Hydroxypropylmethylcellulose (HPMC) yog ntau yam polymer siv nyob rau hauv ntau yam kev lag luam, nrog rau kev siv tshuaj, kev tsim kho, khoom noj khoom haus, thiab tshuaj pleev ib ce. Ib qho ntawm nws cov kev siv ntau yog nyob rau hauv kev tsim cov khoom gel. Gels yog cov tshuab semisolid nrog cov khoom tshwj xeeb rheological, thiab lawv cov kev ua tau zoo tuaj yeem cuam tshuam los ntawm ntau yam, suav nrog qhov kub thiab txias.
qhia
Hydroxypropylmethylcellulose (HPMC) yog cellulose derivative synthesized los ntawm kev kho cellulose nrog propylene oxide thiab methyl chloride. Nws belongs rau tsev neeg cellulose ether thiab muaj dej-soluble thiab gelling zog. HPMC yog siv dav hauv kev lag luam tshuaj, khoom noj khoom haus, kev tsim kho thiab tshuaj pleev ib ce vim nws txoj kev ua yeeb yaj kiab zoo heev, thickening thiab gelling muaj peev xwm.
Gelation ntawm HPMC
Gelation yog cov txheej txheem los ntawm cov kua los yog cov kua hloov mus rau hauv gel, ib lub xeev ib nrab uas muaj cov kua thiab cov khoom. HPMC gels los ntawm ib tug mechanism ntawm hydration thiab peb-dimensional network tsim. Cov txheej txheem gelation yog cuam tshuam los ntawm cov khoom xws li polymer concentration, molecular hnyav thiab kub.
Kub dependence ntawm gelation
Qhov kub thiab txias ua lub luag haujlwm tseem ceeb hauv kev coj tus cwj pwm gelation ntawm HPMC. Kev sib raug zoo ntawm qhov kub thiab txias tuaj yeem yog qhov nyuaj, thiab nws yog ib qho tseem ceeb kom nkag siab tias qhov kub thiab txias cuam tshuam li cas ntawm HPMC gels. Feem ntau hais lus, gelation ntawm HPMC yog txheej txheem exothermic, txhais tau tias nws tso cua sov.
1. Txheej txheem cej luam ntawm thermal gels
Thermal gelation curves ntawm HPMC yog tus cwj pwm los ntawm qhov ntsuas kub ntawm gelation, piv txwv li qhov kub ntawm qhov kev hloov ntawm sol mus rau gel tshwm sim. Lub gelation kub yog cuam tshuam los ntawm HPMC concentration hauv cov tshuaj. Cov concentration ntau dua feem ntau ua rau muaj qhov kub thiab txias dua.
2. cuam tshuam rau viscosity
Qhov kub thiab txias cuam tshuam rau viscosity ntawm HPMC tov thiab yog li cov txheej txheem gelation. Raws li qhov kub thiab txias, qhov viscosity ntawm HPMC cov tshuaj txo qis. Qhov txo qis hauv viscosity cuam tshuam rau gel dynamics thiab kawg gel zog. Kub yuav tsum tau ua tib zoo tswj thiab saib xyuas thaum lub sij hawm tsim kom ua tiav qhov xav tau viscosity thiab gel zog.
Cov yam ntxwv cuam tshuam rau gel kub
Ntau yam cuam tshuam rau qhov kub thiab txias ntawm HPMC, thiab kev nkag siab txog cov xwm txheej no yog qhov tseem ceeb rau cov kws tsim qauv thiab cov kws tshawb fawb.
1. Polymer concentration
Qhov concentration ntawm HPMC hauv cov mis yog qhov tseem ceeb cuam tshuam rau qhov kub thiab txias. Cov concentrations ntau dua feem ntau ua rau cov gelation kub dua. Qhov kev sib raug zoo no yog vim muaj ntau ntawm cov saw hlau polymer muaj rau kev sib cuam tshuam hauv nruab nrab, ua rau muaj zog gel network.
2. Molecular hnyav ntawm HPMC
Qhov hnyav molecular ntawm HPMC kuj cuam tshuam rau gelation. Qhov hnyav dua molecular HPMC tuaj yeem pom qhov sib txawv gel kub piv rau qis dua molecular hnyav HPMC. Molecular hnyav cuam tshuam rau solubility ntawm cov polymer, saw entanglement, thiab lub zog ntawm gel network tsim.
3. Tus nqi dej
HPMC hydration tus nqi cuam tshuam los ntawm qhov kub thiab txias. Kev kub siab dua ua kom cov txheej txheem hydration, ua rau gelation sai dua. Qhov no yog ib qho tseem ceeb tshwj xeeb tshaj yog rau lub sij hawm-sensitive formulations uas yuav tsum tau ceev gelation.
4. Muaj cov tshuaj ntxiv
Lub xub ntiag ntawm cov khoom siv ntxiv xws li plasticizers lossis ntsev tuaj yeem hloov kho qhov kub thiab txias ntawm HPMC. Cov additives no tuaj yeem cuam tshuam nrog cov saw hlau polymer, cuam tshuam rau lawv lub peev xwm los tsim cov gel tes hauj lwm. Formulators yuav tsum ua tib zoo xav txog cov txiaj ntsig ntawm additives ntawm gel cwj pwm.
Cov ntsiab lus tseem ceeb thiab kev siv
Nkag siab txog qhov kub thiab txias ntawm tus cwj pwm ntawm HPMC yog qhov tseem ceeb rau kev tsim cov khoom lag luam nrog cov khoom zoo thiab kev ua haujlwm zoo. Qhov kev nkag siab no ua rau muaj ntau qhov cuam tshuam thiab siv tau.
1. Tswj kev tso tshuaj
Hauv kev lag luam kws tshuaj, HPMC feem ntau yog siv los tswj-tso tshuaj formulations. Qhov kub rhiab heev ntawm HPMC gels tuaj yeem siv los tswj kev tso tawm cov khoom xyaw tshuaj nquag. Los ntawm ua tib zoo kho qhov kub thiab txias, cov neeg tsim khoom tuaj yeem kho cov tshuaj tso tawm cov yeeb yaj kiab.
2. Kub-tej hydrogels
Qhov kub rhiab heev ntawm HPMC ua rau nws tsim nyog rau kev loj hlob ntawm qhov kub thiab txias teb hydrogels. Cov hydrogels no tuaj yeem hloov pauv hloov pauv sol-gel hauv kev teb rau cov kev hloov pauv hauv qhov kub thiab txias, ua rau lawv muaj txiaj ntsig zoo rau kev siv xws li kev kho qhov txhab thiab xa tshuaj.
3. Cov khoom siv hauv tsev
Hauv kev tsim kho kev lag luam, HPMC feem ntau yog siv los ua ib qho ntxiv rau cov khoom siv cement los txhim kho kev ua haujlwm thiab kev tuav dej. Qhov kub thiab txias ntawm HPMC cuam tshuam rau lub sijhawm teeb tsa thiab cov khoom siv rheological ntawm cov ntaub ntawv no, yog li cuam tshuam rau lawv cov kev ua tau zoo thaum tsim kho.
Kev sib tw thiab kev daws teeb meem
Txawm hais tias qhov kub thiab txias-dependent gel cwj pwm ntawm HPMC muaj qhov tshwj xeeb zoo, nws kuj ua rau muaj teeb meem hauv qee yam kev siv. Piv txwv li, kev ua tiav cov khoom zoo ib yam ntawm cov gel tuaj yeem nyuaj hauv cov qauv uas muaj qhov kub thiab txias. Formulators yuav tsum xav txog cov kev cov nyom no thiab siv cov tswv yim los daws lawv.
1. Kev tswj qhov kub thiab txias thaum npaj
Txhawm rau kom muaj kev ua tau zoo ntawm cov gel, kev tswj qhov kub thiab txias thaum lub sijhawm tsim khoom yog qhov tseem ceeb. Qhov no yuav suav nrog kev siv cov khoom siv sib xyaw kom sov thiab saib xyuas qhov kub thiab txias thoob plaws hauv kev tsim.
2. Polymer xaiv
Nws yog ib qho tseem ceeb uas yuav tau xaiv cov qib uas tsim nyog ntawm HPMC nrog rau qhov xav tau gel kub yam ntxwv. Cov qib sib txawv ntawm HPMC muaj nyob nrog qhov sib txawv molecular hnyav thiab qib hloov pauv, tso cai rau cov neeg tsim qauv xaiv cov polymer zoo tshaj plaws rau lawv daim ntawv thov tshwj xeeb.
3. Kev ua kom zoo ntxiv
Lub xub ntiag ntawm cov tshuaj ntxiv cuam tshuam rau qhov kub thiab txias ntawm HPMC. Tus formulator yuav tsum tau optimize hom thiab concentration ntawm additives kom ua tau raws li qhov xav tau gel zog. Qhov no yuav tsum muaj txoj hauv kev zoo thiab nkag siab zoo txog kev sib cuam tshuam ntawm HPMC thiab cov khoom ntxiv.
Hydroxypropylmethylcellulose (HPMC) yog cov khoom siv ntau yam polymer nrog cov khoom tshwj xeeb gel uas cuam tshuam los ntawm qhov kub thiab txias. Qhov kub-dependent gelation ntawm HPMC muaj qhov cuam tshuam tseem ceeb rau ntau qhov kev lag luam suav nrog kev siv tshuaj, kev tsim kho, thiab tshuaj pleev ib ce. Nkag siab txog cov yam ntxwv uas cuam tshuam rau qhov kub thiab txias, xws li polymer concentration, molecular yuag, thiab muaj cov additives, yog qhov tseem ceeb rau cov neeg tsim qauv nrhiav kev ua kom zoo dua gel rau kev siv tshwj xeeb.
Raws li kev siv thev naus laus zis thiab kev tshawb fawb txog kev tshawb fawb polymer tau nce zuj zus, kev nkag siab ntxiv txog qhov kub thiab txias ntawm tus cwj pwm ntawm HPMC tuaj yeem ua rau kev txhim kho cov qauv tshiab thiab kev siv. Lub peev xwm los ua kom zoo-kho cov khoom siv gel qhib qhov muaj peev xwm tshiab rau kev tsim cov khoom siv nrog cov khoom siv kho mob, pab kev nce qib hauv kev xa tshuaj, biomaterials thiab lwm yam.
Post lub sij hawm: Jan-11-2024