Hydroxypropyl methylcellulose (HPMC) yog ntau yam polymer siv nyob rau hauv ntau yam lag luam vim nws cov khoom tshwj xeeb. Thaum nws tuaj yeem siv los tsim hydrogels nyob rau hauv qee yam mob, nws tsis yog ib qho hydrogel nws tus kheej.
1. Taw qhia rau HPMC:
Hydroxypropyl methylcellulose (HPMC) yog ib tug semi-synthetic polymer muab los ntawm cellulose, ib tug natural polymer pom nyob rau hauv cov nroj tsuag 'cell phab ntsa. Nws yog synthesized los ntawm kev kho cellulose nrog alkali thiab reacting nws nrog propylene oxide thiab methyl chloride. Qhov tshwm sim polymer nthuav tawm ntau yam khoom uas ua rau nws muaj txiaj ntsig hauv ntau yam kev lag luam, suav nrog tshuaj, khoom noj, tshuaj pleev ib ce, thiab kev tsim kho.
2. Cov khoom ntawm HPMC:
HPMC muaj ntau yam zoo:
ib. Dej Solubility:
HPMC yog soluble nyob rau hauv dej, tsim viscous daws. Cov cuab yeej no muaj txiaj ntsig tshwj xeeb hauv cov tshuaj, qhov twg nws tuaj yeem siv los tsim kev ncua, emulsions, thiab tswj-tso tshuaj formulations.
b. Film-Forming Muaj peev xwm:
HPMC tuaj yeem tsim cov yeeb yaj kiab hloov tau yooj yim thiab pob tshab thaum nrum los ntawm nws cov kev daws teeb meem aqueous. Cov yeeb yaj kiab no pom cov ntawv thov hauv txheej rau cov ntsiav tshuaj, tshuaj ntsiav, thiab cov yeeb yaj kiab hauv qhov ncauj.
c. Rheology Modifier:
HPMC ua raws li lub thickener thiab rheology hloov kho nyob rau hauv aqueous daws. Nws cov viscosity tuaj yeem raug kho los ntawm kev hloov kho yam xws li qhov hnyav molecular thiab qib hloov pauv.
d. Biocompatibility:
HPMC yog biocompatible thiab non-toxic, ua rau nws haum rau siv nyob rau hauv tshuaj, tshuaj pleev ib ce, thiab khoom noj khoom haus.
3. Kev siv ntawm HPMC:
HPMC pom cov ntawv thov thoob plaws hauv ntau qhov kev lag luam:
ib. Pharmaceuticals:
Nyob rau hauv cov tshuaj formulations, HPMC yog siv los ua ib tug binder, disintegrant, film-coating agent, thiab sustained-release matrix qub. Nws txhim kho cov ntsiav tshuaj kev ncaj ncees, tswj cov tshuaj tso tawm kinetics, thiab txhim kho kev ua raws li tus neeg mob.
b. Kev lag luam zaub mov:
Hauv kev lag luam khoom noj khoom haus, HPMC tau ua haujlwm ua cov thickener, emulsifier, stabilizer, thiab gelling agent. Nws pab txhawb kev ntxhib los mos, viscosity, thiab ruaj khov ntawm cov khoom noj xws li kua ntses, hnav khaub ncaws, thiab khoom qab zib.
c. Tshuaj pleev ib ce:
HPMC yog siv rau hauv cov tshuaj pleev ib ce thiab cov khoom tu tus kheej ua cov thickener, tshem tawm tus neeg sawv cev, zaj duab xis qub, thiab emulsifier. Nws imparts xav tau rheological zog rau cream, lotions, thiab gels thaum txhim kho lawv stability thiab sensory cwj pwm.
d. Kev tsim kho:
Hauv kev tsim kho kev lag luam, HPMC yog siv rau hauv cov ntaub ntawv cementitious ua tus neeg saib xyuas dej, ua kom muaj peev xwm ua haujlwm tau zoo, thiab tus neeg ua kom tuab. Nws txhim kho mortar thiab plaster yam ntxwv, xws li adhesion, cohesion, thiab sag kuj.
4. Hydrogel Tsim nrog HPMC:
Thaum HPMC nws tus kheej tsis yog hydrogel, nws tuaj yeem koom nrog hydrogel tsim nyob rau hauv cov xwm txheej tsim nyog. Hydrogel yog ib lub network ntawm cov saw hlau polymer uas muaj peev xwm nqus tau thiab khaws cov dej ntau. Kev tsim ntawm HPMC hydrogels feem ntau cuam tshuam nrog kev sib txuas ntawm cov saw hlau polymer los tsim kom muaj peb-dimensional network muaj peev xwm nqus dej.
ib. Crosslinking Agents:
Crosslinking agents xws li glutaraldehyde, genipin, los yog lub cev txoj kev xws li khov-thaw cycles yuav ua hauj lwm rau crosslink HPMC chains. Qhov crosslinking no ua rau muaj kev tsim cov hydrogel network hauv HPMC matrix.
b. Tus cwj pwm o:
Cov khoom siv hydrogel ntawm HPMC tuaj yeem hloov kho los ntawm kev hloov kho yam xws li qib ntawm kev hloov pauv, qhov hnyav molecular, thiab kev sib txuas ceev. Cov qib siab ntawm kev hloov pauv thiab qhov hnyav molecular feem ntau ua rau muaj zog hydrogel o muaj peev xwm.
c. Kev siv ntawm HPMC Hydrogels:
HPMC hydrogels pom cov ntawv thov hauv kev xa tshuaj, kho qhov txhab, cov ntaub so ntswg engineering, thiab cov tshuaj tiv thaiv. Lawv biocompatibility, tunable zog, thiab muaj peev xwm khaws dej ua rau lawv haum rau ntau yam kev siv biomedical.
HPMC yog cov khoom siv ntau yam polymer nrog ntau yam kev siv thoob plaws cov tshuaj, khoom noj, tshuaj pleev ib ce, thiab kev tsim kho kev lag luam. Thaum tsis yog ib qho hydrogel, nws tuaj yeem koom nrog hauv hydrogel tsim los ntawm kev sib txuas ntawm nws cov saw hlau polymer. Cov txiaj ntsig HPMC hydrogels nthuav tawm cov khoom xws li kev nqus dej thiab khaws cia, ua rau lawv muaj txiaj ntsig hauv kev siv biomedical. Raws li kev tshawb fawb txuas ntxiv tshawb nrhiav kev siv tshiab thiab cov qauv ntawm HPMC, nws qhov tseem ceeb hauv ntau qhov kev lag luam yuav tsum tau nthuav dav ntxiv.
Post lub sij hawm: Mar-06-2024