Hydroxypropylmethylcellulose (HPMC) E15 yog ib qho tshuaj ntau yam thiab ntau yam khoom siv nrog ntau yam siv hauv tshuaj, tshuaj pleev ib ce thiab zaub mov formulations. Muab los ntawm ntuj cellulose, qhov no cellulose derivative yog nrov vim nws cov yam ntxwv tshwj xeeb, nrog rau nws lub peev xwm los hloov cov tshuaj viscosity, txhim kho cov tshuaj tso tawm profiles, thiab txhim kho formulation stability.
1.HPMC E15 kev taw qhia:
Hydroxypropyl methylcellulose (HPMC):
HPMC yog ib tug semi-synthetic polymer muab los ntawm cellulose, ib tug natural polymer pom nyob rau hauv cov nroj tsuag cell phab ntsa. Nws yog tsim los ntawm kev kho cellulose nrog alkali thiab tom qab ntawd propylene oxide, uas ua rau cov tebchaw nrog hydroxypropyl thiab methoxy substituents. Qhov kev hloov kho no muab HPMC cov khoom tshwj xeeb, ua rau nws haum rau ntau yam kev siv.
2. Hydroxypropyl methylcellulose E15:
HPMC E15 tshwj xeeb yog hais txog qhov nruab nrab mus rau siab viscosity HPMC qib. Tus "E" hauv nws lub npe qhia tias nws ua raws li cov lus qhia tshwj xeeb tau teev tseg hauv European Pharmacopoeia. Cov qib tshwj xeeb no feem ntau siv rau hauv cov tshuaj formulations kom ua tiav cov yam ntxwv ua tau zoo.
3. Pharmaceutical applications:
A. Binders nyob rau hauv cov ntsiav tshuaj formulations:
HPMC E15 feem ntau yog siv los ua cov ntawv khi hauv cov ntsiav tshuaj. Nws cov khoom sib txuas ua ke pab khi cov khoom siv tshuaj nquag (API) thiab cov khoom ntxiv ua ke, ua kom cov ntsiav tshuaj cohesive thiab ruaj khov.
B. Matrix tsim cov neeg sawv cev hauv kev tswj kev tso tawm:
HPMC E15 tsim cov gel zoo li matrix thaum nyob rau hauv kev sib cuag nrog dej, ua rau nws tsim nyog rau kev tswj los yog sustained tso formulations. Qhov no ua kom muaj kev ruaj ntseg, tswj kev tso tawm ntawm cov tshuaj nyob rau lub sijhawm ntev, yog li txhim kho kev ua raws li tus neeg mob.
C. Zaj duab xis txheej tus neeg sawv cev:
HPMC E15 yog siv los ua ib zaj duab xis yav dhau los rau cov ntsiav tshuaj thiab ntsiav tshuaj txheej. Cov yeeb yaj kiab uas tshwm sim tiv thaiv cov tshuaj los ntawm ib puag ncig yam, txhim kho qhov tsos thiab yooj yim rau nqos.
D. Suspension agent:
Hauv cov kua hauv qhov ncauj formulations, HPMC E15 ua raws li tus neeg sawv cev ncua, tiv thaiv particle nyob rau hauv thiab ua kom muaj kev sib faib ntawm cov tshuaj thoob plaws hauv cov kua.
E. Thickener:
Nws cov viscosity-hloov cov khoom ua rau HPMC E15 muaj txiaj ntsig zoo li cov thickener hauv cov kua thiab cov khoom siv ib nrab xws li gels thiab cream, pab txhim kho lawv kev ruaj ntseg thiab yooj yim ntawm kev siv.
F. Disintegrant:
Hauv qee cov qauv, HPMC E15 tuaj yeem ua cov tshuaj tsis sib xws, txhawb nqa cov ntsiav tshuaj kom nrawm nrawm rau hauv cov khoom me me thaum sib cuag nrog dej, txhawb kev tso tshuaj thiab kev nqus.
G. Emulsion stabilizer:
Nyob rau hauv cov tshuaj pleev ib ce xws li cream thiab tshuaj pleev ib ce, HPMC E15 ua raws li ib tug stabilizer nyob rau hauv emulsions, tiv thaiv theem sib cais thiab ua rau tag nrho cov stability ntawm cov khoom.
H. Sustained tso tawm pellets:
HPMC E15 kuj tseem siv los tsim cov pellets txuas ntxiv uas muab cov tshuaj tswj cov tshuaj tso tawm thaum siv qhov ncauj.
4. Lwm yam kev siv:
A. Cosmetic formula:
Hauv cov tshuaj pleev ib ce, HPMC E15 yog siv ntau yam khoom xws li tshuaj pleev, tshuaj pleev thiab tshuaj zawv plaub hau los pab txhim kho kev ntxhib los mos, ruaj khov thiab kev ua tau zoo ntawm cov qauv.
B. Khoom noj khoom haus kev lag luam:
HPMC E15 qee zaum siv hauv kev lag luam khoom noj khoom haus ua cov thickener, stabilizer lossis emulsifier hauv cov khoom xws li kua ntses, hnav khaub ncaws thiab khoom ci.
C. Kev tsim kho kev lag luam:
Hauv kev tsim kho kev lag luam, HPMC E15 yog siv los ua ib qho ntxiv hauv cov khoom siv cement los txhim kho kev ua haujlwm, adhesion thiab dej tuav.
HPMC E15 yog ib qho khoom siv ntau yam thiab tseem ceeb tsis tau nrog ntau yam kev siv, tshwj xeeb tshaj yog nyob rau hauv kev lag luam tshuaj. Nws lub luag hauj lwm raws li ib tug binder, matrix yav dhau los, zaj duab xis txheej tus neeg saib xyuas, thiab ntau lwm yam functions ua rau nws ib tug tseem ceeb muaj nyob rau hauv lub qhov ncauj ntau npaum formulations. Ntxiv nrog rau kev siv tshuaj, nws siv txuas ntxiv mus rau cov tshuaj pleev ib ce, khoom noj khoom haus thiab kev tsim kho kev lag luam, ua kom pom nws qhov kev hloov pauv thiab qhov tseem ceeb hauv kev siv sib txawv. Raws li kev tshawb fawb thiab kev loj hlob nyob rau hauv cov cheeb tsam no txuas ntxiv mus, HPMC E15 zoo li yuav nyob twj ywm tseem ceeb hauv kev lag luam nrhiav kev txhim kho kev xa tshuaj, kev tsim qauv ruaj khov thiab txhim kho cov khoom lag luam.
Post lub sij hawm: Feb-06-2024