Kawm txog tus cwj pwm rheological ntawm konjac glucomannan thiab hydroxypropyl methylcellulose compound system

Cov txheej txheem sib xyaw ntawm konjac glucomannan (KGM) thiab hydroxypropyl methylcellulose (HPMC) tau raug coj los ua cov khoom tshawb fawb, thiab kev ntsuas tsis tu ncua ntawm lub xeev, zaus thiab ntsuas kub cheb tau ua rau ntawm qhov system los ntawm kev sib hloov rheometer. Kev cuam tshuam ntawm kev daws qhov feem ntau thiab qhov sib piv ntawm viscosity thiab rheological zog ntawm KGM / HPMC compound system tau txheeb xyuas. Cov txiaj ntsig tau pom tias KGM / HPMC cov txheej txheem sib xyaw yog cov kua dej tsis yog-Newtonian, thiab qhov nce ntawm cov feem ntau thiab KGM cov ntsiab lus ntawm lub kaw lus txo qhov fluidity ntawm cov tshuaj sib xyaw thiab ua kom cov viscosity nce. Nyob rau hauv lub xeev sol, KGM thiab HPMC molecular chains tsim ib tug ntau compact qauv los ntawm hydrophobic kev sib tshuam. Ua kom cov kab ke loj feem ntau thiab KGM cov ntsiab lus yog qhov tsim nyog rau kev tswj xyuas qhov ruaj khov ntawm cov qauv. Nyob rau hauv qhov qis pawg feem ntau, nce cov ntsiab lus ntawm KGM yog qhov zoo rau kev tsim cov thermotropic gels; thaum nyob rau hauv lub siab loj feem ntau, nce cov ntsiab lus ntawm HPMC yog qhov tsim nyog rau kev tsim cov thermotropic gels.

Lo lus tseem ceeb:konjac glucomannan; hydroxypropyl methylcellulose; compound; tus cwj pwm rheological

Ntuj polysaccharides yog siv dav hauv kev lag luam khoom noj vim lawv cov thickening, emulsifying thiab gelling zog. Konjac glucomannan (KGM) yog cov nroj tsuag ntuj polysaccharide, muaj li ntawmβ-D-glucose thiabβ-D-mannose nyob rau hauv ib tug ratio ntawm 1.6: 1, ob yog txuas los ntawmβ-1,4 glycosidic bonds, hauv C- Muaj me me ntawm acetyl ntawm txoj hauj lwm 6 (kwv yees li 1 acetyl rau txhua 17 seem). Txawm li cas los xij, qhov siab viscosity thiab cov dej tsis zoo ntawm KGM aqueous tov txwv nws daim ntawv thov hauv kev tsim khoom. Hydroxypropyl methylcellulose (HPMC) yog propylene glycol ether ntawm methylcellulose, uas belongs rau non-ionic cellulose ether. HPMC yog zaj duab xis-tsim, dej-soluble, thiab rov ua dua tshiab. HPMC muaj cov viscosity tsawg thiab gel lub zog ntawm qhov kub thiab txias, thiab kev ua haujlwm tsis zoo, tab sis tuaj yeem tsim cov viscosity zoo li gel ntawm qhov kub thiab txias, yog li ntau cov txheej txheem tsim khoom yuav tsum tau ua ntawm qhov kub thiab txias, ua rau muaj zog ntau lawm. Cov nqi tsim khoom yog siab. Cov ntaub ntawv qhia tau hais tias qhov tsis hloov pauv mannose ntawm KGM cov saw hlau molecular tuaj yeem tsim ib qho kev sib txuas tsis muaj zog hauv cheeb tsam hydrophobic nrog cov pab pawg hydrophobic ntawm HPMC molecular saw los ntawm kev sib cuam tshuam hydrophobic. Cov qauv no tuaj yeem ncua sijhawm thiab qee qhov tiv thaiv cov thermal gelation ntawm HPMC thiab txo cov gel kub ntawm HPMC. Tsis tas li ntawd, nyob rau hauv qhov kev pom ntawm cov khoom tsis muaj viscosity ntawm HPMC ntawm qhov kub thiab txias, nws tau kwv yees tias nws cov khoom sib xyaw nrog KGM tuaj yeem txhim kho cov khoom muaj viscosity ntawm KGM thiab txhim kho nws cov kev ua haujlwm. Yog li ntawd, daim ntawv no yuav tsim ib lub KGM/HPMC compound system los tshawb txog kev cuam tshuam ntawm cov kev daws teeb meem feem ntau thiab compound ratio ntawm lub rheological zog ntawm KGM/HPMC system, thiab muab ib tug theoretical reference rau daim ntawv thov ntawm KGM / HPMC compound system nyob rau hauv kev lag luam zaub mov.

1. Cov ntaub ntawv thiab cov txheej txheem

1.1 Cov ntaub ntawv thiab cov tshuaj reagents

Hydroxypropyl methylcellulose, KIMA CHEMICAL CO., LTD, pawg feem 2%, viscosity 6 mPa·s; methoxy pawg feem 28% ~ 30%; hydroxypropyl pawg feem 7.0% ~ 12%.

Konjac glucomannan, Wuhan Johnson Konjac Food Co., Ltd., 1 wt% aqueous kua viscosity≥28 000 mPa·s.

1.2 Cov cuab yeej thiab cov cuab yeej siv

MCR92 rotational rheometer, Anton Paar Co., Ltd., Austria; UPT-II-10T ultrapure dej tshuab, Sichuan Youpu Ultrapure Technology Co., Ltd.; AB-50 hluav taws xob analytical tshuav nyiaj li cas, Swiss Mette tuam txhab; LHS-150HC qhov kub thiab txias da dej, Wuxi Huaze Technology Co., Ltd.; JJ-1 Electric Stirrer, Jintan Medical Instrument Factory, Jiangsu Province.

1.3 Kev npaj cov tshuaj tov

Hnyav HPMC thiab KGM hmoov nrog ib qho kev sib xyaw ua ke (qhov sib piv: 0: 10, 3: 7, 5: 5, 7: 3, 10: 0), maj mam ntxiv rau hauv dej deionized hauv 60°C dej da dej, thiab do rau 1.5 ~ 2 h kom nws sib cais sib npaug, thiab npaj 5 hom kev daws teeb meem nrog tag nrho cov khoom seem ntawm 0.50%, 0.75%, 1.00%, 1.25%, thiab 1.50%, feem.

1.4 Kev ntsuam xyuas ntawm cov khoom rheological ntawm cov tshuaj tov

Steady-state shear test: Lub rheological nkhaus ntawm KGM / HPMC compound tov tau ntsuas siv CP50 lub khob hliav qab thiab phaj, qhov sib txawv ntawm cov phaj sab sauv thiab qis tau kho ntawm 0.1 hli, ntsuas kub yog 25°C, thiab qhov shear npaum li cas yog 0.1 txog 100 s-1.

Kev kuaj kab mob (kev txiav txim siab ntawm thaj tsam viscoelastic): Siv PP50 phaj los ntsuas cov kab tawm viscoelastic cheeb tsam thiab kev hloov pauv txoj cai ntawm KGM / HPMC compound tov, teem qhov sib nrug mus rau 1.000 hli, tsau zaus rau 1Hz, thiab ntsuas kub txog 25°C. Cov kab mob yog 0.1% ~ 100%.

Zaus cheb: Siv lub phaj PP50 los ntsuas qhov kev hloov pauv hloov thiab zaus dependence ntawm KGM/HPMC compound tov. Qhov sib nrug yog teem rau 1.000 hli, lub lim yog 1%, ntsuas kub yog 25°C, thiab qhov ntau zaus yog 0.1-100 Hz.

Kev ntsuas kub: Cov qauv ntsuas thiab qhov ntsuas kub ntawm KGM / HPMC compound tov tau ntsuas siv PP50 phaj, qhov sib nrug tau teem rau 1.000 hli, qhov ruaj khov zaus yog 1 Hz, qhov deformation yog 1%, thiab qhov kub ntawm 25%. rau 90°C.

2. Cov txiaj ntsig thiab kev tshuaj xyuas

2.1 Flow curve analysis of KGM/HPMC compound system

Viscosity piv rau shear tus nqi nkhaus ntawm KGM/HPMC cov kev daws teeb meem nrog sib txawv compounding ratios sib txawv pawg. Cov kua dej uas nws cov viscosity yog ib qho kev ua haujlwm ntawm kev sib tsoo yog hu ua Newtonian kua, txwv tsis pub lawv hu ua non-Newtonian kua. Nws tuaj yeem pom los ntawm qhov nkhaus uas qhov viscosity ntawm KGM tov thiab KGM / HPMC compound tov txo nrog qhov nce ntawm shear npaum li cas; Qhov siab dua ntawm KGM cov ntsiab lus, qhov siab dua qhov system loj feem, thiab qhov pom tseeb dua qhov tshwm sim ntawm cov txheej txheem ntawm cov tshuaj. Qhov no qhia tau hais tias KGM thiab KGM/HPMC compound system yog non-Newtonian kua, thiab cov kua hom KGM/HPMC compound system yog txiav txim siab los ntawm KGM.

Los ntawm cov ndlwg Performance index thiab viscosity coefficient ntawm KGM/HPMC cov kev daws teeb meem nrog ntau pawg pawg thiab sib txawv compound ratios, nws yuav pom tau hais tias cov n qhov tseem ceeb ntawm KGM, HPMC thiab KGM/HPMC compound systems yog tag nrho cov tsawg tshaj li 1, qhia tias cov kev daws teeb meem yog. tag nrho cov kua pseudoplastic. Rau lub KGM / HPMC compound system, qhov nce ntawm qhov loj feem ntawm lub system yuav ua rau entanglement thiab lwm yam kev cuam tshuam ntawm HPMC thiab KGM molecular chains nyob rau hauv cov tshuaj, uas yuav txo tau cov kev mus los ntawm molecular chains, yog li txo tus nqi ntawm n. qhov system. Nyob rau tib lub sijhawm, nrog rau qhov nce ntawm KGM cov ntsiab lus, kev sib cuam tshuam ntawm KGM molecular chains hauv KGM / HPMC system tau txhim kho, yog li txo nws txoj kev txav mus los thiab ua rau txo qis n tus nqi. Ntawm qhov tsis sib xws, K tus nqi ntawm KGM / HPMC cov tshuaj sib xyaw ua ke nce ntxiv nrog kev nce ntxiv ntawm cov ntsiab lus ntawm cov ntsiab lus thiab KGM cov ntsiab lus, uas yog vim qhov nce ntawm qhov system loj feem thiab KGM cov ntsiab lus, uas ob qho tib si nce cov ntsiab lus ntawm hydrophilic pawg nyob rau hauv lub system. , nce kev sib cuam tshuam ntawm molecular hauv cov saw hlau molecular thiab nruab nrab ntawm cov saw hlau, yog li ua kom lub vojvoog hydrodynamic ntawm cov molecule, ua rau nws tsis tshua muaj kev taw qhia nyob rau hauv qhov kev txiav txim ntawm sab nraud shear quab yuam thiab nce viscosity.

Tus nqi theoretical ntawm xoom-shear viscosity ntawm KGM / HPMC compound system tuaj yeem xam raws li cov ntsiab lus ntawm logarithmic summation saum toj no, thiab nws qhov kev sim muaj peev xwm tuaj yeem tau txais los ntawm Carren haum extrapolation ntawm viscosity-shear tus nqi nkhaus. Muab piv rau qhov kwv yees tus nqi ntawm xoom-shear viscosity ntawm KGM / HPMC compound system nrog sib txawv pawg feem ntau thiab sib txawv compounding piv nrog rau qhov kev sim, nws tuaj yeem pom tias tus nqi tiag tiag ntawm xoom-shear viscosity ntawm KGM / HPMC compound kev daws yog me dua li qhov theoretical tus nqi. Qhov no tau qhia tias kev sib dhos tshiab nrog cov qauv ntom ntom tau tsim nyob rau hauv cov txheej txheem nyuaj ntawm KGM thiab HPMC. Cov kev tshawb fawb uas twb muaj lawm tau pom tias cov mannose tsis hloov pauv ntawm KGM cov saw hlau molecular tuaj yeem cuam tshuam nrog cov pab pawg hydrophobic ntawm HPMC cov saw hlau molecular los tsim ib qho kev sib txuas tsis muaj zog hauv cheeb tsam hydrophobic. Nws tau kwv yees tias cov qauv sib dhos tshiab nrog cov qauv ntom ntom feem ntau yog tsim los ntawm kev sib cuam tshuam hydrophobic. Thaum KGM piv yog qis (HPMC> 50%), tus nqi tiag tiag ntawm xoom-shear viscosity ntawm KGM / HPMC system yog qis dua li qhov theoretical tus nqi, uas qhia tau hais tias ntawm cov ntsiab lus KGM qis, ntau cov molecules koom nrog cov denser tshiab. qauv. Nyob rau hauv lub tsim ntawm, lub zero-shear viscosity ntawm lub system yog ntxiv txo.

2.2 Kev soj ntsuam ntawm cov kab cheb nkhaus ntawm KGM/HPMC compound system

Los ntawm kev sib raug zoo curves ntawm modulus thiab shear strain ntawm KGM / HPMC cov kev daws teeb meem nrog ntau pawg pawg thiab sib txawv compounding ratios, nws tuaj yeem pom tias thaum lub shear strain tsawg dua 10%, G'thiab G″ntawm cov compound system yeej tsis nce nrog shear strain. Txawm li cas los xij, nws qhia tau hais tias nyob rau hauv no shear strain ntau yam, lub compound system muaj peev xwm teb rau sab nraud stimuli los ntawm kev hloov ntawm molecular saw conformation, thiab cov qauv ntawm cov compound system tsis puas. Thaum lub shear strain yog> 10%, sab nraud Nyob rau hauv qhov kev txiav txim ntawm shear quab yuam, lub disentanglement ceev ntawm molecular chains nyob rau hauv lub complex system yog ntau tshaj qhov entanglement ceev, G'thiab G″pib txo qis, thiab lub kaw lus nkag mus rau thaj tsam nonlinear viscoelastic. Yog li ntawd, nyob rau hauv lub tom ntej no dynamic zaus xeem, lub shear strain parameter raug xaiv raws li 1% rau kev xeem.

2.3 Zaus cheb nkhaus tsom ntawm KGM/HPMC compound system

Variation curves ntawm cia modulus thiab poob modulus nrog zaus rau KGM/HPMC kev daws teeb meem nrog sib txawv compounding ratios nyob rau hauv sib txawv pawg pawg. Lub modulus cia G' sawv cev rau lub zog uas tuaj yeem rov qab los tom qab ib ntus cia hauv qhov kev sim, thiab qhov poob modulus G" txhais tau hais tias lub zog xav tau rau qhov pib ntws, uas yog qhov poob tsis tuaj yeem thiab thaum kawg hloov mus rau shear tshav kub. Nws tuaj yeem pom tau tias, Raws li qhov zaus oscillation nce, qhov poob modulus G″yog ib txwm ntau dua li qhov khaws cia modulus G', qhia txog tus cwj pwm ua kua. Nyob rau hauv qhov kev xeem ntau zaus, qhov cia modulus G 'thiab qhov poob modulus G' nce nrog qhov nce ntawm oscillation zaus. Qhov no feem ntau yog vim qhov tseeb tias nrog qhov nce ntawm qhov zaus oscillation, cov ntu molecular saw ntu hauv lub cev tsis muaj sijhawm los rov qab mus rau qhov deformation nyob rau lub sijhawm luv luv Lub xeev dhau los, yog li qhia qhov tshwm sim uas ntau lub zog tuaj yeem khaws cia ( loj G') lossis yuav tsum tau ploj (G″).

Nrog rau qhov nce ntawm qhov oscillation zaus, qhov chaw cia khoom ntawm lub kaw lus poob dheev, thiab nrog qhov nce ntawm cov feem ntau thiab KGM cov ntsiab lus ntawm qhov system, qhov zaus taw tes ntawm qhov poob tam sim ntawd maj mam nce. Kev poob tam sim ntawd yuav yog vim kev puas tsuaj ntawm cov qauv compact tsim los ntawm hydrophobic koom haum ntawm KGM thiab HPMC nyob rau hauv lub system los ntawm sab nraud shearing. Ntxiv mus, qhov nce ntawm cov txheej txheem pawg feem thiab cov ntsiab lus KGM muaj txiaj ntsig zoo rau kev tswj hwm tus qauv tuab, thiab nce cov qauv sab nraud uas rhuav tshem cov qauv.

2.4 Temperature scanning curve analysis of KGM/HPMC composite system

Los ntawm cov nkhaus ntawm qhov chaw cia khoom thiab poob modulus ntawm KGM / HPMC cov kev daws teeb meem nrog cov zauv feem sib txawv thiab cov sib xyaw sib txawv sib txawv, nws tuaj yeem pom tau tias thaum qhov loj ntawm qhov system yog 0.50%, G'thiab G″ntawm cov tshuaj HPMC tsis tshua hloov nrog kub. , thiab G″> G', lub viscosity ntawm lub system dominates; Thaum qhov loj feem ntau nce, G'ntawm HPMC kev daws thawj zaug tseem tsis hloov pauv thiab tom qab ntawd nce siab, thiab G'thiab G″sib tshuam nyob ib ncig ntawm 70°C (Qhov kev sib tshuam taw tes kub yog qhov taw tes gel), thiab lub kaw lus tsim cov gel nyob rau lub sijhawm no, yog li qhia tias HPMC yog ib qho thermally induced gel. Rau cov tshuaj KGM, thaum qhov loj feem ntawm qhov system yog 0.50% thiab 0.75%, G'thiab G ntawm lub kaw lus "qhia qhov kev poob qis; Thaum qhov loj feem ntau nce, G' thiab G" ntawm KGM cov tshuaj ua ntej txo qis thiab tom qab ntawd nce ntxiv, uas qhia tau hais tias KGM cov tshuaj muaj cov khoom zoo li gel ntawm cov feem loj loj thiab qhov kub thiab txias.

Nrog rau qhov kub thiab txias, G'thiab G″ntawm KGM / HPMC complex system ua ntej txo qis thiab tom qab ntawd nce ntau, thiab G'thiab G″tshwm kev sib tshuam cov ntsiab lus, thiab lub kaw lus tsim ib gel. Thaum HPMC molecules nyob rau ntawm qhov kub thiab txias, hydrogen bonding tshwm sim ntawm cov hydrophilic pawg ntawm cov molecular saw thiab dej molecules, thiab thaum kub nce, cov ntaub ntawv kub ua rau cov hydrogen bonds tsim ntawm HPMC thiab dej molecules, uas ua rau tsim HPMC macromolecular. chains. Cov pab pawg hydrophobic nyob rau saum npoo raug nthuav tawm, lub koom haum hydrophobic tshwm sim, thiab cov thermotropic gel yog tsim. Rau qhov qis pawg feem ntau, ntau KGM cov ntsiab lus tuaj yeem tsim cov gel; rau cov kab ke loj loj, ntau cov ntsiab lus HPMC tuaj yeem tsim cov gel. Hauv qhov qis qis qis (0.50%), lub xub ntiag ntawm KGM molecules txo qhov tshwm sim ntawm kev tsim hydrogen bonds ntawm HPMC molecules, yog li ua rau muaj kev cuam tshuam ntawm pawg hydrophobic hauv HPMC molecules, uas yog qhov tsim nyog rau kev tsim cov thermotropic gels. Nyob rau hauv lub siab loj feem system, yog hais tias cov ntsiab lus ntawm KGM yog siab dhau lawm, lub viscosity ntawm lub system yog siab, uas yog tsis conducive rau lub hydrophobic koom haum ntawm HPMC thiab KGM molecules, uas yog tsis conducive rau tsim ntawm thermogenic gel.

3. Cov lus xaus

Nyob rau hauv daim ntawv no, tus cwj pwm rheological ntawm lub compound system ntawm KGM thiab HPMC yog kawm. Cov txiaj ntsig tau pom tias cov kab ke sib txuas ntawm KGM / HPMC yog cov kua dej uas tsis yog-Newtonian, thiab cov kua hom kev sib xyaw ntawm KGM / HPMC feem ntau yog txiav txim los ntawm KGM. Ua kom cov kab ke loj feem ntau thiab KGM cov ntsiab lus ob qho tib si txo qhov fluidity ntawm cov tshuaj tov thiab nce nws cov viscosity. Hauv lub xeev sol, cov saw hlau molecular ntawm KGM thiab HPMC tsim cov qauv denser los ntawm kev sib cuam tshuam hydrophobic. Cov qauv hauv lub cev raug rhuav tshem los ntawm sab nraud shearing, uas ua rau muaj kev poob qis hauv qhov chaw cia khoom ntawm qhov system. Qhov nce ntawm cov txheej txheem pawg pawg feem thiab cov ntsiab lus KGM tau txais txiaj ntsig zoo rau kev tswj hwm qhov chaw ruaj khov thiab nce sab nraud kom rhuav tshem cov qauv. Rau qhov qis pawg feem ntau, ntau KGM cov ntsiab lus yog qhov tsim nyog rau kev tsim cov gel; rau lub siab loj feem ntau, ntau cov ntsiab lus HPMC yog qhov tsim nyog rau kev tsim cov gel.