Pharmaceutical Grade Hydroxypropyl Methylcellulose (HPMC) yog ib qho khoom siv tshuaj, siv dav hauv kev lag luam kws tshuaj. Nws yog semi-synthetic, inert, dej-soluble cellulose ether, uas yog chemically hloov los ntawm ntuj cellulose. HPMC muaj kev ua yeeb yaj kiab zoo, thickening, adhesion, ncua kev kawm ntawv thiab cov khoom tiv thaiv, yog li nws muaj txiaj ntsig tseem ceeb hauv kev npaj tshuaj.
1. Cov khoom tseem ceeb ntawm HPMC
HPMC yog tsim los ntawm kev hloov cov hydroxyl ib feem ntawm cellulose nrog hydroxypropyl thiab methoxy pawg. Nws cov qauv molecular muaj ob qhov hloov pauv, hydroxypropyl thiab methyl, yog li nws muaj npe hu ua hydroxypropyl methylcellulose. HPMC muaj zoo solubility nyob rau hauv dej, thiab tom qab dissolution, nws tsim ib tug pob tshab viscous tov. Thaum lub concentration nce, lub viscosity kuj nce. Tsis tas li ntawd, HPMC muaj qhov zoo thermal stability thiab tshuaj lom neeg ruaj khov, thiab muaj kev ua siab ntev rau cov kua qaub, alkali thiab ntsev.
2. Kev thov ntawm HPMC hauv cov tshuaj
HPMC tau siv dav hauv kev lag luam kws tshuaj, feem ntau hauv cov hauv qab no:
ib. Tablet txheej
HPMC, raws li cov khoom siv txheej txheej rau cov ntsiav tshuaj, tuaj yeem npog qhov tsis zoo ntawm cov tshuaj, txhim kho cov tsos mob ntawm cov tshuaj, thiab muaj cov dej noo-pov thawj thiab tiv thaiv oxidation. Tsis tas li ntawd, nws muaj peev xwm ncua lub sij hawm tso tawm ntawm cov tshuaj nyob rau hauv lub plab zom mov, yog li ua tiav los yog tswj kev tso tawm los.
b. Thickeners thiab binders
Thaum npaj suspensions, emulsions, capsules thiab lwm yam kev npaj, HPMC, raws li ib tug thickener thiab binder, yuav txhim khu kev ruaj ntseg thiab uniformity ntawm kev npaj. Tib lub sijhawm, HPMC tseem tuaj yeem txhim kho cov tawv tawv thiab lub zog ntawm cov ntsiav tshuaj kom ntseeg tau tias cov tshuaj tsis yooj yim tawg thaum tsim khoom thiab kev thauj mus los.
c. Tswj tau thiab txhawb nqa-tso npaj
HPMC feem ntau yog siv rau hauv kev tswj-tso tawm thiab kev npaj tso tawm vim tias cov gel txheej uas nws tsim tuaj yeem tiv thaiv cov dej nkag mus rau hauv cov ntsiav tshuaj, kom qhov kev sib cais thiab tso tawm ntawm cov tshuaj yog tswj tau zoo. Los ntawm kev kho cov viscosity thiab ntau npaum li cas ntawm HPMC, qhov tso tawm ntawm cov tshuaj tuaj yeem raug tswj kom raug, lub sijhawm ua haujlwm ntawm cov tshuaj tuaj yeem ua kom ntev, thiab qhov zaus ntawm cov tshuaj tuaj yeem txo.
d. Raws li ib tug muab tub lim
Hauv kev npaj tshuaj ntsiav, HPMC tuaj yeem siv los ua cov khoom siv los sau cov tshuaj ntsiav. Piv nrog rau cov tshuaj ntsiav tshuaj gelatin, HPMC capsules muaj qhov zoo ntawm kev cog qoob loo thiab tsis muaj cov khoom xyaw tsiaj, yog li lawv tsim nyog rau cov neeg tsis noj nqaij thiab cov neeg mob uas muaj kev cai dab qhuas.
3. Kev nyab xeeb ntawm HPMC
Raws li ib qho tshuaj excipient, HPMC muaj biocompatibility zoo thiab kev nyab xeeb. Nws tsis yog decomposed los ntawm digestive enzymes nyob rau hauv tib neeg lub cev thiab yog tsuas yog tawm ntawm lub cev los ntawm txoj hnyuv, yog li nws tsis koom nyob rau hauv cov tshuaj metabolism hauv cov txheej txheem thiab tsis tsim tshuaj lom phiv. HPMC tau siv dav hauv ntau qhov ncauj, tshuaj pleev ib ce thiab txhaj tshuaj thiab tau lees paub los ntawm pharmacopoeias thoob ntiaj teb.
4. Kev lag luam zeem muag
Nrog rau kev txhim kho txuas ntxiv ntawm kev lag luam tshuaj, cov kev xav tau ntawm cov tshuaj zoo thiab kev nyab xeeb kuj nce ntxiv. Vim nws qhov tshwj xeeb lub cev thiab tshuaj lom neeg thiab kev nyab xeeb zoo, HPMC muaj cov ntawv thov dav dav hauv kev npaj tshuaj tshiab. Tshwj xeeb tshaj yog nyob rau hauv kev tswj-tso tawm thiab sustained-tso npaj, tshuaj lom neeg thiab tshuaj rau cov neeg tshwj xeeb (xws li cov neeg tsis noj nqaij), qhov kev thov rau HPMC yuav loj hlob ntxiv.
Raws li cov khoom siv tshuaj ntau yam, cov tshuaj qib hydroxypropyl methylcellulose tau ua lub luag haujlwm tseem ceeb hauv kev lag luam kws tshuaj thiab yuav txuas ntxiv siv dav thiab tsim nyob rau yav tom ntej.
Post lub sij hawm: Aug-06-2024