HPMC (Hydroxypropyl Methylcellulose) yog cov khoom siv ntau yam khoom siv dav siv hauv tshuaj, khoom noj, khoom siv hauv tsev thiab lwm yam haujlwm. HPMC cov khoom tuaj yeem muab faib ua ntau yam raws li cov ntawv thov sib txawv, ntawm cov uas muaj ntau dua yog K series thiab E series. Txawm hais tias ob qho tib si yog HPMC, lawv muaj qee qhov sib txawv hauv cov qauv tshuaj, lub cev thiab cov ntawv thov.
1. Qhov sib txawv ntawm cov qauv tshuaj
Cov ntsiab lus Methoxy: Qhov sib txawv tseem ceeb ntawm K series thiab E series HPMC yog lawv cov ntsiab lus methoxy. Cov ntsiab lus methoxy ntawm E series HPMC yog siab dua (feem ntau 28-30%), thaum cov ntsiab lus methoxy ntawm K series kuj qis (kwv yees 19-24%).
Cov ntsiab lus hydroxypropoxy: Hauv qhov sib piv, cov ntsiab lus hydroxypropoxy ntawm K series (7-12%) yog siab dua li ntawm E series (4-7.5%). Qhov sib txawv ntawm cov tshuaj muaj pes tsawg leeg ua rau qhov sib txawv ntawm kev ua haujlwm thiab kev siv ntawm ob.
2. Qhov txawv ntawm lub cev muaj zog
Solubility: Vim qhov sib txawv ntawm methoxy thiab hydroxypropoxy cov ntsiab lus, solubility ntawm K series HPMC yog me ntsis qis dua li ntawm E series, tshwj xeeb tshaj yog nyob rau hauv dej txias. E series yog ntau soluble hauv dej txias vim nws cov ntsiab lus methoxy ntau dua.
Gel kub: gel kub ntawm K series yog siab dua li ntawm E series. Qhov no txhais tau hais tias nyob rau hauv tib lub sijhawm, nws nyuaj dua rau K series HPMC los tsim cov gel. Cov gel kub ntawm E series yog qis dua, thiab hauv qee qhov kev siv tshwj xeeb, xws li cov khoom siv thermosensitive gel, E series yuav ua tau zoo dua.
Viscosity: Txawm hais tias viscosity feem ntau yog nyob ntawm qhov hnyav molecular ntawm HPMC, nyob rau hauv tib lub sijhawm, viscosity ntawm E series HPMC feem ntau yog siab dua li ntawm K series. Qhov sib txawv ntawm viscosity muaj qhov cuam tshuam loj rau cov khoom rheological thaum lub sij hawm kev npaj, tshwj xeeb tshaj yog thaum siv rau coatings thiab suspensions.
3. Qhov txawv ntawm daim ntawv thov teb
Vim qhov sib txawv ntawm cov qauv tshuaj thiab lub cev lub cev ntawm K series thiab E series HPMC, lawv cov ntawv thov hauv ntau qhov chaw kuj txawv.
Pharmaceutical teb: Hauv kev npaj tshuaj, E series HPMC feem ntau yog siv los ua cov khoom tseem ceeb ntawm kev npaj tawm-tso tawm. Qhov no yog vim nws tsis tshua muaj gelation kub thiab viscosity siab, uas ua rau nws tswj tau zoo dua cov tshuaj tso tawm tus nqi thaum tsim cov tshuaj tiv thaiv-tso zaj duab xis. K series yog siv ntau dua rau cov ntsiav tshuaj enteric-coated thiab ua cov khoom siv phab ntsa capsule, vim tias nws qhov kub siab gelation inhibits kev tso tawm cov tshuaj hauv cov kua txiv hmab txiv ntoo, uas yog qhov tsim nyog rau kev tso tawm cov tshuaj hauv txoj hnyuv.
Khoom noj khoom haus: Hauv kev lag luam zaub mov, E series HPMC feem ntau yog siv los ua cov thickener, stabilizer thiab emulsifier. Vim nws siab solubility thiab haum viscosity, nws yuav zoo dua dispersed thiab yaj nyob rau hauv cov zaub mov. K series feem ntau yog siv rau hauv cov khoom noj uas xav tau kom muaj kev ruaj ntseg nyob rau hauv qhov kub thiab txias, xws li cov khoom ci, vim nws qhov kub thiab txias.
Cov ntaub ntawv hauv tsev: Hauv cov khoom siv hauv tsev, K series HPMC feem ntau yog siv cov tshuaj khib nyiab qhuav thiab cov hmoov qhuav, ua cov dej tuav thiab cov thickener, tshwj xeeb tshaj yog rau lub sijhawm uas yuav tsum tau tsim los ntawm qhov kub thiab txias. E series yog tsim rau cov ntaub ntawv uas muaj rheological siab xws li cov xim hauv pem teb thiab cov coatings vim nws tsis tshua muaj gelation kub thiab viscosity siab.
4. Lwm yam cuam tshuam
Ntxiv rau qhov sib txawv saum toj no, kev siv tshwj xeeb ntawm cov kab sib txawv ntawm HPMC kuj tseem tuaj yeem cuam tshuam los ntawm cov yam ntxwv xws li qhov hnyav molecular, qib kev hloov pauv, thiab dispersibility. Tsis tas li ntawd, nyob rau hauv kev siv tswv yim, kev xaiv ntawm HPMC kuj yuav tsum tau xav txog nws compatibility nrog rau lwm cov khoom xyaw thiab nws cov kev cuam tshuam rau kev ua tau zoo ntawm cov khoom kawg.
Txawm hais tias K series thiab E series ntawm HPMC yog ob qho tib si hydroxypropyl methylcellulose, lawv qhia pom qhov sib txawv ntawm lub cev thiab cov chaw siv vim yog cov ntsiab lus sib txawv ntawm methoxy thiab hydroxypropoxy pawg. Kev nkag siab txog qhov sib txawv no yog qhov tseem ceeb rau kev xaiv hom HPMC txoj cai hauv cov ntawv thov.
Post lub sij hawm: Aug-13-2024