Pharmaceutical qib HPMC
Pharmaceutical qib HPMC Hydroxypropyl methylcellulose yog dawb los yog milky dawb, tsis muaj ntxhiab, tsis qab, fibrous hmoov los yog granule, poob ntawm qhuav tsis tshaj 10%, soluble nyob rau hauv dej txias tab sis tsis kub dej, maj mam nyob rau hauv dej kub o, peptization, thiab ua ib tug viscous colloidal tov, uas dhau los ua ib qho kev daws thaum txias, thiab dhau los ua gel thaum rhuab. HPMC yog insoluble hauv ethanol, chloroform thiab ether. Nws yog soluble hauv cov kuab tshuaj sib xyaw ntawm methanol thiab methyl chloride. Nws kuj yog soluble hauv cov kuab tshuaj sib xyaw ntawm acetone, methyl chloride thiab isopropanol thiab qee cov kuab tshuaj organic. Nws cov tshuaj aqueous tuaj yeem tiv taus ntsev (nws cov tshuaj colloidal tsis raug puas tsuaj los ntawm ntsev), thiab pH ntawm 1% aqueous tov yog 6-8. Cov mis mos molecular ntawm HPMC yog C8H15O8-(C10H18O6) -C815O, thiab cov txheeb ze molecular loj yog li 86,000.
Tshuaj Specification
| Pharmaceutical HPMC Specification | HPMC 60 E( 2910 ib) | HWM 65 F(2906 ib) | HPMC 75 K( 2208) |
| Gel kub (℃) | 58-64 : kuv | 62-68 : kuv | 70-90 : kuv |
| Methoxy (WT%) | 28.0-30.0 Nws | 27.0-30.0 Nws | 19.0-24.0 Nws |
| Hydroxypropoxy (WT%) | 7.0-12.0 Nws | 4.0-7.5 | 4.0-12.0 Nws |
| Viscosity (cps, 2% daws) | 3, 5, 6, 15, 50, 100, 400,4000, 10000, 40000, 60000,100000,150000,200000 | ||
Khoom Qib:
| Pharmaceutical HPMC Specification | HPMC 60 E( 2910 ib) | HWM 65 F(2906 ib) | HPMC 75 K( 2208) |
| Gel kub (℃) | 58-64 : kuv | 62-68 : kuv | 70-90 : kuv |
| Methoxy (WT%) | 28.0-30.0 Nws | 27.0-30.0 Nws | 19.0-24.0 Nws |
| Hydroxypropoxy (WT%) | 7.0-12.0 Nws | 4.0-7.5 | 4.0-12.0 Nws |
| Viscosity (cps, 2% daws) | 3, 5, 6, 15, 50, 100, 400,4000, 10000, 40000, 60000,100000,150000,200000 | ||
Daim ntawv thov
| Pharma Excipients Application | Pharmaceutical Qib HPMC | Noj |
| Tej Laxative | 75K4000,75K100000 | 3-30% |
| Cream, Gels | 60 E4000,75K4000 | 1-5% |
| Kev npaj kho qhov muag | 60 E4000 | 01.-0.5% |
| Kev npaj kho qhov muag | 60 E4000 | 0.1-0.5% |
| Suspending Agent | 60 E4000, 75K4000 | 1-2% |
| Antacids | 60 E4000, 75K4000 | 1-2% |
| Tablets Binder | 60 E5, 60 E15 | 0.5-5% |
| Convention ntub Granulation | 60 E5, 60 E15 | 2-6% |
| Ntsiav tshuaj ntsiav tshuaj | 60 E5, 60 E15 | 0.5-5% |
| Tswj Tso Tawm Matrix | 75K100000, 75K15000 | 20-55% |
Nta thiab Cov txiaj ntsig:
HPMC muaj dej solubility zoo heev hauv dej txias. Nws tuaj yeem yaj mus rau hauv cov tshuaj pob tshab nrog me ntsis nplawm hauv dej txias. Ntawm qhov tsis sib xws, nws yog qhov yooj yim insoluble hauv dej kub siab tshaj 60 ℃ thiab tuaj yeem o tuaj. Nws yog non-ionic cellulose ether. Nws cov tshuaj tsis muaj ionic nqi, tsis cuam tshuam nrog hlau ntsev los yog ionic organic tebchaw, thiab tsis hnov mob nrog lwm cov ntaub ntawv raw thaum lub sij hawm npaj; nws muaj zog los tiv thaiv rhiab heev, thiab raws li qib ntawm kev hloov pauv hauv cov qauv molecular nce, nws muaj zog tiv thaiv kev ua xua thiab ruaj khov dua; Nws tseem yog metabolically inert. Raws li ib tug kws tshuaj excipient, nws tsis yog metabolized los yog absorbed. Yog li ntawd, nws tsis muab cua sov hauv cov tshuaj thiab khoom noj. Nws yog cov calories tsawg, tsis muaj ntsev, thiab tsis muaj ntsev-dawb rau cov ntshav qab zib. Cov tshuaj tsis haum thiab cov khoom noj muaj qhov tshwj xeeb siv tau; Nws yog qhov ruaj khov rau cov kua qaub thiab alkalis, tab sis yog tias PH tus nqi siab tshaj 2 ~ 11 thiab cuam tshuam los ntawm qhov kub thiab txias dua lossis muaj lub sijhawm cia ntev dua, nws cov viscosity yuav txo; nws cov tshuaj aqueous tuaj yeem muab cov dej num hauv qhov chaw, qhia qhov nro nruab nrab ntawm qhov nro thiab qhov cuam tshuam ntawm qhov nro; nws muaj emulsification zoo nyob rau hauv ob-theem systems, yuav siv tau raws li ib tug zoo stabilizer thiab tiv thaiv colloid; nws cov tshuaj aqueous muaj cov yeeb yaj kiab zoo heev, thiab yog cov ntsiav tshuaj thiab ntsiav tshuaj Cov khoom siv zoo. Cov zaj duab xis txheej tsim los ntawm nws muaj qhov zoo ntawm cov xim tsis muaj xim thiab toughness. Ntxiv glycerin tuaj yeem txhim kho nws cov yas.
Ntim
Cov txheej txheem ntim khoom yog 25kg / Fiber nruas
20'FCL: 9 tuj nrog palletized; 10 tuj unpalletized.
40'FCL: 18 tuj nrog palletized; 20 tuj unpalletized.
Cia:
Khaws cia rau hauv qhov chaw txias, qhuav hauv qab 30 ° C thiab tiv thaiv cov av noo thiab nias, vim tias cov khoom yog thermoplastic, lub sijhawm cia yuav tsum tsis pub tshaj 36 lub hlis.
Cov ntawv ceeb toom kev nyab xeeb:
Cov ntaub ntawv saum toj no yog ua raws li peb txoj kev paub, tab sis tsis txhob daws cov neeg siv khoom ua tib zoo xyuas tag nrho tam sim ntawm daim ntawv txais nyiaj. Txhawm rau kom tsis txhob muaj cov qauv sib txawv thiab cov khoom sib txawv, thov ua qhov kev sim ntau dua ua ntej siv nws.
Post lub sij hawm: Nov-26-2023