Hydroxypropyl methylcellulose (HPMC) yog siv dav hauv cov ntsiav tshuaj txheej. Raws li ib tug kws tshuaj excipient, nws muaj ntau yam functions thiab zoo.
Cov khoom siv ua yeeb yaj kiab: HPMC yog ib qho ntawm cov khoom siv ua yeeb yaj kiab hauv kev tsim cov yeeb yaj kiab. Nws muaj cov yeeb yaj kiab zoo tsim, tsim cov yeeb yaj kiab lub zog, pob tshab txheej txheej, thiab tsis yooj yim rau tawg. Nws yog qhov ruaj khov nyob rau hauv lub teeb, cua sov thiab qee cov av noo, thiab soluble hauv cov kuab tshuaj organic thiab dej. Nws muaj kev cuam tshuam me ntsis ntawm kev tawg thiab tawg ntawm cov ntsiav tshuaj. Yog li ntawd, nws yog ib tug dav siv gastric soluble txheej khoom nrog zoo zaj duab xis txheej nyhuv.
Tiv thaiv API: HPMC txheej tuaj yeem tiv thaiv cov khoom xyaw tshuaj nquag (API) los ntawm ib puag ncig xws li lub teeb, oxidation thiab ya raws, kom ntseeg tau tias cov tshuaj tuaj yeem ua haujlwm txuas ntxiv mus rau nws lub luag haujlwm txawm tias tom qab khaws cia rau lub sijhawm ntev.
Tswj cov tshuaj tso tawm: Los ntawm txheej zaj duab xis, cov chaw tsim tshuaj tuaj yeem tswj tau qhov chaw tso tawm, tus nqi thiab lub sijhawm API. Qhov no tseem ceeb heev rau qee cov tshuaj uas yuav tsum tau tso tawm nrog ncua sijhawm, lossis rau cov tshuaj uas yuav tsum tau tso tawm qhov API tas li hauv lub sijhawm tshwj xeeb.
Txhim kho kev ua raws li tus neeg mob: Cov ntsiav tshuaj zaj duab xis-coated yog yooj yim dua, uas tuaj yeem txhim kho kev ua raws li tus neeg mob.
Txhim kho cov ntsiav tshuaj zoo li: Zaj duab xis txheej tuaj yeem muab lub ntsej muag du thiab cov xim ci, txhim khu kev paub txog cov khoom lag luam thiab cov neeg mob kev noj tshuaj.
Raws li ib tug binder thiab disintegrant: HPMC kuj siv tau raws li ib tug binder. Nws cov tshuaj viscosity tsawg HPMC tuaj yeem txo qhov kev sib cuag lub kaum sab xis ntawm cov tshuaj, uas yog qhov zoo rau kev ntub dej ntawm cov tshuaj. Kev nthuav dav coefficient tom qab nqus dej tuaj yeem ncav cuag ntau pua zaus, uas tuaj yeem txhim kho qhov kev sib cais thiab kev sib cais tawm ntawm cov tshuaj.
Txhim kho cov ntsiav tshuaj ruaj khov: HPMC muaj hygroscopicity tsawg, uas tuaj yeem siv los ua qhov zoo dua vim tias nws tuaj yeem txo cov teeb meem kev ruaj ntseg los ntawm kev nqus noo noo thaum khaws cov ntsiav tshuaj.
Raws li cov khoom siv pob txha-tso tawm: Hauv kev npaj tso tawm, HPMC tuaj yeem siv los ua cov khoom siv pob txha pob txha. Los ntawm kev kho cov viscosity thiab ntau npaum li cas ntawm HPMC, qhov tso tawm ntawm cov tshuaj tuaj yeem tswj tau kom ua tiav cov txiaj ntsig-tso tawm ntawm cov tshuaj.
Txhim kho solubility: HPMC ethanol tov los yog aqueous tov yog siv los ua ib tug wetting agent rau granulation, uas yog zoo nyob rau hauv kev txhim kho cov solubility ntawm cov ntsiav tshuaj.
Txhim kho cov txheej txheem zoo: Raws li cov khoom siv ua yeeb yaj kiab, HPMC muaj qhov zoo tshaj plaws ntawm lwm cov ntaub ntawv ua yeeb yaj kiab vim tias nws yog dej-soluble, tsis xav tau cov kuab tshuaj organic, thiab muaj kev nyab xeeb thiab yooj yim rau kev khiav lag luam. HPMC kuj muaj ntau yam viscosity specifications. Yog tias siv tau zoo, qhov zoo thiab cov tsos ntawm cov ntsiav tshuaj coated yog zoo dua li lwm cov ntaub ntawv.
HPMC tau siv dav hauv cov ntsiav tshuaj txheej, uas tuaj yeem tsis tsuas yog txhim kho cov khoom zoo thiab cov tsos ntawm cov ntsiav tshuaj, tab sis kuj tseem tiv thaiv cov khoom xyaw tshuaj, tswj cov tshuaj tso tawm, thiab txhim kho kev ua raws li tus neeg mob.
Post lub sij hawm: Oct-29-2024