Hydroxypropyl methylcellulose (HPMC) yog ib qho tseem ceeb ntawm cov cellulose ether, dav siv hauv kev tsim kho, tshuaj, zaub mov, tshuaj txhua hnub thiab lwm yam haujlwm. HPMC yog cov dej-soluble polymer uas tau txais los ntawm kev hloov kho tshuaj ntawm cov cellulose ntuj, nrog ntau lub cev thiab tshuaj lom neeg zoo heev.
1. Lub cev muaj zog
Qhov tsos thiab morphology: HPMC feem ntau yog cov hmoov dawb los yog daj me ntsis, tsis muaj ntxhiab, tsis qab, thiab muaj dej zoo. Nws tuaj yeem tsim cov yeeb yaj kiab los yog gel los ntawm ntau txoj kev ua, uas ua rau nws ua tau zoo hauv ntau daim ntawv thov.
Solubility: HPMC yooj yim soluble hauv dej txias, tab sis insoluble hauv dej kub. Thaum qhov kub nce mus txog ib theem (feem ntau yog 60-90 ℃), HPMC poob solubility hauv dej thiab tsim cov gel. Cov cuab yeej no ua rau nws muab cov nyhuv thickening thaum rhuab, thiab rov qab mus rau lub pob tshab aqueous tov lub xeev tom qab txias. Tsis tas li ntawd, HPMC yog ib nrab soluble hauv cov kuab tshuaj organic xws li ethanol.
Viscosity: Lub viscosity ntawm HPMC tov yog ib qho ntawm nws cov khoom tseem ceeb ntawm lub cev. Lub viscosity nyob ntawm nws qhov hnyav molecular thiab qhov concentration ntawm cov tshuaj. Feem ntau hais lus, qhov loj dua qhov hnyav molecular, qhov siab dua qhov viscosity ntawm cov tshuaj. HPMC muaj ntau yam viscosity thiab tuaj yeem hloov kho raws li kev thov tshwj xeeb, uas ua rau nws siv dav hauv kev tsim kho, tshuaj, tshuaj txhua hnub thiab lwm yam lag luam.
Cov cuab yeej ua yeeb yaj kiab: HPMC muaj cov cuab yeej ua yeeb yaj kiab zoo heev. Nws tuaj yeem tsim cov duab pob tshab thiab tawv tom qab yaj hauv dej lossis cov kuab tshuaj organic. Cov yeeb yaj kiab muaj cov roj zoo thiab muaj roj tsis kam, yog li nws feem ntau siv los ua cov khoom siv hauv cov khoom noj thiab tshuaj. Tsis tas li ntawd, HPMC zaj duab xis kuj muaj cov dej noo zoo thiab tuaj yeem tiv thaiv cov khoom sab hauv los ntawm cov dej noo.
Thermal stability: HPMC muaj thermal stability zoo. Txawm hais tias nws poob solubility thiab tsim cov gel ntawm qhov kub thiab txias, nws muaj thermal stability zoo nyob rau hauv lub xeev qhuav thiab tuaj yeem tiv taus qhov kub thiab txias yam tsis muaj decomposition. Qhov no feature muab nws zoo dua nyob rau hauv high-temperature processing.
2. Cov khoom siv tshuaj
Chemical stability: HPMC muaj cov tshuaj zoo nyob hauv chav tsev kub thiab ruaj khov rau cov kua qaub, alkalis thiab ntsev. Yog li ntawd, nyob rau hauv ntau cov tshuaj tiv thaiv los yog formulation systems, HPMC muaj peev xwm nyob ua ib tug stabilizer thiab tsis yooj yim rau reacts chemically nrog rau lwm cov khoom xyaw.
pH stability: HPMC tseem nyob ruaj khov nyob rau hauv thaj tsam ntawm pH 2-12, uas ua rau nws siv tau nyob rau hauv txawv pH ib puag ncig. HPMC yuav tsis raug hydrolysis lossis degradation nyob rau hauv acidic lossis alkaline tej yam kev mob, uas ua rau nws siv dav hauv zaub mov, tshuaj, thiab tshuaj pleev ib ce.
Biocompatibility thiab non-toxicity: HPMC muaj biocompatibility zoo thiab tuaj yeem siv nyab xeeb hauv tshuaj, zaub mov thiab lwm yam haujlwm uas muaj cov kev xav tau siab heev rau tib neeg kev noj qab haus huv. HPMC tsis muaj tshuaj lom thiab tsis ua rau khaus, thiab yuav tsis tawg mus rau hauv cov molecules me me los ntawm kev zom cov enzymes hauv lub cev, yog li nws tuaj yeem siv los ua tus neeg saib xyuas kev tso tawm rau cov tshuaj los yog cov thickener rau zaub mov.
Kev hloov kho tshuaj: HPMC muaj ntau pawg hydroxyl hauv nws cov qauv molecular, uas tuaj yeem txhim kho lossis muab cov khoom tshiab los ntawm kev hloov kho tshuaj ntxiv. Piv txwv li, los ntawm reacting nrog aldehydes los yog organic acids, HPMC tuaj yeem npaj cov khoom uas muaj cua sov siab dua lossis dej tsis kam. Tsis tas li ntawd, HPMC kuj tuaj yeem sib xyaw nrog lwm cov khoom siv polymers lossis cov khoom siv ntxiv los tsim cov ntaub ntawv sib xyaw kom tau raws li cov kev xav tau ntawm cov ntawv thov tshwj xeeb.
Moisture adsorption: HPMC muaj zog hygroscopicity thiab tuaj yeem nqus dej los ntawm huab cua. Cov cuab yeej no tso cai rau HPMC ob qho tib si tuab thiab tswj cov av noo ntawm cov khoom hauv qee daim ntawv thov. Txawm li cas los xij, qee zaum, kev nqus dej ntau dhau tuaj yeem cuam tshuam rau kev ruaj ntseg ntawm cov khoom, yog li cov nyhuv ntawm cov av noo ntawm qhov kev ua tau zoo ntawm HPMC yuav tsum xav txog thaum siv nws.
3. Daim ntawv thov teb thiab qhov zoo
Vim nws qhov tshwj xeeb lub cev thiab tshuaj lom neeg lub cev, HPMC muaj ntau yam kev siv nyiaj ntau hauv ntau qhov chaw. Piv txwv li, nyob rau hauv kev tsim kho, HPMC yog siv los ua cov thickener thiab dej-retaining tus neeg saib xyuas rau cov ntaub ntawv cement-based los txhim kho kev tsim kho thiab kav ntev ntawm cov ntaub ntawv hauv tsev; nyob rau hauv chaw ua tshuaj, HPMC feem ntau yog siv los ua cov ntsiav tshuaj nplaum, tswj kev tso tawm tus neeg sawv cev, thiab cov khoom siv tshuaj ntsiav tshuaj; nyob rau hauv cov zaub mov, nws yog siv raws li ib tug thickener, emulsifier, thiab stabilizer los txhim kho cov saj thiab kev ntxhib los mos ntawm cov zaub mov.
Hydroxypropyl methylcellulose plays lub luag haujlwm tsis tuaj yeem hloov pauv hauv ntau qhov kev lag luam vim nws lub cev zoo heev thiab tshuaj lom neeg. Nws ua tau zoo heev hauv dej solubility, zaj duab xis-forming zog, tshuaj stability, thiab lwm yam. ua rau HPMC ib tug indispensable multifunctional khoom nyob rau hauv kev lag luam thiab lub neej txhua hnub.
Post lub sij hawm: Aug-22-2024