Hypromellose, tseem hu ua hydroxypropyl methylcellulose (HPMC), yog ib qho hluavtaws polymer muab los ntawm cellulose. Nws yog feem ntau siv nyob rau hauv ntau yam lag luam, nrog rau cov kws kho mob, tshuaj pleev ib ce, thiab khoom noj khoom haus. Hauv tshuaj, hypromellose muaj ntau daim ntawv thov vim nws cov khoom tshwj xeeb.
1. Taw qhia rau Hypromellose:
Hypromellose yog ib qho hydrophilic polymer uas tsim cov pob tshab, kua nplaum thaum yaj hauv dej. Nws yog feem ntau siv los ua cov khoom tsis muaj zog hauv cov tshuaj formulations los txhim kho cov yam ntxwv ntawm cov khoom xws li viscosity, stability, thiab bioavailability. Hypromellose yog dav siv nyob rau hauv cov ntaub ntawv ntawm qhov ncauj khoom noj, tshuaj ophthalmic npaj, thiab tshuaj pleev ib ce formulations.
2. Kev siv tshuaj:
a. Oral Solid Dosage Forms:
Hauv cov tshuaj noj qhov ncauj, hypromellose pab ntau lub hom phiaj:
Binder: Nws pab khi cov khoom xyaw tshuaj nquag (APIs) ua ke los tsim cov ntsiav tshuaj lossis tshuaj ntsiav.
Disintegrant: Hypromellose pab txhawb kev tawg ntawm cov ntsiav tshuaj lossis tshuaj ntsiav hauv plab hnyuv, txhawb cov tshuaj tso tawm thiab nqus.
Zaj duab xis yav dhau los: Nws yog siv los tsim ib daim nyias nyias, tiv thaiv zaj duab xis txheej ntawm cov ntsiav tshuaj rau kev tswj-tso formulations los yog los npog qhov tsis kaj siab saj.
b. Ophthalmic Kev Npaj:
Hauv qhov muag tee thiab tshuaj pleev, hypromellose ua haujlwm raws li:
Viscosity Modifier: Nws tsub kom lub viscosity ntawm qhov muag tee, muab lub sij hawm sib cuag nrog lub qhov muag nto thiab txhim kho kev xa tshuaj.
Lubricant: Hypromellose lubricates lub ntsej muag ntawm lub qhov muag, tshem tawm dryness thiab tsis xis nyob nrog rau tej yam kev mob xws li qhuav qhov muag syndrome.
c. Topical Formulations:
Hauv cov khoom siv tshuaj pleev ib ce xws li cream, gels, thiab tshuaj pleev, hypromellose ua raws li:
Gelling Agent: Nws pab tsim cov gel zoo li qhov sib xws, txhim kho kev sib kis thiab adhesion ntawm cov khoom rau ntawm daim tawv nqaij.
Moisturizer: Hypromellose khaws cov dej noo, hydrating ntawm daim tawv nqaij thiab tiv thaiv dej poob.
3. Mechanism of Action:
Hypromellose's mechanism ntawm kev txiav txim nyob ntawm nws daim ntawv thov:
Kev tswj qhov ncauj: Thaum noj, hypromellose swells thaum sib cuag nrog dej hauv plab hnyuv, txhawb kev tawg thiab tawg ntawm daim ntawv ntau npaum. Qhov no tso cai rau kev tswj kev tso tawm thiab nqus cov tshuaj.
Kev Siv Ophthalmic: Hauv qhov muag tee, hypromellose tsub kom lub viscosity ntawm cov tshuaj, ncua lub sij hawm sib cuag ntawm lub qhov muag thiab pab txhawb kev nqus tshuaj. Nws kuj muab lubrication los txo cov dryness thiab irritation.
Daim ntawv thov: Raws li tus neeg sawv cev gelling, hypromellose tsim cov txheej txheem tiv thaiv ntawm daim tawv nqaij, tiv thaiv kom tsis txhob ya raws thiab ua kom yooj yim rau kev nqus ntawm cov khoom xyaw nquag.
4. Kev Nyab Xeeb Profile:
Hypromellose feem ntau suav hais tias muaj kev nyab xeeb rau kev siv tshuaj, tshuaj pleev ib ce, thiab khoom noj khoom haus. Nws yog non-toxic, non-irritating, thiab non-allergenic. Txawm li cas los xij, cov tib neeg uas paub txog qhov tsis txaus ntseeg rau cov khoom siv cellulose yuav tsum zam cov khoom uas muaj hypromellose. Tsis tas li ntawd, qhov muag tee uas muaj hypromellose tuaj yeem ua rau qhov muag tsis pom kev ib ntus tom qab kev tswj hwm, uas feem ntau daws tau sai.
5. Tej yam tshwm sim:
Thaum hypromellose tau txais txiaj ntsig zoo los ntawm cov tib neeg feem ntau, qee qhov kev mob tshwm sim tsis tshua tshwm sim, suav nrog:
Kev Ua xua: Hauv cov tib neeg rhiab heev, cov tshuaj tiv thaiv tsis haum xws li khaus, liab, lossis o tuaj yeem tshwm sim thaum raug rau cov khoom uas muaj hypromellose.
Ocular Irritation: Qhov muag tee uas muaj hypromellose tuaj yeem ua rau mob me me, kub hnyiab, los yog stinging thaum instillation.
Kev cuam tshuam ntawm plab hnyuv: Hauv qee qhov tsis tshua muaj, cov tshuaj noj hauv qhov ncauj uas muaj hypromellose tuaj yeem ua rau mob plab xws li xeev siab, tsam plab, lossis raws plab.
Hypromellose yog ntau yam polymer nrog rau ntau yam kev siv tshuaj, nrog rau cov ntaub ntawv ntawm qhov ncauj, kev npaj kho qhov muag, thiab cov tshuaj pleev ib ce. Nws txhim kho cov yam ntxwv ntawm cov khoom xws li viscosity, stability, thiab bioavailability, txhim kho kev xa tshuaj thiab kev ua raws li tus neeg mob. Txawm hais tias nws tau siv dav thiab feem ntau muaj txiaj ntsig zoo rau kev nyab xeeb, cov tib neeg uas paub txog qhov tsis hnov tsw ntawm cellulose derivatives yuav tsum siv cov khoom uas muaj hypromellose nrog ceev faj. Zuag qhia tag nrho, hypromellose plays lub luag haujlwm tseem ceeb hauv cov qauv tshuaj niaj hnub no, ua rau muaj txiaj ntsig zoo thiab kev nyab xeeb ntawm cov tshuaj thiab cov khoom kho mob.
Post lub sij hawm: Mar-01-2024