Methyl cellulose (MC) thiab hydroxypropyl methyl cellulose (HPMC) yog ob lub cellulose derivatives dav siv hauv kev lag luam, kev tsim kho, tshuaj, khoom noj thiab lwm yam. Txawm hais tias lawv zoo sib xws hauv cov qauv, lawv muaj cov khoom sib txawv thiab muaj qhov sib txawv tseem ceeb hauv kev siv thiab cov txheej txheem ntau lawm.
1. Qhov sib txawv ntawm cov qauv tshuaj
Methylcellulose (MC) thiab hydroxypropylmethylcellulose (HPMC) yog ob qho tib si muab los ntawm ntuj cellulose thiab yog cov tshuaj hloov kho cellulose ether compounds. Tab sis lawv qhov sib txawv tsuas yog nyob rau hauv hom thiab tus naj npawb ntawm cov pab pawg hloov pauv.
Methyl Cellulose (MC)
MC yog tsim los ntawm kev hloov cov hydroxyl pawg ntawm cellulose nrog methyl pawg (ie -OCH₃). Cov qauv tshuaj ntawm MC feem ntau muaj cov methyl substituent pawg ntawm cov saw hlau tseem ceeb hauv cellulose, thiab nws cov nqi hloov pauv cuam tshuam rau nws cov solubility thiab cov khoom. MC feem ntau yog soluble hauv dej txias tab sis tsis nyob hauv dej kub.
Hydroxypropyl methylcellulose (HPMC)
HPMC tau hloov kho ntxiv raws li methylcellulose, los ntawm kev hloov ib feem ntawm pawg hydroxyl nrog methyl (-CH₃) thiab hydroxypropyl (-CH₂CH(OH)CH₃). Piv nrog rau MC, cov qauv molecular ntawm HPMC yog qhov nyuaj dua, nws cov hydrophilicity thiab hydrophobicity zoo sib npaug, thiab nws tuaj yeem soluble hauv dej txias thiab kub.
2. Qhov sib txawv ntawm lub cev thiab tshuaj lom neeg cov khoom solubility
MC: Methylcellulose feem ntau muaj solubility zoo hauv dej txias, tab sis yuav tsim ib lub gel thaum kub nce. Nyob rau hauv dej kub, MC yuav insoluble, ua ib tug thermal gel.
HPMC: Hydroxypropyl methylcellulose tuaj yeem yaj zoo ib yam hauv cov dej txias thiab kub, muaj qhov sib txawv ntawm qhov kub thiab txias, thiab nws cov solubility ruaj khov dua MC.
Thermal gelability
MC: MC muaj zog thermal gelling zog. Thaum kub nce mus rau ib theem, nws yuav tsim ib gel thiab poob nws solubility. Cov yam ntxwv no ua rau nws muaj kev siv tshwj xeeb hauv kev tsim kho thiab kev lag luam tshuaj.
HPMC: HPMC kuj muaj qee yam thermal gelling zog, tab sis nws cov gel tsim kub siab dua thiab cov gel tsim ceev qeeb dua. Piv nrog rau MC, HPMC cov khoom siv thermal gel muaj peev xwm tswj tau ntau dua thiab yog li muaj txiaj ntsig zoo dua hauv cov ntawv thov uas xav tau qhov kub thiab txias dua.
Nto kev ua si
MC: MC muaj kev ua haujlwm qis. Txawm hais tias nws tuaj yeem siv los ua qee yam emulsifier lossis thickener hauv qee daim ntawv thov, cov nyhuv tsis tseem ceeb li HPMC.
HPMC: HPMC muaj qhov muaj zog ntawm qhov chaw ua haujlwm, tshwj xeeb tshaj yog cov kev taw qhia ntawm hydroxypropyl pawg, uas ua rau nws yooj yim rau emulsify, ncua thiab thicken hauv cov tshuaj. Yog li ntawd, nws yog dav siv raws li ib tug additive nyob rau hauv coatings thiab tsev cov ntaub ntawv.
Salt kam rau ua thiab pH stability
MC: Methylcellulose muaj cov ntsev tsis zoo thiab nws yooj yim rau nag lossis daus hauv qhov chaw muaj ntsev. Nws muaj kev ruaj ntseg tsis zoo hauv cov kua qaub thiab alkali ib puag ncig thiab yooj yim cuam tshuam los ntawm tus nqi pH.
HPMC: Vim muaj cov khoom siv hydroxypropyl, HPMC cov ntsev kam rau ua tau zoo dua li MC, thiab nws tuaj yeem tswj tau zoo solubility thiab stability nyob rau hauv ib tug dav pH ntau yam, yog li nws yog haum rau ntau yam tshuaj ib puag ncig.
3. Qhov sib txawv ntawm cov txheej txheem ntau lawm
Production ntawm MC
Methylcellulose yog tsim los ntawm cov tshuaj tiv thaiv methylation ntawm cellulose, feem ntau yog siv methyl chloride los teb nrog alkaline cellulose los hloov cov hydroxyl pawg hauv cellulose molecules. Cov txheej txheem no yuav tsum muaj kev tswj hwm ntawm cov tshuaj tiv thaiv kom ntseeg tau qhov tsim nyog ntawm kev hloov pauv, uas cuam tshuam rau kev solubility thiab lwm yam khoom siv physicochemical ntawm cov khoom kawg.
Kev tsim tawm ntawm HPMC
Kev tsim tawm ntawm HPMC yog ua raws li methylation thiab ntxiv cov tshuaj tiv thaiv hydroxypropylation. Ntawd yog, tom qab cov tshuaj tiv thaiv methylation ntawm methyl chloride, propylene oxide reacts nrog cellulose los tsim ib hydroxypropyl hloov. Kev taw qhia ntawm pawg hydroxypropyl txhim kho cov dej solubility thiab hydration peev xwm ntawm HPMC, uas kuj ua rau nws cov txheej txheem ntau lawm complex thiab me ntsis nqi dua MC.
4. Qhov txawv ntawm daim ntawv thov teb
Cov ntaub ntawv hauv tsev
MC: MC feem ntau siv hauv cov khoom siv hauv tsev, tshwj xeeb tshaj yog cov thickener, dej tuav tus neeg sawv cev thiab cov nplaum rau hauv cov tshuaj khib nyiab qhuav thiab cov hmoov putty. Txawm li cas los xij, vim nws cov khoom thermal gelling, MC tuaj yeem ua tsis tiav hauv qhov chaw kub kub.
HPMC: HPMC yog siv dav hauv kev tsim kho. Vim tias nws kuj muaj kev ruaj ntseg zoo nyob rau hauv qhov kub thiab txias, nws yog qhov tsim nyog rau cov xwm txheej uas yuav tsum tau ua kom sov siab dua, xws li cov nplais nplaum, rwb thaiv tsev mortars thiab self-leveling pem teb. .
Pharmaceutical thiab zaub mov
MC: Methylcellulose feem ntau yog siv los ua disintegrant thiab thickener rau cov ntsiav tshuaj hauv kev npaj tshuaj. Nws kuj yog siv rau hauv qee cov khoom noj ua cov thickener thiab fiber ntau ntxiv.
HPMC: HPMC muaj qhov zoo dua hauv kev lag luam tshuaj. Vim nws cov solubility ruaj khov thiab zoo biocompatibility, nws yog feem ntau siv nyob rau hauv sustained-tso zaj duab xis cov ntaub ntawv thiab capsule plhaub rau tshuaj. Tsis tas li ntawd, HPMC kuj tau siv dav hauv kev lag luam zaub mov, tshwj xeeb tshaj yog nyob rau hauv kev tsim cov neeg tsis noj nqaij capsules.
Coatings thiab xim sector
MC: MC muaj qhov ua kom tuab zoo dua thiab ua rau cov yeeb yaj kiab, tab sis nws qhov kev ruaj khov thiab kev hloov kho viscosity hauv kev daws tsis zoo li HPMC.
HPMC: HPMC yog dav siv nyob rau hauv cov xim thiab xim kev lag luam vim nws zoo heev thickening, emulsification thiab film-forming zog, tshwj xeeb tshaj yog raws li ib tug thickener thiab leveling tus neeg saib xyuas nyob rau hauv cov dej-raws li coatings, uas muaj peev xwm ho txhim kho kev tsim kho thiab nto ntawm txheej. . nyhuv.
5. Kev tiv thaiv ib puag ncig thiab kev nyab xeeb
Ob leeg MC thiab HPMC tau hloov kho los ntawm ntuj cellulose thiab muaj biodegradability zoo thiab kev tiv thaiv ib puag ncig. Ob leeg tsis muaj tshuaj lom thiab tsis muaj kev phom sij hauv kev siv thiab ua raws li kev tiv thaiv ib puag ncig, yog li lawv muaj kev nyab xeeb heev los siv rau hauv cov khoom noj, tshuaj thiab tshuaj pleev ib ce.
Txawm hais tias methylcellulose (MC) thiab hydroxypropylmethylcellulose (HPMC) zoo sib xws hauv cov qauv tshuaj, vim muaj cov pab pawg sib txawv, lawv solubility, thermal gelability, deg kev ua haujlwm, txheej txheem ntau lawm thiab daim ntawv thov sib txawv. Muaj qhov sib txawv pom tseeb hauv cov teb thiab lwm yam. MC yog tsim rau qhov kub thiab txias ib puag ncig thiab yooj yim thickening thiab dej tuav yuav tsum tau, thaum HPMC yog ntau haum rau complex industrial, tshuaj thiab siv cov ntaub ntawv vim nws zoo solubility thiab thermal stability.
Post lub sij hawm: Oct-25-2024