HPMC yog ib tug semi-synthetic polymer muab los ntawm cellulose. Vim nws zoo heev thickening, stabilizing thiab zaj duab xis-forming zog, nws yog dav siv nyob rau hauv tshuaj, zaub mov, tshuaj pleev ib ce thiab lwm yam lag luam. Kawm txog nws tus cwj pwm viscosity yog qhov tseem ceeb rau kev txhim kho nws cov kev ua tau zoo hauv ntau daim ntawv thov.
1. Kev ntsuas viscosity:
Rotational Viscometer: Ib qho viscometer rotational ntsuas lub torque yuav tsum tau tig lub ntxaiv ntawm qhov ceev tsis tu ncua thaum muab tso rau hauv cov qauv. Los ntawm kev sib txawv ntawm geometry thiab rotational ceev ntawm spindle, viscosity ntawm ntau shear tus nqi tuaj yeem txiav txim siab. Txoj kev no ua rau tus cwj pwm ntawm HPMC viscosity nyob rau hauv cov xwm txheej sib txawv.
Capillary Viscometer: Lub capillary viscometer ntsuas qhov ntws ntawm cov kua los ntawm lub raj capillary nyob rau hauv lub zog ntawm lub ntiajteb txawj nqus lossis siab. Cov tshuaj HPMC raug yuam los ntawm lub raj capillary thiab cov viscosity yog xam raws li tus nqi ntws thiab siab poob. Txoj kev no tuaj yeem siv los kawm HPMC viscosity ntawm qis shear tus nqi.
2.Rheological ntsuas:
Dynamic Shear Rheometry (DSR): DSR ntsuas cov lus teb ntawm cov khoom rau dynamic shear deformation. HPMC cov qauv tau raug rau oscillatory shear stress thiab cov txiaj ntsig tau raug ntsuas. Tus cwj pwm viscoelastic ntawm HPMC cov kev daws teeb meem tuaj yeem raug txheeb xyuas los ntawm kev txheeb xyuas qhov nyuaj viscosity (η*) nrog rau cov khoom siv khaws cia (G') thiab poob modulus (G").
Kev kuaj ntshav thiab rov qab: Cov kev ntsuam xyuas no suav nrog HPMC cov qauv rau kev ntxhov siab tsis tu ncua lossis kev nyuaj siab rau lub sijhawm ntev (theem creep) thiab tom qab ntawd saib xyuas kev rov qab los tom qab kev ntxhov siab lossis kev ntxhov siab. Creep thiab rov qab tus cwj pwm muab kev pom rau cov viscoelastic zog ntawm HPMC, nrog rau nws cov deformation thiab rov qab muaj peev xwm.
3. Kev Tshawb Fawb Txog Kev Tshawb Fawb thiab qhov kub thiab txias:
Kev Ntsuas Kev Ntsuas: Kev ntsuas viscosity tau ua dhau los ntawm HPMC cov ntsiab lus los kawm txog kev sib raug zoo ntawm viscosity thiab polymer concentration. Qhov no yuav pab kom nkag siab txog qhov thickening efficiency ntawm cov polymer thiab nws cov concentration-dependent tus cwj pwm.
Kev ntsuas kub: Kev ntsuas viscosity yog ua ntawm qhov kub sib txawv los kawm txog qhov kub ntawm HPMC viscosity. Kev nkag siab txog qhov kub thiab txias yog qhov tseem ceeb rau cov ntawv thov uas HPMCs muaj kev hloov pauv kub, xws li cov tshuaj tsim tshuaj.
4. Molecular hnyav tsom xam:
Size Exclusion Chromatography (SEC): SEC cais cov polymer molecules raws li lawv qhov loj me hauv kev daws. Los ntawm kev txheeb xyuas qhov elution profile, qhov hnyav molecular faib ntawm HPMC tus qauv tuaj yeem txiav txim siab. Kev nkag siab txog kev sib raug zoo ntawm molecular hnyav thiab viscosity yog qhov tseem ceeb rau kev kwv yees tus cwj pwm rheological ntawm HPMC.
5. Qauv thiab Simulation:
Cov qauv theoretical: Ntau cov qauv theoretical, xws li Carreau-Yasuda qauv, Cross qauv lossis lub hwj chim txoj cai qauv, tuaj yeem siv los piav qhia txog tus cwj pwm viscosity ntawm HPMC nyob rau hauv cov txheej txheem sib txawv. Cov qauv no muab cov kev ntsuas xws li shear rate, concentration, thiab molecular hnyav kom raug kwv yees viscosity.
Computational Simulations: Computational Fluid Dynamics (CFD) simulations muab kev pom rau tus cwj pwm ntws ntawm HPMC cov kev daws teeb meem hauv cov geometries nyuaj. Los ntawm kev daws cov lej tswj hwm kev sib npaug ntawm cov kua dej ntws, CFD simulations tuaj yeem kwv yees cov viscosity faib thiab ntws cov qauv hauv cov xwm txheej sib txawv.
6. Kev tshawb fawb hauv tsev thiab hauv vitro:
Kev ntsuas hauv-situ: Cov txheej txheem hauv-situ koom nrog kev kawm txog lub sijhawm hloov pauv viscosity hauv ib puag ncig tshwj xeeb lossis daim ntawv thov. Piv txwv li, nyob rau hauv cov tshuaj formulations, nyob rau hauv qhov chaw ntsuas yuav saib xyuas viscosity hloov thaum lub ntsiav tshuaj disintegration los yog tshuaj pleev gel daim ntawv thov.
Kev kuaj hauv vitro: Kev kuaj hauv vitro simulates lub cev nqaij daim tawv los ntsuas tus cwj pwm viscosity ntawm HPMC-based formulations npaj rau qhov ncauj, qhov muag, lossis tshuaj pleev ib ce. Cov kev ntsuam xyuas no muab cov ntaub ntawv tseem ceeb ntawm kev ua tau zoo thiab kev ruaj ntseg ntawm kev tsim nyob rau hauv cov xwm txheej lom lom.
7.Advanced technology:
Microrheology: Cov txheej txheem microrheology, xws li dynamic light scattering (DLS) los yog particle tracking microrheology (PTM), tso cai rau kev soj ntsuam cov viscoelastic zog ntawm cov kua dej complex ntawm microscopic scale. Cov tswv yim no tuaj yeem muab kev nkag siab txog tus cwj pwm ntawm HPMC ntawm qib molecular, ntxiv rau kev ntsuas macroscopic rheological.
Nuclear Magnetic Resonance (NMR) Spectroscopy: NMR spectroscopy tuaj yeem siv los kawm txog cov molecular dynamics thiab kev cuam tshuam ntawm HPMC hauv kev daws teeb meem. Los ntawm kev saib xyuas cov tshuaj hloov pauv thiab lub sijhawm so, NMR muab cov ntaub ntawv tseem ceeb ntawm HPMC kev hloov pauv thiab kev sib cuam tshuam ntawm polymer-solvent uas cuam tshuam rau viscosity.
Kawm txog tus cwj pwm viscosity ntawm HPMC yuav tsum muaj ntau txoj hauv kev, suav nrog cov txheej txheem kev sim, kev ua qauv, thiab cov txheej txheem analytical siab. Los ntawm kev siv kev sib xyaw ua ke ntawm viscometry, rheometry, molecular tsom xam, qauv, thiab cov txheej txheem siab heev, cov kws tshawb fawb tuaj yeem nkag siab tag nrho ntawm cov khoom rheological ntawm HPMC thiab txhim kho nws cov kev ua tau zoo hauv ntau yam kev siv.
Post lub sij hawm: Feb-29-2024