HydroxyPropyyl methylcellulose (HPMC)Yog cov dej siv dej-soluble polymer nrog ntau yam kev siv, tshwj xeeb hauv cov khoom noj, khoom noj, thiab khoom noj kom zoo nkauj. Nws muaj peev xwm los ua cov txheej tuab, gel zoo li cov kev daws teeb meem thaum sib xyaw nrog dej ua rau nws muaj ntau yam khoom noj. Lub viscosity ntawm Kimacell® kho cov kev daws teeb meem plays lub luag haujlwm tseem ceeb hauv kev txiav txim siab lawv kev ua tau zoo hauv cov qauv sib txawv. Nkag siab txog cov yam ntxwv viscosity ntawm HPMC a cov kev daws teeb meem tseem ceeb rau kev ua kom zoo dua lawv cov kev lag luam.
1. Taw qhia rau hydroxyPropyyl Metthylcellulose (HPMC)
HydroxyPropyyl methylcellulose yog ib nrab hluavtaws derthetic derivative ntawm cellulose. Nws yog tsim los ntawm kev hloov chaw ntawm cellulose nrog hydroxyproprorey thiab methyl pawg. Qhov piv ntawm cov hloov no tuaj yeem sib txawv, ua rau cov qib kev sib txawv ntawm HPMC nrog cov yam ntxwv sib txawv, suav nrog viscosity. Cov qauv ib txwm muaj ntawm HPMC muaj cov cellulose caj qaum nrog hydroxypropyl thiab methyl pab pawg txuas rau chav dej qab zib.
HPMC yog siv ntau yam kev lag luam vim nws biocompatibility, muaj peev xwm los tsim cov gels, thiab yooj yim ntawm solubility hauv dej. Nyob rau hauv cov kev daws teeb meem aqueous, HPMC coj tus cwj pwm tsis yog-ionic, dej-soluble zog cuam tshuam rau cov tshuaj ntawm kev daws, tshwj xeeb yog viscosity.
2. Viscosity Cov yam ntxwv ntawm HPMC daws teeb meem
Lub viscos ntawm HPMC cov kev daws teeb meem yog cuam tshuam los ntawm ntau yam, nrog rau kev mob hpmc, qhov hnyav, thiab muaj ntsev lossis lwm yam kev sib txawv. Hauv qab no yog thawj yam tseemfwv uas tswj hwm tus neeg viscosity ntawm HPMC hauv cov kev daws teeb meem aqueous:
Concentration ntawm HPMC: Viscosity nce raws li cov concentration ntawm HPMC nce. Ntawm ntau dua qhov ntau, HPMC lwg me ntsis sib cuam tshuam ntau nrog txhua lwm yam, ua rau muaj kev tiv taus ntau dua.
Molecular qhov hnyav ntawm HPMC: Lub viscos ntawm HPMC cov kev daws teeb meem yog qhov tseeb correlated nrog molecular hnyav ntawm cov polymer. Qhov hnyav dua Molecular hnyav HPMC cov qib nyiam tsim cov kev daws teeb meem loj heev. Qhov no yog vim tias loj polymer molecules tsim ntau qhov tseem pheej tiv taus ntws vim lawv qhov kev sib txhuam tau zoo thiab kev sib txhuam.
Qho so: Viscosity feem tsawg zuj zus li kub nce ntxiv. Qhov no vim tias qhov kub siab dua ua rau txo cov rog sib txuam ntawm HPMC lwg me me, yog li txo lawv lub peev xwm los tawm tsam kev ntws.
Shear tus nqi: Lub viscos ntawm HPMC cov kev daws teeb meem yog Shear tus nqi-nyob ntawm, tshwj xeeb hauv cov kua tsis-Newtonian, uas yog cov kev daws teeb meem polymer. Ntawm cov nqi shear tsawg, HPMC cov kev daws teeb meem siab viscosity, thaum lub siab siab shear cov nqi, viscosity txo vim qhov kev coj ua theb tus cwj pwm.
Cov nyhuv ntawm ionic lub zog: Muaj cov electrolytes (xws li salts) hauv kev daws yuav tuaj yeem hloov lub viscosity. Qee cov ntsev tuaj yeem tshuaj ntsuam lub cev tsis muaj zog ntawm cov saw polymer, ua rau lawv sib sau ua ke thiab ua rau muaj kev txo qis.
3. Viscosity vs. concentration: kev sim ntsuas
Ib qho kev sim dav dav pom hauv HPMC aqueous cov kev daws teeb meem tau nthuav dav nrog nce polymer polymer. Cov kev sib raug zoo ntawm viscosity thiab cov kev xav tau piav qhia los ntawm kev sib npaug ntawm kev saib xyuas cov ntsiab lus sib npaug, uas feem ntau siv rau cov kev daws teeb meem polymer:
η = ANN \ eta = ac ^ nη = acn
Qhov twg:
η \ etaη yog viscosity
CCC yog cov concentration ntawm HPMC
AAA thiab NNN yog cov tsis tu ncua uas nyob ntawm hom HPMC tshwj xeeb thiab cov xwm txheej ntawm kev daws teeb meem.
Rau cov qis dua, txoj kev sib raug zoo yog linear, tab sis raws li kev xav tau nce, muaj kev cuam tshuam txog kev sib cuam tshuam ntau ntawm cov saw polymer.
4. Viscosity vs. molecular hnyav
Qhov hnyav molecular ntawm Kimacell®hpmc plays yog lub luag haujlwm tseem ceeb hauv nws cov yam ntxwv viscosity. Lub cev hnyav dua HPMC cov polymers zoo li tsim cov kev daws teeb meem ntau dua ntawm cov qib qis dua piv rau cov qib qis dua molecular. Lub viscosity ntawm cov kev daws teeb meem ua los ntawm high-molecular-hnyav HPMC tuaj yeem muaj ntau dua li cov kev daws teeb meem tau ua los ntawm qis-molecular-hnyav HPMC.
Piv txwv li, kev daws teeb meem ntawm HPMC nrog cov molecular hnyav ntawm 100,000 da yuav nthuav tawm viscosity dua li ib nrog txoj kev molecular hnyav dua li 50,000 da ntawm tib lub ntsiab lus.
5. Kub nyhuv rau viscosity
Kub muaj qhov cuam tshuam tseem ceeb rau kev viscosity ntawm HPMC cov kev daws teeb meem. Qhov nce hauv qhov ntsuas kub ua rau txo qis hauv kev daws viscosity. Qhov no yog feem ntau vim yog lub thermal lus tsa suab ntawm cov saw polymer, uas ua rau lawv txav chaw dawb paug, txo lawv txoj kev tawm tsam. Qhov cuam tshuam ntawm qhov kub ntawm viscosity feem ntau yog ntau siv ib qho kev sib npaug ntawm Arrhenius hom:
(t) = η0eart \ eta (t) = \ eta_0 e ^ {\ frac {rt}}} η (t) = ert0 ertea
Qhov twg:
η (t) \ eta (t) η (t) yog viscosity ntawm qhov kub ttt
η0 \ eta_0η0 yog qhov ua ntej tshaj plaws (viscosity ntawm infinite kub)
Eee_aea yog lub zog ua kom muaj zog
RRR yog cov roj tas li
TTT yog qhov kub meej
6. Rheological tus cwj pwm
Lub rheology ntawm HPMC a cov kev daws teeb meem yog feem ntau tau piav qhia raws li tsis yog-Newtonian, lub ntsiab lus lub hom phiaj yog tsis sib xws tab sis txawv txav nrog kev thov cov ntawv qaij. Ntawm cov nqi shear tsawg, HPMC cov kev daws teeb meem tau nthuav dav txog qhov siab viscrosity vim yog kev sib tw ntawm polymer. Txawm li cas los xij, raws li shear tus nqi nce ntxiv, qhov viscosity txo-ib qho tshwm sim hu ua shear thinning.
Tus cwj pwm no yog cov kev coj ua yog cov kev daws teeb meem polymer, suav nrog HPMC. Cov shear tus nqi ntawm viscosity tuaj yeem piav qhia siv lub hwj chim-txoj cai qauv:
η (γ Pab) = Kγ Pab tshwj xeeb-1 \ eta (\ {\ gamma} ^ {n \ γ (γ˙- 1
Qhov twg:
γ˙uam Kev Qhia {\ gamma} γ˙ yog tus nqi shear
KKK yog qhov ntsuas tau sib xws
NNN yog cov kev coj tus cwj pwm ntws (nrog n <1n <1n <1 rau shear thinning)
7. Viscosity ntawm HPMC Cov Ntsiab Lus: Rooj Sib Tham
Hauv qab no yog lub rooj sau cov ntsiab lus viscosity ntawm HPMC aqueous daws nyob rau hauv ntau qhov xwm txheej:
| Chaw ua uas tsis tau haus | Cov nyhuv ntawm viscosity |
| Kev xav ntsoov | Nce viscosity li concentration nce |
| Molecular hnyav | Siab dua molecular phaus nce viscosity |
| Qho so | Nce kub tsawg tsawg txo cov viscosity |
| Shear tus nqi | Cov nqi ntau dua txo cov viscosity (shear thinning tus cwj pwm) |
| Lub zog | Muaj cov ntsev yuav txo cov viscosity los ntawm kev tshuaj ntsuam tsis muaj zog ntawm cov rog polymer |
| Piv Txwv: viscosity ntawm HPMC (2% W / V) Solut | Viscosity (CP) |
| HPMC (Tsawg MW) | ~ 50-100 CP |
| HPMC (nruab nrab MW) | ~ 500-1,000 CP |
| HPMC (High MW) | ~ 2,000-5,000 cp |
Cov yam ntxwv viscosity ntawmHPMCCov kev daws teeb meem yog cuam tshuam los ntawm ntau yam, suav nrog kev xav, lub cev hnyav, ntsuas kub, thiab shear tus nqi. HPMC yog cov khoom siv HPM yog cov khoom siv ntau heev, thiab nws cov khoom siv rheological tuaj yeem tsim kho rau cov ntawv thov tshwj xeeb los ntawm kev kho cov kev ntsuas no. Nkag siab cov xwm txheej no tso cai rau kev siv zoo tshaj plaws ntawm Kimacell® tus neeg muaj kev lag luam, los ntawm kws tshuaj, los ntawm kws tshuaj rau cov khoom noj thiab cov tshuaj pleev ib ce. Los ntawm kev tswj hwm cov xwm txheej nyob rau hauv uas HPMC yog yaj, cov tuam ntxhab tuaj yeem ua tiav qhov xav tau thiab txaus siab rau lawv cov kev xav tau tshwj xeeb.
Lub Sijhawm Post: Jan-27-2025