(1). Taw qhia
Hydroxypropyl methylcellulose (HPMC), tseem hu ua hydroxypropyl methylcellulose, yog ntau yam semi-synthetic cellulose ether nrog ntau yam kev siv tshuaj. Daim ntawv thov ntawm HPMC hauv kev lag luam tshuaj feem ntau yog vim nws lub cev zoo thiab tshuaj lom neeg, nrog rau kev tsim cov yeeb yaj kiab, gelling, thickening, adhesion thiab stability. Raws li ib qho inert thiab non-ionic compound, HPMC tuaj yeem muab kev tswj hwm kev tso tawm, saj daim npog qhov ncauj, kev ua yeeb yaj kiab, adhesion thiab tiv thaiv kev ua haujlwm hauv kev npaj tshuaj.
(2). Kev sib xyaw thiab kev npaj
HPMC yog hloov kho los ntawm ib feem methylation thiab hydroxypropylation ntawm cellulose los ntawm etherification ntawm cellulose nrog methanol thiab propylene oxide nyob rau hauv alkaline tej yam kev mob. Cov khoom ntawm HPMC, xws li viscosity, gelation kub thiab solubility, raug cuam tshuam los ntawm nws cov ntsiab lus hloov pauv thiab qhov hnyav molecular. Kev tsim cov tshuaj qib HPMC yuav tsum ua kom tau raws li cov qauv kev ua tau zoo los xyuas kom meej tias nws purity thiab sib xws kom tau raws li cov kev xav tau ntawm kev npaj tshuaj.
(3). Lub cev thiab tshuaj muaj zog
Cov cuab yeej ua yeeb yaj kiab: HPMC tuaj yeem tsim cov duab pob tshab, tsis muaj xim, hloov tau yooj yim.
Dej solubility: Nws yaj sai sai hauv dej txias, tab sis tsim cov gel hauv dej kub.
Kev tswj viscosity: Lub viscosity ntawm HPMC cov tshuaj tuaj yeem tswj tau los ntawm kev kho nws cov concentration thiab molecular hnyav.
Chemical inertness: Nws yog tshuaj ruaj khov nyob rau hauv feem ntau cov mob thiab tsis hnov mob nrog cov khoom xyaw tshuaj.
(4). Kev siv tshuaj
4.1 Tswj kev npaj tso tawm
HPMC plays lub luag haujlwm tseem ceeb hauv kev npaj-tso tawm thiab tswj-tso tawm. Nws tuaj yeem tsim cov gel barrier, tswj qhov kev sib cais ntawm cov tshuaj, thiab ua tiav lub hom phiaj ntawm kev ua kom lub sijhawm ntev ntawm cov tshuaj.
Qhov ncauj tswj-tso ntsiav tshuaj: Los ntawm kev sib xyaw nrog cov tshuaj, nws tsim cov matrix rau qeeb tso tshuaj. Raws li lub ntsiab excipient nyob rau hauv ib co sustained-tso ntsiav tshuaj, HPMC tuaj yeem maj mam hydrate thiab tsim ib txheej gel los tswj cov tshuaj tso tawm.
Microspheres thiab microcapsules: Raws li tus neeg sawv cev ua yeeb yaj kiab lossis ncua kev kawm stabilizer, nws yog siv los encapsulate cov tshuaj thiab txo qhov tso tawm.
4.2 Cov ntaub ntawv txheej
Raws li cov ntaub ntawv txheej, HPMC tuaj yeem muab cov tshuaj tiv thaiv, tswj kev tso tawm, txhim kho cov tsos, thiab npog cov ntxhiab tsw tsis zoo lossis saj.
Enteric txheej: HPMC tau ua ke nrog lwm cov polymers los ua cov txheej txheem enteric uas tiv taus cov kua txiv hmab txiv ntoo, kom ntseeg tau tias cov tshuaj tso tawm hauv cov hnyuv ntau dua li hauv plab.
Zaj duab xis txheej: Zaj duab xis txheej siv rau cov ntsiav tshuaj lossis granules los txhim kho kev ruaj ntseg thiab nqos kev nplij siab.
4.3 Cov ntaub ntawv
Cov khoom sib txuas ntawm HPMC ua rau nws zoo tagnrho rau kev npaj cov ntsiav tshuaj. Nws tuaj yeem txhim kho qhov compressibility ntawm cov hmoov thiab lub zog ntawm cov ntsiav tshuaj.
Cov ntsiav tshuaj: Siv los ua cov ntawv khi rau hauv ntub granulation kom ntseeg tau tias cov hmoov tuaj yeem raug compressed rau hauv cov ntsiav tshuaj muaj zog thiab zoo ib yam.
Kev npaj granular: HPMC tuaj yeem txhim kho qhov sib xws thiab lub zog ntawm granules thiab txo lub sijhawm tawg.
4.4 Thickeners thiab suspending agents
Raws li cov thickeners thiab tshem tawm cov neeg sawv cev, HPMC tuaj yeem txhim kho kev ruaj ntseg thiab sib xws ntawm cov kua npaj.
Cov kua hauv qhov ncauj: Txhim kho saj thiab ruaj khov thiab tiv thaiv nag lossis daus ntawm cov khoom xyaw.
Daim ntawv thov pleev xim: Siv los ua cov thickener hauv cream thiab gels los muab cov viscosity tsim nyog thiab kov.
4.5 Kev siv Ophthalmic
HPMC yog siv dav hauv kev npaj kho qhov muag, tshwj xeeb tshaj yog cov kua muag cuav thiab cov tshuaj pleev qhov muag.
Artificial kua muag: Raws li ib tug lubricant, nws muab ib tug xis moisturizing nyhuv thiab relieves qhuav qhov muag tsos mob.
Ophthalmic gel: Ua kom ntev lub sijhawm nyob ntawm cov tshuaj ntawm lub qhov muag thiab txhim kho kev ua tau zoo.
4.6 tsi Capsules
HPMC tuaj yeem siv los tsim cov tshuaj tsis noj nqaij (HPMC capsules) los hloov cov tshuaj gelatin, haum rau cov neeg tsis noj nqaij lossis cov neeg mob uas tsis haum rau cov khoom xyaw tsiaj.
Vegetarian capsules: Muab cov khoom zoo sib xws rau cov gelatin capsules thiab tsis cuam tshuam los ntawm cov teeb meem kev coj noj coj ua ntawm cov khoom xyaw tsiaj.
(5). Qhov zoo
Biocompatibility: HPMC tsis muaj tshuaj lom thiab tsis ua rau khaus, haum rau ntau hom tshuaj npaj.
Chemical stability: Tsis hnov mob nrog cov khoom xyaw tshuaj nquag thiab tswj cov tshuaj ua haujlwm.
Versatility: tuaj yeem siv los tswj kev tso tawm, txheej, sib txuas, thickening thiab ncua kev kawm.
Ib puag ncig tus phooj ywg: HPMC yog tsim los ntawm cov cellulose ntuj thiab yog rov ua dua tshiab thiab biodegradable.
6. Kev sib tw thiab kev cia siab
Txawm hais tias HPMC muaj ntau qhov zoo hauv kev npaj tshuaj, kuj tseem muaj kev nyuaj rau qee kis. Piv txwv li, nws lub cev lub cev yuav tsum tau kho kom zoo kom ntseeg tau tias cov tshuaj tso tawm tsis sib xws ntawm cov tshuaj hnyav. Tsis tas li ntawd, kev tshawb fawb yav tom ntej yuav tsom mus rau kev txhim kho ntxiv ntawm kev siv HPMC hauv cov tshuab xa tshuaj uas muaj txiaj ntsig zoo los ntawm kev hloov pauv molecular lossis sib txuas nrog lwm cov khoom ntxiv los txhim kho nws cov kev ua tau zoo.
Pharmaceutical qib hydroxypropyl methylcellulose (HPMC) plays lub luag hauj lwm irreplaceable nyob rau hauv niaj hnub kws formulations vim nws versatility thiab zoo heev physicochemical zog. Los ntawm kev tswj kev tso tawm, txheej rau kev sib txuas thiab thickening, daim ntawv thov ntau yam ntawm HPMC yog dav thiab nthuav dav. Nrog rau kev nce qib ntawm kev siv thev naus laus zis thiab kev tsim cov tshuaj tshiab, HPMC yuav ua lub luag haujlwm tseem ceeb hauv kev xa tshuaj rau yav tom ntej.
Post lub sij hawm: Jun-14-2024