Tablet txheej nplaum HPMC

Hydroxypropyl methyl cellulose (HPMC) yog cov ntsiav tshuaj txheej nplaum uas siv ntau hauv kev lag luam kws tshuaj. HPMC yog hluavtaws, dej-soluble polymer uas yog muab los ntawm cellulose, ib tug natural polymer pom nyob rau hauv cov nroj tsuag lub nceeg vaj. Cov txheej txheem kev hloov kho tshuaj muaj xws li kev hloov pauv ntawm qee pawg hydroxyl hauv cellulose nrog hydroxypropyl pawg, ua rau nws cov dej-soluble thiab tso cai rau nws siv rau ntau yam kev siv.

Cov ntsiav tshuaj txheej yog ib kauj ruam tseem ceeb hauv cov txheej txheem tsim cov ntsiav tshuaj, vim nws tiv thaiv cov ntsiav tshuaj los ntawm noo noo, txhim khu nws lub txee lub neej, thiab txhim kho nws cov tsos thiab tuav cov khoom. HPMC yog siv los ua cov nplaum rau hauv cov txheej txheem txheej txheem los pab khi cov txheej txheem rau cov ntsiav tshuaj thiab txhim kho cov adhesion ntawm txheej rau cov ntsiav tshuaj nto.

Ib qho txiaj ntsig tseem ceeb ntawm kev siv HPMC ua cov ntsiav tshuaj txheej nplaum yog nws lub peev xwm los tsim kom muaj zog, ruaj khov nrog cov ntsiav tshuaj. Thaum ntxiv rau txheej txheej, HPMC pab txhawm rau khi lwm cov khoom ntawm cov txheej txheem ua ke, muab kev tiv thaiv kev tiv thaiv uas pab tiv thaiv cov ntsiav tshuaj los ntawm kev tawg lossis tawg. Tsis tas li ntawd, HPMC tseem tuaj yeem pab txo qis cov dej noo uas nqus los ntawm cov ntsiav tshuaj, uas tuaj yeem ua rau cov ntsiav tshuaj tawg lossis deformed dhau sijhawm.

Lwm qhov kom zoo dua ntawm kev siv HPMC ua cov ntsiav tshuaj txheej nplaum yog nws cov versatility. HPMC muaj nyob rau hauv ntau qib, txhua tus muaj cov khoom sib txawv uas ua rau nws tsim nyog rau kev siv sib txawv. Piv txwv li, tsis tshua muaj viscosity HPMC feem ntau yog siv nyob rau hauv daim ntawv thov uas yuav tsum tau ib tug tsawg viscosity tov, xws li nyob rau hauv lub chaw tsim tshuaj paus ntawm low-viscosity adhesives. Nruab nrab viscosity HPMC feem ntau yog siv rau hauv cov ntawv thov uas xav tau cov tshuaj viscosity nruab nrab, xws li hauv kev tsim cov ntsiav tshuaj txheej. High viscosity HPMC feem ntau yog siv rau hauv cov ntawv thov uas yuav tsum tau muaj cov tshuaj viscosity siab, xws li hauv kev tsim cov khoom tuab thiab creamy, xws li tshuaj zawv plaub hau thiab tshuaj pleev ib ce.

Ntxiv nrog rau nws cov kev ua tau zoo, HPMC kuj yog qhov kev xaiv pheej yig thiab raug nqi rau cov ntsiav tshuaj txheej. Nws yog ib qho khoom siv yooj yim thiab tus nqi qis uas yooj yim rau kev ua haujlwm nrog, ua rau nws yog ib qho kev xaiv nrov rau cov tuam txhab ntsiav tshuaj. Tsis tas li ntawd, HPMC tsis muaj tshuaj lom thiab biocompatible, ua rau nws muaj kev nyab xeeb rau kev siv hauv kev lag luam tshuaj.

Ib qho ntawm cov teeb meem hauv kev siv HPMC ua cov ntsiav tshuaj txheej nplaum yog tias nws tuaj yeem cuam tshuam los ntawm ib puag ncig, xws li kub thiab av noo. Yog tias cov txheej txheej raug kub los yog cov av noo siab, HPMC tuaj yeem yaj, ua rau cov txheej ua kom tawv thiab tawg lossis tawg. Txhawm rau kov yeej qhov kev sib tw no, cov chaw tsim khoom lag luam tuaj yeem siv kev sib xyaw ntawm HPMC thiab lwm yam polymers, xws li Eudragit lossis polyvinyl cawv, los muab lub zog ntxiv thiab ruaj khov rau txheej.

Nyob rau hauv xaus, HPMC yog ib tug ntau yam thiab nqi-zoo ntsiav tshuaj txheej nplaum uas yog dav siv nyob rau hauv kev lag luam kws tshuaj. Nrog nws lub peev xwm los tsim kom muaj kev sib raug zoo nrog cov ntsiav tshuaj, nws muaj ntau yam, thiab nws cov nqi qis, HPMC yog cov khoom siv tseem ceeb uas yuav pab txhim kho cov khoom ntawm cov ntsiav tshuaj txheej thiab txhim kho tag nrho cov khoom zoo ntawm cov ntsiav tshuaj.