Hydroxypropyl Methylcellulose (HPMC) yog ib qho nonionic cellulose ether dav siv hauv kev lag luam xws li kev tsim kho, tshuaj, zaub mov, tshuaj pleev ib ce thiab txheej. Nws versatility los ntawm nws cov cim physicochemical zog xws li thickening, bonding, film-forming, dej tuav thiab lubrication. Cov qib sib txawv ntawm HPMC feem ntau yog cais raws li lawv qib kev hloov pauv (DS) thiab cov ntsiab lus methoxy thiab hydroxypropyl, ntxiv rau lawv cov viscosity, particle loj thiab purity. Cov qib sib txawv ntawm HPMC no muaj cov yam ntxwv thiab kev siv sib txawv.
1. Cov ntsiab lus Methoxy thiab cov ntsiab lus hydroxypropyl
Cov ntsiab lus methoxy thiab hydroxypropyl hloov pauv ntawm HPMC yog qhov tseem ceeb uas txiav txim siab nws qhov kev ua tau zoo. Feem ntau hais lus, cov ntsiab lus methoxy ntawm HPMC yog nyob nruab nrab ntawm 19% thiab 30%, thiab cov ntsiab lus hydroxypropyl yog nruab nrab ntawm 4% thiab 12%. HPMC nrog cov ntsiab lus methoxy ntau dua feem ntau muaj cov dej solubility zoo dua thiab ua cov yeeb yaj kiab, thaum HPMC nrog cov ntsiab lus hydroxypropyl ntau dua muaj qhov elasticity zoo dua thiab tuav dej. Cov kev ntsuas no cuam tshuam ncaj qha rau kev siv HPMC. Piv txwv li, hauv kev tsim kho kev lag luam, cov ntsiab lus methoxy ntau dua yuav pab txhim kho cov dej tuav thiab kev tsim kho ntawm mortar; Hauv kev lag luam tshuaj, cov ntsiab lus hydroxypropyl ntau dua yuav pab txhim kho cov adhesion thiab tso tawm cov yam ntxwv ntawm cov tshuaj.
2. Qib viscosity
HPMC tuaj yeem muab faib ua cov viscosity tsawg, nruab nrab viscosity thiab qib viscosity siab raws li qhov viscosity ntawm nws cov tshuaj. Viscosity yog ib yam khoom tseem ceeb ntawm HPMC, feem ntau ntsuas los ntawm qhov pom tseeb viscosity ntawm 2% tov hauv milliPascal vib nas this (mPa.s).
Tsawg viscosity HPMC (xws li 5 mPa.s mus rau 100 mPa.s): Hom HPMC no feem ntau yog siv rau hauv cov ntawv thov uas yuav tsum tau ua kom qis qis dua, xws li tee, tshuaj tsuag thiab tshuaj pleev ib ce. Hauv cov ntawv thov no, HPMC cov viscosity tsawg tuaj yeem muab cov dej ntws zoo thiab cov khoom sib xws.
Nruab nrab viscosity HPMC (xws li 400 mPa.s mus rau 2000 mPa.s): Nruab nrab viscosity HPMC feem ntau yog siv rau hauv cov khoom siv hauv tsev, emulsions thiab cov nplaum los muab cov teebmeem tuab tuab, uas tuaj yeem sib npaug ntawm kev tsim kho thiab lub cev lub zog ntawm cov khoom kawg.
High viscosity HPMC (xws li 4000 mPa.s mus rau 200,000 mPa.s): High viscosity HPMC yog tsuas yog siv nyob rau hauv daim ntawv thov uas yuav tsum tau thickening, xws li mortar, putty, pobzeb adhesives thiab coatings. Nyob rau hauv cov khoom no, lub siab viscosity ntawm HPMC pab txhim kho nws cov dej tuav, anti-sagging thiab bonding zog.
3. Particle loj
Qhov loj me me ntawm HPMC kuj cuam tshuam rau nws cov ntawv thov. Feem ntau hais lus, HPMC tuaj yeem muab faib ua coarse particles thiab fine particles. Coarse particle HPMC feem ntau yog siv rau hauv daim ntawv thov uas yuav tsum tau sai sai dissolution los yog dispersion, thaum zoo particle HPMC yog haum rau cov khoom uas muaj siab dua cov kev xav tau rau cov tsos los yog xav tau ntau yam zoo tis.
Coarse-grained HPMC: HPMC nrog cov khoom loj dua muaj qhov sib xyaw sai dua hauv cov tshuaj khib nyiab qhuav thiab lwm cov teb, thiab tuaj yeem tsim cov tshuaj sib xws, yog li kev txhim kho kev tsim khoom.
Fine-grained HPMC: Fine-grained HPMC feem ntau yog siv hauv kev lag luam xws li xim, txheej thiab tshuaj pleev ib ce. Nws tuaj yeem tsim ib txheej txheej zaj duab xis ntau dua thaum lub sijhawm thov txheej txheem, txhim kho gloss thiab kev xav ntawm cov khoom.
4. Purity thiab qib tshwj xeeb
Raws li kev thov sib txawv, HPMC tuaj yeem ua kom huv ntxiv lossis ua haujlwm tau zoo. HPMC nrog purity siab dua feem ntau yog siv hauv kev lag luam tshuaj thiab zaub mov kom ntseeg tau tias muaj kev nyab xeeb thiab biocompatibility ntawm cov khoom. Tsis tas li ntawd, muaj qee cov HPMCs uas muaj cov haujlwm tshwj xeeb, xws li kev sib txuas ntawm HPMC, HPMC nto-kho, thiab lwm yam. Cov qib tshwj xeeb ntawm HPMC tuaj yeem muab kev tiv thaiv o ntau dua, muaj zog ua cov yeeb yaj kiab los yog cov kua qaub thiab alkali zoo dua.
Pharmaceutical grade HPMC: Pharmaceutical grade HPMC muaj qhov purity siab dua thiab tsim nyog rau cov ntsiav tshuaj, tshuaj ntsiav thiab kev npaj tso tawm, uas tuaj yeem txhim kho tus nqi tso tawm thiab ruaj khov ntawm cov tshuaj.
Khoom noj khoom haus qib HPMC: Qib zaub mov HPMC yog siv los ua zaub mov thickener, stabilizer thiab emulsifier kom muaj kev nyab xeeb thiab saj ntawm zaub mov.
Qib Industrial HPMC: HPMC siv hauv kev tsim kho, txheej txheej thiab lwm yam kev lag luam tuaj yeem muaj me me ntawm impurities, tab sis tuaj yeem muab kev lag luam ntau dua thiab kev ua haujlwm zoo.
5. Daim ntawv thov teb thiab xaiv
Cov qib sib txawv ntawm HPMC tau siv dav hauv kev tsim kho, tshuaj, khoom noj, tshuaj pleev ib ce thiab lwm yam haujlwm. Thaum xaiv HPMC qib tsim nyog, yam xws li viscosity, cov ntsiab lus hloov pauv, qhov loj me thiab purity yuav tsum raug txiav txim siab raws li qhov xav tau ntawm cov ntawv thov tshwj xeeb.
Kev tsim kho: Hauv cov khoom siv hauv tsev, HPMC feem ntau yog siv los ua cov thickener, dej retainer thiab binder. Rau cov ntawv thov xws li cov tshuaj khib nyiab qhuav thiab cov nplais nplaum nplaum, nws yog qhov tseem ceeb rau xaiv HPMC nrog cov viscosity tsim nyog thiab dej tuav.
Pharmaceutical teb: Hauv kev npaj tshuaj, HPMC yog siv los ua cov khoom siv capsule plhaub, ntsiav tshuaj txheej thiab nplaum. Nws yog ib qho tsim nyog los xaiv cov qib HPMC nrog cov tshuaj tsim nyog tso tawm thiab biocompatibility.
Khoom noj khoom haus thiab tshuaj pleev ib ce: Hauv kev lag luam khoom noj thiab tshuaj pleev ib ce, HPMC yog siv los ua cov thickener thiab stabilizer, thiab nws cov purity thiab kev nyab xeeb yog thawj qhov kev txiav txim siab.
Cov qib sib txawv ntawm Hydroxypropyl Methylcellulose (HPMC) muaj lawv tus kheej zoo thiab siv tau rau hauv daim ntawv thov. Kev nkag siab thiab xaiv cov qib HPMC uas tsim nyog tuaj yeem txhim kho kev ua tau zoo thiab zoo ntawm cov khoom thiab ua tau raws li qhov xav tau ntawm ntau yam kev lag luam thiab cov khoom siv.
Post lub sij hawm: Aug-21-2024