Hydroxypropylmethylcellulose (HPMC) yog siv dav siv hluavtaws polymer pom nyob rau hauv ntau yam khoom xws li tshuaj pleev ib ce, tshuaj, tshuaj pleev ib ce thiab zaub mov. Nws yog tsim los ntawm kev hloov kho cellulose los ntawm cov tshuaj tiv thaiv ntawm propylene oxide thiab methyl chloride. HPMC muaj ntau yam khoom uas xav tau, xws li tsis muaj tshuaj lom, tsis ua rau khaus, biodegradable, thiab biocompatible. Ib qho ntawm nws cov khoom tshwj xeeb yog nws lub peev xwm los cuam tshuam lub teeb kis tau tus mob. Hauv tsab xov xwm no, peb tshawb txog ntau yam uas ua rau HPMCs cuam tshuam rau kev thauj mus los hauv lub teeb thiab kev siv lub peev xwm ntawm cov cuab yeej no.
Ib qho ntawm cov ntsiab lus tseem ceeb cuam tshuam rau lub teeb kis tau tus mob ntawm HPMC yog nws cov qauv molecular. HPMC yog ib tug branched polymer muaj li ntawm cellulose thiab methyl hydroxypropyl repeating units. Qhov hnyav molecular ntawm HPMC nyob ntawm nws qhov kev hloov pauv (DS), qhov nruab nrab ntawm hydroxypropyl thiab methyl pawg hauv ib chav cellulose. HPMC nrog DS siab dua muaj ntau pawg hydroxypropyl thiab methyl, uas ua rau muaj zog molecular hnyav dua thiab muaj kev cuam tshuam loj dua rau lub teeb xa hluav taws xob.
Lwm qhov tseem ceeb cuam tshuam rau lub teeb xa hluav taws xob yog qhov concentration ntawm HPMC hauv kev daws teeb meem. Thaum HPMC yaj nyob rau hauv dej, ib tug ntshiab thiab pob tshab kua yog tsim nyob rau hauv tsawg concentrations. Raws li qhov concentration nce, cov tshuaj yuav nkig ntau dua thiab qhov kev xa tawm yuav txo qis vim lub teeb tawg. Qhov luaj li cas ntawm cov nyhuv no nyob ntawm qhov hnyav molecular, DS thiab kub ntawm cov tshuaj.
Qhov thib peb yam uas cuam tshuam rau lub teeb transmittance yog pH ntawm cov tshuaj. HPMC yog ib qho amphoteric polymer uas tuaj yeem ua raws li cov kua qaub tsis muaj zog thiab lub hauv paus tsis muaj zog, nyob ntawm pH ntawm cov tshuaj. Thaum qis pH, cov hydroxypropyl thiab methyl pawg ntawm HPMC ua protonated, uas ua rau txo solubility thiab txo lub teeb transmittance. Thaum pH siab, cov pob txha cellulose ntawm HPMC yog deprotonated, uas ua rau muaj zog solubility thiab lub teeb transmittance.
Qhov thib plaub cuam tshuam rau lub teeb kis tau tus mob yog qhov muaj lwm cov tshuaj xws li ntsev, surfactants thiab co-solvents. Cov tebchaw no tuaj yeem cuam tshuam nrog HPMC, ua rau muaj kev hloov pauv hauv nws cov qauv molecular thiab solubility, yog li cuam tshuam rau lub teeb kis. Piv txwv li, ntxiv ntsev tuaj yeem ua kom lub zog ionic ntawm kev daws teeb meem, ua rau txo qis solubility thiab nce lub teeb tawg. Ntawm qhov tod tes, lub xub ntiag ntawm surfactants tuaj yeem hloov qhov nro ntawm qhov kev daws teeb meem, uas ua rau txo qis viscosity thiab nce hauv lub teeb xa hluav taws xob.
Cov khoom siv hluav taws xob ntawm HPMC muaj ntau yam kev siv. Hauv kev lag luam kws tshuaj, HPMC yog siv los ua cov thickener, binder thiab disintegrant hauv cov ntsiav tshuaj thiab tshuaj ntsiav. Nws lub peev xwm los cuam tshuam lub teeb kis tau tus mob ua rau nws muaj txiaj ntsig zoo li cov khoom siv txheej txheej uas tuaj yeem tiv thaiv cov khoom xyaw nquag los ntawm kev puas tsuaj los ntawm lub teeb. Lub teeb-scattering zog ntawm HPMC kuj ua rau nws yog ib tus neeg sib tw tsim nyog rau kev tswj xyuas cov tshuaj xa mus uas yuav tsum tau tso tawm cov khoom xyaw nquag.
Ntxiv nrog rau cov tshuaj, cov khoom siv hluav taws xob kis tau tus mob ntawm HPMC kuj tau siv hauv kev lag luam khoom noj. HPMC yog siv los hloov cov rog hauv cov khoom noj uas tsis muaj rog thiab calorie tsawg. Nws lub peev xwm los tsim cov viscous thiab ruaj khov gels hauv cov tshuaj aqueous ua rau nws muaj cov khoom xyaw zoo tagnrho rau cov khoom xws li zaub xam lav, mayonnaise thiab kua ntses. Lub teeb-scattering zog ntawm HPMC kuj tuaj yeem siv los ua kom pom huab cua hauv cov dej haus xws li kua txiv hmab txiv ntoo thiab dej haus kis las.
Hauv cov ntsiab lus, hydroxypropylmethylcellulose (HPMC) yog cov khoom siv hluavtaws muaj txiaj ntsig vim nws cov khoom tshwj xeeb, suav nrog kev muaj peev xwm cuam tshuam rau lub teeb kis. Cov yam ntxwv cuam tshuam rau lub teeb kis ntawm HPMC suav nrog nws cov qauv molecular, concentration, pH, thiab muaj lwm yam sib txuas. Lub teeb kis tau tus mob ntawm HPMC muaj ntau yam kev siv hauv kev lag luam tshuaj thiab zaub mov, suav nrog kev tswj cov tshuaj xa thiab cov khoom noj muaj roj tsawg. Raws li kev tshawb fawb txog cov khoom ntawm HPMCs txuas ntxiv mus, ntau daim ntawv thov yuav raug tshawb pom.
Post lub sij hawm: Aug-02-2023