Hypromellose yog hydrophilic, non-ionic polymer uas yog siv nyob rau hauv ntau yam tshuaj thiab kev kho mob daim ntawv thov, xws li raws li ib tug lubricant thiab viscosity tus neeg saib xyuas nyob rau hauv lub qhov muag tee, raws li ib tug txheej txheej nyob rau hauv cov ntsiav tshuaj thiab tsiav tshuaj, thiab raws li ib tug sustained-tso tawm tus neeg saib xyuas nyob rau hauv cov tshuaj. kev xa khoom. Cov txheej txheem ntawm kev txiav txim ntawm hypromellose muaj feem xyuam rau nws cov khoom tshwj xeeb physicochemical, nrog rau nws cov dej tuav muaj peev xwm thiab nws muaj peev xwm tsim cov gels nyob rau hauv lub xub ntiag ntawm dej.
- Lubrication: Nyob rau hauv cov ntaub ntawv ntawm hypromellose qhov muag tee, lub ntsiab mechanism ntawm kev txiav txim yog lubrication. Thaum siv rau ntawm lub qhov muag, hypromellose tsim ib zaj duab xis nyias uas yuav pab txo qis kev sib txhuam ntawm daim tawv muag thiab lub cornea, yog li txo cov dryness, redness, thiab irritation. Cov nyhuv lubricating no yog vim muaj dej-tuav muaj peev xwm ntawm hypromellose, uas tso cai rau nws nqus thiab khaws cov dej noo los ntawm cov kua muag zaj duab xis, thiab nws muaj peev xwm kis tau tusyees saum npoo ntawm lub qhov muag.
- Viscosity: Hypromellose kuj tseem tuaj yeem ua kom cov viscosity ntawm cov kev daws teeb meem, uas tuaj yeem txhim kho lawv cov tuav ntawm lub qhov muag thiab ua rau lawv lub sijhawm sib cuag nrog lub qhov muag. Cov nyhuv no yog qhov tseem ceeb tshwj xeeb tshaj yog nyob rau hauv cov ntaub ntawv ntawm qhov muag tee, vim nws tuaj yeem pab txhim kho kev kho mob ntawm cov tshuaj.
- Txheej: Hypromellose feem ntau yog siv los ua txheej txheej hauv cov ntsiav tshuaj thiab tshuaj ntsiav. Hauv daim ntawv thov no, nws tsim cov txheej tiv thaiv ib puag ncig cov tshuaj uas tuaj yeem pab tswj tus nqi ntawm cov tshuaj tso tawm thiab tiv thaiv cov tshuaj los ntawm degradation hauv plab lossis hnyuv. Lub mechanism ntawm kev txiav txim ntawm hypromellose nyob rau hauv cov ntsiab lus no muaj feem xyuam rau nws lub peev xwm los tsim ib tug barrier ntawm cov tshuaj thiab ib puag ncig ib puag ncig, uas yuav pab tau txhim kho stability thiab bioavailability ntawm cov tshuaj.
- Sustained Release: Hypromellose kuj tseem siv tau los ua tus neeg saib xyuas kev tso tawm hauv kev xa tshuaj. Hauv daim ntawv thov no, nws yog siv los tsim cov gel-zoo li matrix uas tuaj yeem tswj kev tso tawm ntawm cov tshuaj nyob rau lub sijhawm ntev. Cov txheej txheem ntawm kev ua ntawm hypromellose nyob rau hauv cov ntsiab lus no muaj feem xyuam rau nws lub peev xwm los tsim ib lub network ntawm hydrogen bonds uas tuaj yeem ntes cov tshuaj molecules thiab tswj lawv tso tawm.
hypromellose mechanism ntawm kev txiav txim ntawm hypromellose muaj feem xyuam rau nws cov cim physicochemical zog, uas muaj xws li nws cov dej tuav muaj peev xwm, nws muaj peev xwm tsim gels nyob rau hauv lub xub ntiag ntawm dej, thiab nws muaj peev xwm ua rau kom lub viscosity ntawm kev daws. Cov khoom no ua rau nws muaj ntau yam thiab dav siv polymer hauv kev lag luam tshuaj thiab kev kho mob, tshwj xeeb tshaj yog nyob rau hauv kev tsim cov tshuaj tee, ntsiav tshuaj, tshuaj ntsiav, thiab tshuaj xa cov tshuab.
Post lub sij hawm: Mar-04-2023