Ua Hand Sanitizer Gel siv HPMC los hloov Carbomer
Cov tshuaj ntxuav tes ntxuav tes tau dhau los ua ib yam khoom tseem ceeb hauv peb lub neej niaj hnub, tshwj xeeb tshaj yog thaum muaj tus kab mob COVID-19. Cov khoom xyaw nquag hauv cov tshuaj ntxuav tes gel feem ntau yog cawv, uas muaj txiaj ntsig zoo tua kab mob thiab kab mob ntawm tes. Txawm li cas los xij, txhawm rau tsim cov tshuaj gel, tus neeg sawv cev thickening yuav tsum tau tsim kom muaj kev ruaj khov zoo li gel. Carbomer yog ib qho uas nquag siv cov tshuaj tua kab mob hauv tes gel formulations, tab sis nws tuaj yeem nyuaj rau qhov chaw thiab tau pom tus nqi nce vim muaj kev sib kis. Hauv tsab xov xwm no, peb yuav tham txog yuav ua li cas ntxuav tes ntxuav tes gel siv Hydroxypropyl Methylcellulose (HPMC) los hloov cov carbomer.
Hydroxypropyl Methylcellulose (HPMC) yog ib qho cellulose derivative uas muaj ntau yam kev siv, nrog rau cov thickener, binder, thiab emulsifier. HPMC yog cov dej-soluble polymer uas tuaj yeem ua kom cov dej-raws li cov qauv, ua rau nws yog ib qho tsim nyog rau carbomer hauv cov tshuaj ntxuav tes gel formulations. HPMC kuj tau yooj yim muaj thiab muaj txiaj ntsig zoo dua li carbomer, ua rau nws muaj txiaj ntsig zoo rau cov neeg tsim khoom.
Txhawm rau ua cov tshuaj ntxuav tes ntxuav tes siv HPMC, cov khoom xyaw thiab cov khoom siv hauv qab no xav tau:
Cov khoom xyaw:
- Isopropyl cawv (los yog ethanol)
- Hydrogen peroxide
- Glycerin
- Hydroxypropyl Methylcellulose (HPMC)
- Cov dej distilled
Khoom siv:
- Sib tov lub tais
- Stirring pas nrig los yog hluav taws xob tov khoom
- Ntsuas khob thiab diav
- pH ntsuas
- Lub thawv rau khaws cov tshuaj ntxuav tes gel
Kauj Ruam 1: Ntsuas Cov Khoom Ntsuas Ntsuas cov khoom xyaw hauv qab no:
- Isopropyl cawv (los yog ethanol): 75% ntawm qhov kawg ntim
- Hydrogen peroxide: 0.125% ntawm qhov kawg ntim
- Glycerin: 1% ntawm qhov kawg ntim
- HPMC: 0.5% ntawm qhov kawg ntim
- Distilled dej: qhov seem ntim
Piv txwv li, yog tias koj xav ua 100ml ntawm tes ntxuav tes gel, koj yuav tsum ntsuas tawm:
- Isopropyl cawv (los yog ethanol): 75 ml
- Hydrogen peroxide: 0.125 ml
- Glycerin: 1 ml
- HPMC: 0.5ml
- Distilled dej: 23.375ml
Kauj Ruam 2: Sib tov cov khoom xyaw Sib tov cov isopropyl cawv (lossis ethanol), hydrogen peroxide, thiab glycerin ua ke hauv ib lub tais sib tov. Do cov sib tov kom txog thaum nws zoo sib xyaw.
Kauj Ruam 3: Ntxiv HPMC Maj mam ntxiv cov HPMC rau qhov sib tov thaum nplawm tas li. Nws yog ib qho tseem ceeb kom ntxiv HPMC maj mam kom tsis txhob clumping. Txuas ntxiv stirring kom txog thaum HPMC yog tag nrho dispersed thiab sib tov yog du.
Kauj Ruam 4: Ntxiv dej Ntxiv dej distilled rau qhov sib tov thaum stirring tas li. Ntxiv stirring kom txog thaum lub sib tov yog zoo ua ke.
Kauj Ruam 5: Tshawb xyuas pH Tshawb xyuas pH ntawm cov khoom sib tov siv lub ntsuas pH. pH yuav tsum nyob nruab nrab ntawm 6.0 thiab 8.0. Yog tias pH tsawg dhau, ntxiv me me ntawm sodium hydroxide (NaOH) los kho cov pH.
Kauj Ruam 6: Sib tov dua Ntxiv cov sib tov dua kom paub meej tias tag nrho cov khoom xyaw ua ke.
Kauj Ruam 7: Hloov mus rau lub Thawv Hloov Hloov cov tshuaj ntxuav tes rau hauv lub thawv rau khaws cia.
Cov tshuaj ntxuav tes gel yuav tsum muaj qhov sib xws, zoo li gel uas yooj yim siv rau ntawm tes. Lub HPMC ua raws li cov thickener thiab tsim ib tug ruaj khov gel zoo li sib xws, zoo ib yam li carbomer. Cov tshuaj ntxuav tes ntxuav tes yuav tsum muaj txiaj ntsig zoo hauv kev tua cov kab mob thiab cov kab mob ntawm tes, ib yam li cov tshuaj ntxuav tes uas muag muag.
Kev tsim cov kev coj ua (GMP) yog cov txheej txheem thiab cov ntsiab lus uas ua kom muaj kev nyab xeeb thiab nyab xeeb ntawm cov khoom siv tshuaj, suav nrog cov tshuaj ntxuav tes gel. Cov txheej txheem no suav nrog ntau yam ntawm cov txheej txheem tsim khoom, suav nrog cov neeg ua haujlwm, thaj chaw, khoom siv, cov ntaub ntawv, kev tsim khoom, kev tswj kom zoo, thiab kev faib tawm.
Thaum tsim cov tshuaj ntxuav tes gel siv HPMC lossis lwm tus neeg ua kom tuab, nws yog ib qho tseem ceeb uas yuav tsum tau ua raws li GMP cov lus qhia kom paub meej qhov zoo thiab kev nyab xeeb ntawm cov khoom. Qee qhov tseem ceeb GMP cov lus qhia uas yuav tsum tau ua raws thaum tsim cov tshuaj ntxuav tes gel suav nrog:
- Cov neeg ua haujlwm: Txhua tus neeg ua haujlwm koom nrog hauv cov txheej txheem tsim khoom yuav tsum raug cob qhia kom tsim nyog thiab tsim nyog rau lawv lub luag haujlwm. Lawv kuj yuav tsum paub txog GMP cov lus qhia thiab ua raws li lawv nruj me ntsis.
- Qhov chaw: Lub chaw tsim khoom yuav tsum huv si, tu kom zoo, thiab tsim los tiv thaiv kev sib kis. Lub chaw yuav tsum tau nruab nrog qhov cua thiab teeb pom kev zoo, thiab tag nrho cov khoom siv yuav tsum raug ntsuas kom raug thiab siv tau.
- Khoom siv: Txhua yam khoom siv hauv cov txheej txheem tsim khoom yuav tsum tau ua kom huv si tsis tu ncua thiab tswj kom tsis txhob muaj kab mob. Cov cuab yeej siv kuj tseem yuav raug lees paub los xyuas kom meej tias nws ua haujlwm raug thiab ua tau zoo ib yam.
- Cov ntaub ntawv: Tag nrho cov txheej txheem tsim khoom yuav tsum tau sau tseg kom raug, suav nrog cov ntaub ntawv khaws tseg, cov txheej txheem kev ua haujlwm (SOPs), thiab cov ntaub ntawv tswj xyuas zoo. Cov ntaub ntawv yuav tsum muaj meej thiab meej kom ntseeg tau tias traceability thiab lav.
- Kev tsim khoom: Cov txheej txheem tsim khoom yuav tsum ua raws li cov txheej txheem tau hais tseg thiab raug lees paub uas ua kom zoo ib yam thiab purity ntawm cov khoom. Txhua yam khoom siv hauv kev tsim khoom yuav tsum raug txheeb xyuas kom raug, txheeb xyuas, thiab khaws cia.
- Kev Tswjhwm Zoo: Kev tswj xyuas kev ua tau zoo yuav tsum nyob hauv qhov chaw kom ntseeg tau tias cov khoom kawg ua tau raws li qhov yuav tsum tau ua. Kev tswj kom zoo yuav tsum suav nrog kev sim rau tus kheej, purity, lub zog, thiab lwm yam kev ntsuas.
- Kev faib tawm: Cov khoom tiav yuav tsum tau ntim kom zoo, sau npe, thiab khaws cia kom tsis txhob muaj kab mob thiab tswj nws txoj kev ncaj ncees. Cov txheej txheem kev faib khoom yuav tsum raug sau tseg kom raug, thiab tag nrho cov khoom xa tuaj yuav tsum tau ua raws thiab saib xyuas kom raug.
Los ntawm kev ua raws li cov lus qhia GMP no, cov tuam txhab lag luam tuaj yeem xyuas kom meej tias lawv cov khoom siv tshuaj ntxuav tes gel yog cov khoom zoo thiab muaj kev nyab xeeb rau kev siv. Cov lus qhia no tseem pab kom muaj kev sib luag thiab kev ntseeg siab hauv cov txheej txheem tsim khoom, uas yog qhov tseem ceeb rau kev ua kom tau raws li qhov xav tau ntau ntxiv rau cov tshuaj ntxuav tes gel thaum lub sijhawm COVID-19 muaj thoob qhov txhia chaw.
Hauv kev xaus, Hydroxypropyl Methylcellulose (HPMC) tuaj yeem siv los hloov cov carbomer hauv cov tshuaj ntxuav tes gel formulations. HPMC yog ib qho txiaj ntsig zoo thiab muaj peev xwm muaj lwm txoj hauv kev uas tuaj yeem muab cov khoom zoo sib xws rau cov carbomer. Thaum tsim cov tshuaj ntxuav tes gel siv HPMC, nws yog ib qho tseem ceeb uas yuav tsum ua raws li GMP cov lus qhia kom paub meej qhov zoo thiab kev nyab xeeb ntawm cov khoom. Los ntawm kev ua raws li cov lus qhia no, cov tuam txhab tsim khoom tuaj yeem tsim cov tshuaj ntxuav tes uas muaj txiaj ntsig zoo hauv kev tua cov kab mob thiab cov kab mob ntawm tes, thaum tseem ua kom muaj kev nyab xeeb ntawm cov neeg siv kawg.
Post lub sij hawm: Mar-18-2023