Hypromellose Excipient | Kev siv, Cov neeg siv khoom, thiab Specifications

Hypromellose, tseem hu ua hydroxypropyl methylcellulose (HPMC), yog ib qho khoom siv ntau yam uas feem ntau siv hauv tshuaj, tshuaj pleev ib ce, khoom noj khoom haus, thiab ntau yam kev siv hauv kev lag luam. Nov yog cov ntsiab lus ntawm hypromellose excipient, suav nrog nws cov kev siv, cov neeg muag khoom, thiab cov lus qhia tshwj xeeb:

Kev siv:

1. Pharmaceuticals: Hypromellose yog dav siv los ua cov khoom siv tshuaj hauv qhov ncauj ntau npaum li cov ntsiav tshuaj, tshuaj ntsiav, thiab granules. Nws ua hauj lwm raws li ib tug binder, disintegrant, thickener, thiab film-forming tus neeg sawv cev, pab txhawb rau lub cev thiab txhua yam khoom ntawm cov ntaub ntawv ntau npaum.
2. Ophthalmic Solutions: Nyob rau hauv ophthalmic formulations, hypromellose yog siv los ua ib tug lubricant thiab viscosity-txhim kho tus neeg sawv cev nyob rau hauv lub qhov muag tee thiab tshuaj pleev los txhim kho ocular hydration thiab ntev lub sij hawm nyob rau hauv tshuaj nyob rau ntawm lub ocular nto.
3. Kev npaj tshuaj pleev xim: Hypromellose tau muab tso rau hauv cov tshuaj pleev ib ce xws li cream, gels, thiab tshuaj pleev ib ce ua tus neeg sawv cev thickening, emulsifier, thiab stabilizer los txhim kho cov khoom sib xws, kev sib kis, thiab txee lub neej.
4. Tswj-tso cov qauv: Hypromellose yog siv rau hauv kev tswj-tso tawm thiab tso tawm cov qauv tsim los hloov kho cov tshuaj tso tawm kinetics, muab cov tshuaj txuas ntxiv tso tawm thiab txhim kho cov neeg mob ua raws.
5. Khoom noj khoom haus: Hauv kev lag luam khoom noj khoom haus, hypromellose yog siv los ua tus neeg sawv cev thickening, stabilizer, thiab emulsifier hauv ntau yam khoom noj, nrog rau cov kua ntses, hnav khaub ncaws, khoom qab zib, thiab cov khoom ci.
6. Tshuaj pleev ib ce: Hypromellose yog muab tso rau hauv cov tshuaj pleev ib ce xws li cream, lotions, thiab pleev cov khoom raws li ib tug thickening tus neeg saib xyuas, zaj duab xis qub, thiab noo noo-retaining tus neeg saib xyuas los txhim kho cov khoom zoo nkauj thiab kev ua tau zoo.

Cov neeg muab khoom:

Hypromellose excipient yog muaj los ntawm ntau tus neeg muag khoom thoob ntiaj teb. Qee cov neeg muag khoom tseem ceeb thiab cov chaw tsim khoom muaj xws li:

1. Ashland Global Holdings Inc.: Ashland muaj ntau yam hypromellose cov khoom lag luam hauv qab lub npe Benecel® thiab Aqualon ™, ua rau kev siv tshuaj thiab kev saib xyuas tus kheej.
2. Kima Chemical Co., Ltd: Kima Chemical muab hypromellose-raws li cov khoom lag luam hauv qab lub npeKIMACELL, uas yog siv nyob rau hauv pharmaceuticals, zaub mov, thiab industrial daim ntaub ntawv.
3. Shin-Etsu Chemical Co., Ltd.: Shin-Etsu manufactures hypromellose-based khoom raws li lub npe Pharmacoat ™, pab kws tshuaj, zaub mov, thiab tshuaj pleev ib ce industries.
4. Colorcon: Colorcon muab hypromellose-raws li kws tshuaj excipients nyob rau hauv lub npe Opadry®, tsim rau ntsiav tshuaj zaj duab xis txheej thiab formulation kev loj hlob.
5. JRS Pharma: JRS Pharma muaj ntau yam khoom hypromellose raws li lub npe Vivapur®, tshwj xeeb rau kev siv tshuaj xws li ntsiav tshuaj khi, kev sib cais, thiab kev tso tawm.

Specifications:

Cov lus qhia tshwj xeeb rau hypromellose excipient tuaj yeem sib txawv nyob ntawm nws daim ntawv thov thiab kev tswj hwm. Common specifications muaj xws li:

• Viscosity: Hypromellose muaj nyob rau hauv ntau qib viscosity, feem ntau xws li qis mus rau siab viscosity, kom tau raws li cov kev xav tau tshwj xeeb.
• Particle Loj: Particle loj faib tuaj yeem cuam tshuam cov khoom ntws thiab compressibility ntawm hypromellose hmoov, cuam tshuam cov txheej txheem tsim cov ntsiav tshuaj.
• Moisture Content: Cov ntsiab lus noo noo yog qhov tseem ceeb uas tuaj yeem cuam tshuam rau kev ruaj ntseg thiab kev ua haujlwm ntawm hypromellose-based formulations.
• Purity thiab Impurities: Cov lus qhia tshwj xeeb rau purity, nrog rau kev txwv rau impurities xws li cov hlau hnyav, cov kuab tshuaj seem, thiab cov kab mob microbial, xyuas kom zoo thiab kev nyab xeeb ntawm cov khoom hypromellose rau kev siv tshuaj thiab zaub mov.
• Compatibility: Hypromellose yuav tsum tau sib xws nrog rau lwm yam excipients thiab active cov khoom xyaw nyob rau hauv lub formulation, nrog rau cov txheej txheem thiab cov khoom siv nyob rau hauv manufacturing.

Thaum muab hypromellose excipient, nws yog ib qho tseem ceeb kom tau txais daim ntawv pov thawj ntawm kev soj ntsuam (CoA) thiab cov ntaub ntawv ua raws cai los ntawm cov neeg muag khoom los xyuas kom meej tias cov khoom ua tau raws li qhov xav tau tshwj xeeb thiab cov qauv kev cai rau daim ntawv thov. Tsis tas li ntawd, kev koom tes nrog cov neeg muag khoom tsim nyog thiab ua raws li kev coj ua zoo (GMP) yog qhov tseem ceeb rau kev ua kom zoo, sib xws, thiab kev tswj hwm kev ua raws li hypromellose-based formulations.