Hydroxypropyl methylcellulose (HPMC) yog cov khoom siv polymer feem ntau siv hauv kev npaj tshuaj.Vim nws lub cev zoo heev thiab tshuaj lom neeg, nws ua lub luag haujlwm tseem ceeb hauv kev tsim cov ntsiav tshuaj.HPMC tuaj yeem siv los ua cov yeeb yaj kiab yav dhau los, tswj kev tso tawm tus neeg sawv cev, nplaum, thickener, thiab lwm yam, muab cov ntsiav tshuaj zoo qauv thiab ua haujlwm.
1. Zaj movie qub
Lub luag hauj lwm ntawm HPMC raws li ib tug zaj duab xis yav dhau los yog feem ntau xav txog nyob rau hauv lub nto txheej ntawm cov tshuaj tso tawm tshuaj.Cov ntsiav tshuaj txheej yog nqa tawm rau lub hom phiaj ntawm kev tswj cov kev tso tawm ntawm cov tshuaj, tiv thaiv cov tshuaj los ntawm ib puag ncig influences, thiab txhim kho cov tsos ntawm cov tshuaj.Hauv kev tswj hwm kev npaj tawm, cov yeeb yaj kiab tsim los ntawm HPMC tuaj yeem kho tus nqi tso tawm ntawm cov tshuaj, xyuas kom meej tias cov tshuaj raug tso tawm hauv qee qhov ntawm lub plab zom mov, thiab ua tiav cov txiaj ntsig zoo tshaj plaws.
Mechanism of action: Cov yeeb yaj kiab tsim los ntawm HPMC zaj duab xis yav dhau los tuaj yeem ua tiav kev tswj hwm kev tso tawm tshuaj los ntawm kev tswj hwm kev nkag mus ntawm cov kuab tshuaj thiab cov tshuaj yaj yeeb.Lub thickness thiab muaj pes tsawg leeg ntawm cov yeeb yaj kiab tuaj yeem kho tus nqi tawg kom tau raws li qhov yuav tsum tau tso tawm ntawm cov tshuaj sib txawv.
Kev cuam tshuam: Cov ntsiav tshuaj siv HPMC los ua cov yeeb yaj kiab ua yeeb yaj kiab tuaj yeem yaj maj mam hauv plab, zam kev tso tshuaj sai sai, txhim kho kev siv tshuaj, thiab txo cov tshuaj lom rau hauv plab hnyuv.
2. Tswj kev tso tawm tus neeg sawv cev
HPMC feem ntau yog siv los ua cov khoom siv matrix hauv cov tshuaj tswj-tso tawm los tswj cov tshuaj tso tawm los ntawm kev tsim cov gel barrier.Lub luag haujlwm ntawm tus neeg saib xyuas kev tso tawm yog los xyuas kom meej tias cov tshuaj tso tawm sib npaug hauv lub sijhawm tshwj xeeb kom tswj tau qhov zoo ntawm cov tshuaj hauv lub cev, txo cov sijhawm siv tshuaj, thiab txhim kho kev ua raws li tus neeg mob.
Mechanism of action: Hauv cov xov xwm aqueous, HPMC tuaj yeem ua kom dej sai sai thiab tsim cov qauv colloidal network, uas tswj cov diffusion thiab tso tawm tus nqi ntawm cov tshuaj.Thaum cov ntsiav tshuaj los rau hauv kev sib cuag nrog dej, HPMC absorbs dej thiab swells los ua ib tug gel txheej, los ntawm uas cov tshuaj diffuses tawm ntawm lub cev, thiab qhov tso tawm tus nqi nyob ntawm seb lub thickness thiab ceev ntawm lub gel txheej.
Kev cuam tshuam: HPMC raws li tus neeg saib xyuas kev tso tawm tuaj yeem txhim kho tus nqi tso tawm cov tshuaj, txo qhov kev hloov pauv ntawm cov tshuaj ntshav siab, thiab muab cov txiaj ntsig kho kom ruaj khov, tshwj xeeb tshaj yog rau cov tshuaj kho mob ntev.
3. Cov ntaub ntawv
Hauv cov txheej txheem ntawm kev npaj cov ntsiav tshuaj, HPMC feem ntau yog siv los ua cov ntaub ntawv los txhim kho lub zog ntawm cov ntsiav tshuaj thiab ua kom muaj kev ncaj ncees ntawm cov ntsiav tshuaj thaum khaws cia, kev thauj mus los thiab kev tswj hwm.
Mechanism ntawm kev txiav txim: HPMC, raws li ib tug binder, muaj peev xwm tsim ib tug muaj zog daim ntawv cog lus ntawm hais, thiaj li hais tias cov hmoov los yog particles yog bonded thiab tsim rau hauv ib lub ntsiav tshuaj.Cov txheej txheem no feem ntau yog ua los ntawm cov txheej txheem ntub dej granulation, qhov twg HPMC yaj hauv cov kua dej los tsim cov kua dej khov, thiab tsim cov ntsiav tshuaj ruaj khov tom qab ziab.
Kev cuam tshuam: HPMC binders tuaj yeem txhim kho lub zog compressive thiab hardness ntawm cov ntsiav tshuaj, txo qhov kev pheej hmoo ntawm kev tawg lossis tawg, thiab yog li txhim kho cov ntsiav tshuaj zoo thiab ruaj khov.
4. Thickeners
HPMC tseem tuaj yeem siv los ua cov thickener hauv cov kua npaj los kho cov khoom rheological ntawm kev npaj thiab nce viscosity.
Mechanism ntawm kev ua: HPMC muaj viscosity siab hauv dej thiab tuaj yeem ua kom cov viscosity ntawm cov kua ua tau zoo, txhim kho qhov kev ncua thiab kev ruaj ntseg ntawm cov tshuaj, thiab tiv thaiv sedimentation.
Kev cuam tshuam: Ntxiv HPMC rau cov tshuaj ua kua tuaj yeem txhim kho qhov sib xws ntawm cov tshuaj, ua kom cov tshuaj sib npaug sib npaug thoob plaws qhov kev npaj, thiab xyuas kom meej npaum li cas txhua zaus.
Cov yam ntxwv ntawm Hydroxypropyl Methylcellulose
1. Lub cev thiab tshuaj muaj zog
HPMC yog nonionic cellulose ether nrog dej solubility zoo thiab thermal gelation.Nws yaj sai sai hauv dej txias los tsim cov kua dej ntshiab, thaum thaum sov, cov tshuaj hloov mus rau hauv gel.
2. Biocompatibility
HPMC muaj biocompatibility zoo thiab muaj kev nyab xeeb, thiab tsis nquag ua rau lub cev tiv thaiv kab mob lossis tshuaj lom, yog li nws tau siv dav hauv kev lag luam tshuaj thiab zaub mov.
3. Kev ruaj ntseg ib puag ncig
HPMC muaj kev ruaj ntseg zoo rau ib puag ncig yam xws li kub thiab pH tus nqi, thiab tsis ua rau degradation lossis denaturation, uas ua kom muaj kev ruaj ntseg ntawm kev npaj tshuaj thaum lub sij hawm cia.
Piv txwv ntawm HPMC Daim Ntawv Thov hauv Cov ntsiav tshuaj
1. Cov ntsiav tshuaj tso tawm
Piv txwv li, nyob rau hauv nifedipine sustained-tso ntsiav tshuaj siv los kho mob ntshav siab, HPMC yog siv los ua cov khoom siv matrix los tswj qhov kev tso tawm qeeb ntawm cov tshuaj, txo qhov zaus ntawm kev tswj hwm, thiab txhim kho kev ua raws li tus neeg mob.
2. Enteric-coated ntsiav tshuaj
Hauv cov ntsiav tshuaj enteric-coated ntawm proton twj tso kua mis inhibitors (xws li omeprazole), HPMC ua cov yeeb yaj kiab tsim los tiv thaiv cov tshuaj los ntawm kev puas tsuaj los ntawm gastric acid thiab xyuas kom meej tias cov tshuaj raug tso tawm hauv txoj hnyuv.
3. Qhov ncauj ceev-solving ntsiav tshuaj
Nyob rau hauv lub qhov ncauj ceev-dissolving ntsiav tshuaj rau kev kho mob ntawm allergic rhinitis, HPMC ua raws li ib tug thickener thiab nplaum los muab sai sai dissolution thiab uniform tso tawm, txhim kho saj thiab noj cov kev paub ntawm cov tshuaj.
Hydroxypropyl methylcellulose yog dav siv nyob rau hauv kev npaj ntawm ntau yam ntsiav tshuaj vim nws zoo heev film-forming, tswj kev tso tawm, adhesiveness thiab thickening zog.HPMC tuaj yeem tsis tsuas yog txhim kho lub cev thiab kev ruaj ntseg ntawm cov ntsiav tshuaj, tab sis kuj tseem txhim kho cov txiaj ntsig ntawm cov tshuaj los ntawm kev kho tus nqi tso tawm ntawm cov tshuaj.Nrog rau kev txhim kho ntawm cov cuab yeej siv tshuaj, daim ntawv thov ntawm HPMC yuav ua kom muaj ntau haiv neeg, muab ntau txoj hauv kev rau kev tsim kho tshiab ntawm kev npaj tshuaj.
Post lub sij hawm: Jun-27-2024