Dab tsi yog hypromellose phthalate?

Hypromellose phthalate (HPMCP) yog ib hom tshuaj excipient uas yog siv nyob rau hauv formulation ntawm qhov ncauj noj cov ntaub ntawv, tshwj xeeb tshaj yog nyob rau hauv zus tau tej cov enteric-coated ntsiav tshuaj thiab tsiav tshuaj. Nws yog muab los ntawm cellulose, uas yog ib tug natural polymer uas tsim cov qauv ntawm cov nroj tsuag cell phab ntsa. HPMCP yog cov dej-soluble, anionic polymer uas feem ntau siv los ua cov khoom siv txheej txheej vim nws cov yeeb yaj kiab zoo heev, ruaj khov, thiab ua haujlwm rau cov kua hauv plab.

HPMCP tau pib thawj zaug thaum xyoo 1970s thiab txij li ntawd los tau dhau los ua cov khoom siv nkag rau hauv cov khoom siv dav siv vim nws cov khoom tshwj xeeb. Nws yog tsim los ntawm esterification ntawm hypromellose nrog phthalic acid thiab muaj nyob rau hauv ib tug ntau yam ntawm cov qib sib txawv, nyob ntawm seb lub degree ntawm phthalation thiab molecular hnyav ntawm lub polymer. Cov qib uas siv ntau tshaj plaws ntawm HPMCP yog HPMCP-55, HPMCP-50, thiab HPMCP-HP-55, uas muaj cov qib phthalation sib txawv thiab tsim nyog siv rau ntau hom kev tsim.

Lub luag haujlwm tseem ceeb ntawm HPMCP hauv cov tshuaj formulations yog los tiv thaiv cov khoom xyaw nquag ntawm cov tshuaj los ntawm degradation nyob rau hauv acidic ib puag ncig ntawm lub plab. Thaum cov ntsiav tshuaj lossis cov tshuaj ntsiav uas muaj HMCCP tau noj, cov txheej txheem tseem nyob hauv lub plab vim yog pH qis, tab sis thaum daim ntawv ntau npaum mus txog qhov ntau alkaline ib puag ncig ntawm cov hnyuv me, txheej pib yaj thiab tso tawm cov khoom xyaw nquag. Qhov kev tso tawm qeeb no pab kom ntseeg tau tias cov tshuaj xa mus rau qhov chaw ua haujlwm thiab tias nws cov txiaj ntsig tsis raug cuam tshuam los ntawm gastric acid.