Hydroxypropylcellulose (HPC) yog ib qho tseem ceeb ntawm cov cellulose derivative dav siv nyob rau hauv kws tshuaj, zaub mov thiab tshuaj pleev ib ce teb. Nws daim ntawv thov nyob rau hauv ncua kev kawm ntawv yog tshwj xeeb tshaj yog tseem ceeb, feem ntau los ntawm nws thickening, stabilizing thiab solubilizing zog los txhim kho lub stability ntawm ncua kev kawm ntawv.
Cov yam ntxwv tseem ceeb ntawm hydroxypropylcellulose
Hydroxypropyl cellulose yog ib qho nonionic cellulose ether tau los ntawm hydroxypropylation ntawm natural cellulose. Ib pawg hydrophilic hydroxypropyl yog nkag mus rau hauv nws cov qauv tshuaj, muab nws zoo solubility thiab thickening zog hauv dej. HPC muaj cov yam ntxwv hauv qab no:
Solubility zoo: HPC tuaj yeem yaj hauv ob qho tib si dej txias thiab dej kub, ua kom cov kua dej ntshiab thiab khov.
High biocompatibility: HPC muaj biocompatibility zoo thiab tsis muaj toxicity, yog li nws yog dav siv nyob rau hauv kev lag luam tshuaj thiab zaub mov.
Muaj zog thermal stability: HPC muaj thermal stability thiab muaj peev xwm tswj tau nws cov thickening thiab stabilizing zog nyob rau hauv ib tug tej yam kub kub.
thickening nyhuv
Ib qho ntawm cov haujlwm tseem ceeb ntawm HPC hauv kev ncua yog thickening. Los ntawm kev ntxiv qhov tsim nyog ntawm HPC rau qhov raug ncua, qhov viscosity ntawm cov kua tuaj yeem nce ntxiv, yog li txo qhov kev sib tw ceev ntawm cov khoom siv. Raws li Stokes 'txoj cai, qhov teeb meem ceev ntawm cov khoom yog inversely proportional rau viscosity ntawm cov kua. Yog li ntawd, los ntawm kev ua kom lub viscosity ntawm lub ncua kev kawm ntawv, kev hais lus ntawm hais yuav ua tau zoo ncua sij hawm thiab stability ntawm lub ncua kev kawm ntawv enhanced.
Cov nyhuv thickening ntawm HPC feem ntau yog los ntawm nws qhov hnyav molecular thiab cov nyhuv entanglement ntawm molecular chains. Thaum HPC yaj nyob rau hauv dej, cov saw ntev molecules nthuav thiab entangle nrog ib leeg nyob rau hauv cov tshuaj, tsim ib tug complex network qauv. Cov qauv hauv lub network no tuaj yeem ua rau muaj qhov viscosity ntawm cov tshuaj, ua rau nws nyuaj rau cov khoom txav mus rau hauv cov kua, yog li txhim kho qhov ruaj khov ntawm kev ncua.
Stabilizing nyhuv
Lwm lub luag haujlwm tseem ceeb ntawm HPC yog txhawm rau txhim kho kev ruaj ntseg ntawm kev ncua. Ntxiv nrog rau nws cov nyhuv thickening, HPC kuj muaj cov haujlwm zoo sib xws thiab muaj peev xwm los tsim cov txheej nplaum tiv thaiv. HPC molecules tuaj yeem adsorbed rau ntawm qhov chaw ntawm cov khoom siv los ua cov txheej txheem nplaum tiv thaiv kom tsis txhob muaj cov khoom sib sau ua ke.
Cov txheej nplaum tiv thaiv no tiv thaiv qhov kev ncua los ntawm electrostatic repulsion thiab steric hindrance cuam tshuam. Ua ntej, pawg hydroxypropyl nyob rau hauv HPC molecule tuaj yeem tsim hydrogen bonds nrog dej molecules, ua rau cov hydrophilicity ntawm cov particle nto thiab txhim kho cov dispersion ntawm cov khoom hauv dej. Qhov thib ob, lub xub ntiag ntawm HPC molecular chains yuav tsim ib qho kev thaiv lub cev ntawm cov khoom seem, tiv thaiv kev sib cuag ncaj qha ntawm cov khoom, yog li txo cov particle aggregation thiab sedimentation.
Solubilization
Cov nyhuv solubilizing ntawm HPC hauv kev ncua tsis tuaj yeem tsis quav ntsej. Rau qee cov tshuaj soluble tsis zoo lossis cov khoom xyaw nquag, HPC tuaj yeem ua kom lawv cov dej solubility hauv dej los ntawm kev tsim cov molecular inclusion complexes lossis micelles. Cov pab pawg hydroxypropyl nyob rau hauv HPC molecule tuaj yeem tsim kev sib cuam tshuam tsis muaj zog (xws li hydrogen bonds lossis van der Waals rog) nrog cov tshuaj tsis zoo hauv cov molecules, yog li txhim kho nws cov solubility hauv dej.
Los ntawm cov nyhuv solubilization no, HPC tuaj yeem tsis tsuas yog ua kom cov solubility ntawm cov khoom tsis zoo nyob rau hauv kev ncua, tab sis kuj txhim kho lawv cov kev faib tawm hauv cov kua, ntxiv dag zog rau kev ncua ntawm kev ncua.
Daim ntawv thov
Hauv kev lag luam kws tshuaj, HPC feem ntau yog siv ntau yam kev npaj tshuaj xws li kev tshem tawm qhov ncauj, txhaj tshuaj, thiab tshuaj kho qhov muag. Piv txwv li, nyob rau hauv qhov ncauj ncua kev kawm ntawv, HPC tuaj yeem txhim kho qhov kev ncua thiab kev ruaj ntseg ntawm cov tshuaj, kom ntseeg tau tias cov tshuaj tsis nyob twj ywm thaum lub sij hawm cia, yog li txhim kho kev ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj. Hauv kev txhaj tshuaj, HPC tuaj yeem nce bioavailability ntawm cov tshuaj thiab txhim kho lawv cov txiaj ntsig los ntawm kev solubilization.
Hauv kev lag luam khoom noj khoom haus, HPC feem ntau yog siv rau hauv cov khoom raug tshem tawm xws li kua txiv hmab txiv ntoo, cov khoom noj siv mis thiab cov khoom qab zib. HPC tuaj yeem txhim kho qhov viscosity thiab ruaj khov ntawm qhov raug ncua, tiv thaiv kev teeb tsa thiab stratification ntawm cov khoom siv, thiab xyuas kom cov khoom sib xws thiab saj ntawm cov khoom.
Hydroxypropylcellulose ua lub luag haujlwm tseem ceeb hauv kev txhim kho kev ncua kev ncua. Los ntawm nws cov thickening, stabilizing thiab solubilizing zog, HPC tuaj yeem ua rau kom cov viscosity ntawm kev ncua, txo qhov ceev ceev ntawm cov khoom siv, tsim cov nplaum nplaum tiv thaiv kom tsis txhob muaj cov khoom sib sau ua ke, thiab ua kom cov solubility ntawm cov khoom tsis zoo. Cov khoom no ua rau HPC dav siv hauv kev lag luam tshuaj, khoom noj thiab tshuaj pleev ib ce, ua ib feem tseem ceeb los txhim kho kev ruaj ntseg ntawm kev ncua.
Post lub sij hawm: Lub Xya hli ntuj-21-2024