HPMC mechanism ntawm kev txiav txim yog dab tsi?

HPMC, los yog hydroxypropyl methylcellulose, yog ib qho hluavtaws, dej-soluble polymer muab los ntawm cellulose. Nws yog siv rau ntau yam kev siv, suav nrog zaub mov, tshuaj, tshuaj pleev ib ce, thiab cov khoom lag luam. HPMC yog non-ionic, viscosity-txhim kho cov polymer uas tuaj yeem siv los ua kom tuab, ruaj khov, thiab tshem tawm ntau yam khoom xyaw.

Lub mechanism ntawm kev txiav txim ntawm HPMC yog raws li nws lub peev xwm los tsim hydrogen bonds nrog dej molecules, tsim ib tug network ntawm intermolecular rog. Qhov kev sib txuas ntawm hydrogen bonds no tsim cov qauv peb-dimensional uas tuaj yeem ntes thiab tuav cov dej molecules. Cov matrix no yog lub luag haujlwm rau viscosity-txhim kho cov khoom ntawm HPMC, nrog rau nws lub peev xwm los ncua thiab tswj cov khoom xyaw.

HPMC kuj tseem muaj kev sib raug zoo rau lipids, uas tso cai rau nws los tsim kev tiv thaiv ib puag ncig cov khoom xyaw roj. Qhov kev thaiv no pab tiv thaiv cov khoom siv roj los ntawm kev sib cais los ntawm cov theem aqueous, yog li ua kom muaj kev ruaj ntseg ntawm cov formulation. Tsis tas li ntawd, kev tiv thaiv kev tiv thaiv tsim los ntawm HPMC yuav pab txo qis tus nqi ntawm evaporation ntawm cov khoom xyaw roj, uas tuaj yeem pab ua kom lub neej ntev ntawm cov txheej txheem.

Thaum kawg, HPMC tseem tuaj yeem ua raws li surfactant, uas yuav pab txo qis qhov nro ntawm cov dej daws teeb meem. Qhov no tuaj yeem pab txhim kho cov ntub dej thiab dispersing ntawm cov khoom xyaw, uas tuaj yeem txhim kho kev ruaj ntseg thiab kev ua tau zoo ntawm cov formulation.

Hauv cov ntsiab lus, cov txheej txheem ntawm kev ua ntawm HPMC yog raws li nws lub peev xwm los tsim hydrogen bonds nrog dej molecules, tsim kom muaj kev sib txuas ntawm cov rog sib txuas uas tuaj yeem ntes thiab tuav cov dej molecules. Lub network ntawm hydrogen daim ntawv cog lus no yog lub luag haujlwm rau viscosity-txhim kho cov khoom ntawm HPMC, nrog rau nws lub peev xwm los ncua thiab tswj cov khoom xyaw. Tsis tas li ntawd, HPMC muaj kev sib raug zoo rau cov lipids, uas tso cai rau nws los tsim kev tiv thaiv ib puag ncig cov khoom xyaw roj. Thaum kawg, HPMC tseem tuaj yeem ua raws li surfactant, uas yuav pab txo qis qhov nro ntawm cov dej daws teeb meem. Tag nrho cov khoom no ua rau HPMC muaj txiaj ntsig zoo thiab muaj ntau yam khoom siv rau ntau yam kev siv.