HPMC (hydroxypropyl methylcellulose) yog ib qho khoom siv tshuaj uas nquag siv hauv kev tsim ntau hom tshuaj noj, suav nrog cov ntsiav tshuaj, tshuaj ntsiav, thiab cov khoom muag muag. Ib qho ntawm cov khoom tseem ceeb ntawm HPMC yog nws cov viscosity, uas cuam tshuam rau cov khoom ntawm cov khoom kawg. Kab lus no yuav tshawb txog kev sib raug zoo ntawm HPMC viscosity thiab kub thiab hais txog qee qhov kev ceev faj uas yuav tsum tau ua thaum siv cov khoom siv no.
Kev sib raug zoo ntawm HPMC viscosity thiab kub
HPMC yog hydrophilic polymer uas yog soluble hauv dej thiab lwm yam polar solvents. Thaum HPMC yaj nyob rau hauv dej, nws tsim ib tug viscous tov vim lub polymer lub siab molecular hnyav thiab high degree ntawm hydrophilicity. Lub viscosity ntawm HPMC cov kev daws teeb meem yog cuam tshuam los ntawm ntau yam, nrog rau cov concentration ntawm cov polymer, qhov kub thiab txias ntawm cov tshuaj, thiab pH ntawm cov kuab tshuaj.
Ib qho tseem ceeb cuam tshuam rau viscosity ntawm HPMC cov tshuaj yog qhov kub thiab txias. Lub viscosity ntawm HPMC cov kev daws teeb meem txo nrog qhov kub thiab txias. Qhov no yog vim hais tias ntawm qhov kub siab dua, cov saw hlau polymer ua kua dej ntau dua, ua rau tsawg dua cov tub rog sib txuas tuav cov saw hlau polymer ua ke. Yog li ntawd, lub viscosity ntawm cov tshuaj txo thiab fluidity ntawm cov tshuaj nce.
Kev sib raug zoo ntawm qhov kub thiab txias thiab HPMC viscosity tuaj yeem piav qhia los ntawm Arrhenius kab zauv. Arrhenius equation yog ib qho kev ua lej uas piav txog kev sib raug zoo ntawm tus nqi ntawm cov tshuaj tiv thaiv tshuaj thiab qhov kub ntawm qhov system. Rau HPMC cov kev daws teeb meem, qhov sib npaug Arrhenius tuaj yeem siv los piav qhia txog kev sib raug zoo ntawm cov kua viscosity thiab qhov system kub.
Arrhenius equation yog muab los ntawm:
k = Ae^(-Ea/RT)
qhov twg k yog tus nqi tas li, A yog qhov ua ntej exponential, Ea yog lub zog ua kom muaj zog, R yog cov pa tsis tu ncua, thiab T yog qhov kub ntawm qhov system. Lub viscosity ntawm HPMC cov kev daws teeb meem muaj feem xyuam rau qhov ntws ntawm cov kuab tshuaj los ntawm cov polymer matrix, uas yog tswj los ntawm tib txoj cai raws li tus nqi ntawm cov tshuaj tiv thaiv. Yog li ntawd, qhov sib npaug Arrhenius tuaj yeem siv los piav txog kev sib raug zoo ntawm kev daws viscosity thiab qhov system kub.
Tej yam yuav tsum nco ntsoov thaum siv HPMC
Thaum ua haujlwm nrog HPMC, ntau qhov kev ceev faj yuav tsum tau ua kom muaj kev nyab xeeb thiab ua haujlwm zoo ntawm cov khoom siv polymer. Cov kev ceev faj no suav nrog:
1. Siv cov cuab yeej tiv thaiv
Nws yog ib qho tseem ceeb uas yuav tsum tau siv cov cuab yeej tiv thaiv xws li hnab looj tes, tsom iav, thiab cov tsho hauv lab thaum tuav HPMC. Qhov no yog vim HPMC tuaj yeem ua rau tawv nqaij thiab qhov muag, thiab tuaj yeem ua rau muaj teeb meem ua pa yog tias nqus tau. Yog li ntawd, nws yog ib qho tseem ceeb uas yuav tsum tau ua cov kauj ruam los txo qhov kev pheej hmoo ntawm kev raug cov polymers.
2. Txuag HPMC kom raug
HPMC yuav tsum tau muab cia rau hauv qhov chaw txias, qhuav kom tsis txhob nqus dej noo hauv huab cua. Qhov no yog vim HPMC yog hygroscopic, lub ntsiab lus nws absorbs noo noo los ntawm nws ib puag ncig ib puag ncig. Yog tias HPMC nqus dej ntau dhau, nws tuaj yeem cuam tshuam rau viscosity thiab cov khoom ntawm cov khoom kawg.
3. Ua tib zoo saib xyuas cov concentration thiab kub
Thaum tsim nrog HPMC, nco ntsoov ua tib zoo saib xyuas qhov concentration thiab kub ntawm cov tshuaj. Qhov no yog vim qhov viscosity ntawm HPMC cov kev daws teeb meem feem ntau txiav txim siab los ntawm cov xwm txheej no. Yog tias qhov concentration lossis kub siab dhau los yog qis dhau, nws yuav cuam tshuam rau viscosity thiab cov khoom ntawm cov khoom kawg.
4. Siv cov txheej txheem ua kom tsim nyog
Thaum ua HPMC, nws yog ib qho tseem ceeb uas yuav tsum tau siv cov txheej txheem tsim nyog los xyuas kom muaj kev nyab xeeb thiab ua haujlwm zoo ntawm cov khoom siv polymer. Qhov no yuav suav nrog kev siv cov txheej txheem sib tov qis los tiv thaiv cov polymer shearing lossis tawg, lossis siv cov txheej txheem ziab kom tsim nyog kom tshem tawm cov dej noo ntau dhau los ntawm cov khoom kawg.
5. Tshawb xyuas kev sib raug zoo
Thaum siv HPMC ua ib qho khoom siv ntxiv, nws yog ib qho tseem ceeb uas yuav tsum tau kuaj xyuas kev sib raug zoo nrog lwm cov khoom ntxiv thiab cov khoom xyaw nquag hauv cov qauv. Qhov no yog vim HPMC tuaj yeem cuam tshuam nrog lwm cov khoom xyaw hauv kev tsim, cuam tshuam rau kev ua haujlwm thiab kev ruaj ntseg ntawm cov khoom kawg. Yog li ntawd, nws yog ib qho tseem ceeb rau kev tshawb fawb txog kev sib raug zoo txhawm rau txheeb xyuas cov teeb meem uas muaj peev xwm ua ntej pib ua cov txheej txheem.
nyob rau hauv xaus
Lub viscosity ntawm HPMC cov kev daws teeb meem yog cuam tshuam los ntawm ntau yam, suav nrog concentration, kub, thiab pH. Lub viscosity ntawm HPMC cov kev daws teeb meem txo qis nrog qhov kub thiab txias vim muaj zog ntxiv ntawm cov saw hlau polymer. Thaum ua haujlwm nrog HPMC, nws yog ib qho tseem ceeb uas yuav tsum tau ceev faj kom tsim nyog kom muaj kev nyab xeeb thiab ua haujlwm zoo ntawm cov khoom siv polymer. Cov kev ceev faj no suav nrog kev siv cov cuab yeej tiv thaiv, khaws cia HPMC kom zoo, ua tib zoo saib xyuas cov ntsiab lus thiab qhov kub thiab txias, siv cov txheej txheem tsim nyog, thiab tshuaj xyuas kev sib raug zoo nrog lwm cov khoom xyaw hauv cov mis. Los ntawm kev ua raws li cov kev ceev faj no, HPMC tuaj yeem siv los ua ib qho khoom noj muaj txiaj ntsig hauv ntau hom tshuaj noj.
Post lub sij hawm: Sep-25-2023