb rau kev txhim kho cov qauv tshuaj zoo thiab ruaj khov. Raws li kev tshawb fawb thiab thev naus laus zis txuas ntxiv mus, kev siv HPC hauv cov tshuaj raug tshem tawm zoo li yuav hloov zuj zus, muab cov hauv kev ntxiv rau kev tsim kho tshiab thiab kev txhim kho hauv kev xa tshuaj.
Post lub sij hawm: Mar-27-2024