Hydroxypropyl Methylcellulose (HPMC) yog ib qho tseem ceeb ntawm cellulose derivative nrog ntau yam kev siv hauv ntau qhov kev lag luam. Nws muaj cov khoom zoo ntawm lub cev thiab tshuaj lom neeg, tsis muaj tshuaj lom, thiab ib puag ncig tus phooj ywg.
1. Cov khoom tseem ceeb ntawm HPMC
Cov qauv tshuaj thiab cov khoom siv lub cev
HPMC yog ib qho uas tsis yog-ionic cellulose ether tau los ntawm kev hloov tshuaj lom neeg ntawm ntuj cellulose. Nws cov qauv tsim muaj cov piam thaj, uas yog tsim los ntawm kev hloov qee pawg hydroxyl nrog hydroxypropyl thiab methyl pawg. Nws lub cev daim ntawv yog feem ntau dawb los yog daj me ntsis hmoov, uas yog yooj yim soluble nyob rau hauv txias thiab kub dej los tsim ib tug pob tshab los yog me ntsis turbid viscous kua.
Molecular Luj: HPMC muaj ntau yam ntawm qhov hnyav molecular, los ntawm qhov hnyav molecular (xws li 10,000 Da) mus rau siab molecular hnyav (xws li 150,000 Da), thiab nws cov khoom thiab kev siv kuj hloov raws li.
Solubility: HPMC tsim cov tshuaj colloidal nyob rau hauv dej txias, tab sis yog insoluble nyob rau hauv ib co organic solvents, thiab muaj zoo solubility thiab stability.
Viscosity: Viscosity yog ib yam khoom tseem ceeb ntawm HPMC, uas cuam tshuam los ntawm qhov hnyav molecular thiab hom thiab tus naj npawb ntawm cov khoom hloov. High-viscosity HPMC feem ntau yog siv los ua cov thickener thiab stabilizer, thaum tsis tshua muaj viscosity HPMC yog siv rau kev ua yeeb yaj kiab thiab kev sib txuas ua haujlwm.
Tshuaj stability
HPMC muaj tshuaj lom neeg ruaj khov, tuaj yeem tiv taus qhov yaig ntawm cov kua qaub, alkalis thiab cov organic solvents, thiab tsis yooj yim rau decompose lossis degrade. Qhov no tso cai rau nws tswj hwm nws txoj haujlwm hauv ntau qhov chaw ib puag ncig thiab tsim nyog rau ntau yam kev siv hauv kev lag luam.
Biocompatibility
Txij li HPMC yog muab los ntawm ntuj cellulose thiab tau hloov kho me ntsis, nws muaj biocompatibility zoo thiab tsis muaj tshuaj lom. Yog li ntawd, nws yog feem ntau siv rau hauv cov khoom noj, tshuaj thiab tshuaj pleev ib ce, ua tau raws li qhov yuav tsum tau muaj kev nyab xeeb.
2. Txoj kev npaj ntawm HPMC
Kev npaj ntawm HPMC feem ntau muab faib ua peb kauj ruam:
Kev kho alkali: ntuj cellulose yog kho nrog alkali tov (feem ntau yog sodium hydroxide) kom o thiab ua kom nws reactivity.
Etherification cov tshuaj tiv thaiv: Nyob rau hauv alkaline tej yam kev mob, cellulose undergoes etherification cov tshuaj tiv thaiv nrog methyl chloride thiab propylene oxide, qhia methyl thiab hydroxypropyl pawg los tsim hydroxypropyl methylcellulose.
Purification: Reaction byproducts thiab residual reagents raug tshem tawm los ntawm kev ntxuav, lim thiab ziab kom tau txais HPMC ntshiab.
Los ntawm kev tswj cov tshuaj tiv thaiv kab mob (xws li kub, lub sij hawm, reagent piv, thiab lwm yam), lub degree ntawm kev hloov thiab molecular hnyav ntawm HPMC tuaj yeem hloov kho kom tau txais cov khoom sib txawv.
3. Daim ntawv thov teb ntawm HPMC
Cov khoom siv hauv tsev
Hauv kev tsim kho kev lag luam, HPMC tau siv dav hauv cov cement mortar, gypsum khoom, coatings, thiab lwm yam. Nws lub luag haujlwm tseem ceeb suav nrog:
Thickening thiab dej tuav: Hauv mortar thiab txheej, HPMC tuaj yeem ua kom cov viscosity thiab txhim kho kev tsim kho, thaum muab cov dej tuav tau zoo thiab tiv thaiv kev tawg.
Txhim kho adhesion: Txhim kho qhov adhesion ntawm mortar thiab substrate thiab txhim kho kev tsim kho kom zoo.
Txhim kho kev tsim kho vaj tse: Ua rau kev tsim kho ntawm mortar thiab txheej yooj yim dua, ncua lub sijhawm qhib thiab txhim kho qhov smoothness.
Kev lag luam kws tshuaj
Daim ntawv thov ntawm HPMC hauv kev lag luam kws tshuaj yog feem ntau cuam tshuam txog kev npaj tshuaj, tshwj xeeb tshaj yog cov ntsiav tshuaj ntawm qhov ncauj thiab tshuaj ntsiav:
Kev tswj cov ntaub ntawv tso tawm: HPMC feem ntau yog siv los npaj cov ntsiav tshuaj tso tawm, thiab cov tshuaj tso tawm qeeb yog ua tiav los ntawm kev kho tus nqi tawg.
Tablet binders: Hauv cov ntsiav tshuaj ntau lawm, HPMC tuaj yeem siv los ua cov ntaub ntawv los muab cov ntsiav tshuaj tsim nyog thiab lub sijhawm tawg.
Zaj duab xis txheej: siv los ua cov khoom siv txheej rau cov ntsiav tshuaj los tiv thaiv oxidation thiab noo noo yaig ntawm cov tshuaj thiab txhim kho tshuaj stability thiab tsos.
Kev lag luam zaub mov
HPMC yog siv los ua khoom noj khoom haus hauv kev lag luam khoom noj, ua lub luag haujlwm ntawm thickener, emulsifier, stabilizer, thiab lwm yam.:
Thickener: siv rau hauv cov khoom siv mis nyuj, cov kua ntses, thiab lwm yam los muab kev zoo nkauj zoo nkauj thiab saj.
Emulsifier: hauv cov dej haus thiab dej khov, nws pab tsim kom muaj kev ruaj khov emulsified.
Zaj duab xis qub: hauv khoom qab zib thiab khoom qab zib, HPMC yog siv rau txheej thiab ci ci los txhim kho cov tsos thiab kev ntxhib los mos ntawm cov zaub mov.
Tshuaj pleev ib ce
Hauv tshuaj pleev ib ce, HPMC yog siv los npaj emulsions, cream, gels, thiab lwm yam.:
Thickening thiab stabilization: hauv cov tshuaj pleev ib ce, HPMC muab cov viscosity tsim nyog thiab ruaj khov, txhim kho kev ntxhib los mos thiab kis tau zoo.
Moisturizing: tuaj yeem tsim ib txheej moisturizing ntawm daim tawv nqaij kom ua rau cov nyhuv moisturizing ntawm cov khoom.
Cov tshuaj txhua hnub
HPMC kuj tseem siv rau hauv cov khoom siv tshuaj txhua hnub, xws li tshuaj ntxuav tes, khoom tu tus kheej, thiab lwm yam.:
Thickener: nyob rau hauv detergents, nws tsub kom lub viscosity ntawm cov khoom los tiv thaiv stratification.
Suspending tus neeg sawv cev: siv nyob rau hauv kev ncua kev kawm ntawv los muab kev ncua kev ruaj ntseg zoo.
4. Qhov zoo thiab cov nyom ntawm HPMC
Qhov zoo
Versatility: HPMC muaj ntau yam haujlwm thiab tuaj yeem ua haujlwm sib txawv hauv ntau qhov chaw, xws li thickening, dej tuav, ruaj khov, thiab lwm yam.
Biocompatibility: Tsawg toxicity thiab zoo biocompatibility ua rau nws haum rau siv nyob rau hauv cov zaub mov thiab tshuaj.
Ib puag ncig tus phooj ywg: muab los ntawm ntuj cellulose, biodegradable thiab ib puag ncig tus phooj ywg.
Kev sib tw
Tus nqi: Piv nrog rau qee cov khoom siv hluavtaws, HPMC muaj tus nqi siab dua, uas tuaj yeem txwv tsis pub siv dav hauv qee yam kev siv.
Cov txheej txheem ntau lawm: Cov txheej txheem npaj muaj cov tshuaj lom neeg cov tshuaj lom neeg thiab cov txheej txheem ua kom huv, uas yuav tsum tau tswj nruj me ntsis kom ntseeg tau cov khoom zoo.
5. Kev cia siab yav tom ntej
Nrog rau kev nce qib ntawm kev tshawb fawb thiab thev naus laus zis, daim ntawv thov kev cia siab ntawm HPMC yog qhov dav heev. Cov lus qhia kev tshawb fawb yav tom ntej yuav suav nrog:
Kev txhim kho ntawm HPMC hloov kho: Los ntawm kev hloov kho tshuaj lom neeg thiab kev siv thev naus laus zis, HPMC derivatives nrog cov haujlwm tshwj xeeb raug tsim los ua kom tau raws li cov kev thov tshwj xeeb.
Cov txheej txheem kev npaj ntsuab: Kev tshawb fawb ntau dua ib puag ncig tus phooj ywg thiab cov txheej txheem kev npaj tau zoo los txo cov nqi tsim khoom thiab ib puag ncig lub nra.
Cov cheeb tsam thov tshiab: Tshawb nrhiav daim ntawv thov ntawm HPMC hauv thaj chaw tshiab, xws li biomaterials, degradable ntim, thiab lwm yam.
Raws li ib qho tseem ceeb ntawm cov cellulose derivative, hydroxypropyl methylcellulose (HPMC) muaj cov khoom zoo ntawm lub cev thiab tshuaj lom neeg, muaj ntau hom kev siv thaj chaw thiab biocompatibility zoo. Hauv kev txhim kho yav tom ntej, los ntawm kev tsim kho thev naus laus zis thiab kev nthuav dav, HPMC xav tias yuav ua si nws qhov tshwj xeeb zoo hauv ntau thaj chaw thiab muab kev txhawb zog tshiab rau kev tsim kho kev lag luam.
Post lub sij hawm: Jun-25-2024