Hydroxypropyl Methyl Cellulose HPMC

Hydroxypropyl methylcellulose yog siv(HPMC) yog ib qho cellulose derivative uas feem ntau siv nyob rau hauv ntau yam lag luam, xws li tshuaj, zaub mov, kev tsim kho, thiab kev saib xyuas tus kheej. Nws yog tsim los ntawm chemically modifying cellulose los ntawm etherification, uas koom nrog qhia hydroxypropyl thiab methyl pawg rau hauv cellulose molecule.

HPMC yog cov hmoov dawb dawb uas tsis muaj ntxhiab tsw uas yog soluble hauv dej thiab tsim cov kua dej ntshiab. Nws muaj ntau yam khoom uas ua rau nws muaj txiaj ntsig hauv ntau yam kev siv. Piv txwv li, nws yog ib qho thickener, stabilizer, thiab emulsifier hauv cov khoom noj. Hauv kev tsim kho, nws yog siv los ua tus neeg saib xyuas dej hauv cov cement thiab mortar los txhim kho kev ua haujlwm thiab tiv thaiv kev tawg. Hauv cov khoom tu tus kheej, nws yog siv los ua cov thickener thiab emulsifier hauv cov tshuaj pleev, cream, thiab lwm yam khoom.

Hauv kev lag luam tshuaj, HPMC yog siv los ua ib qho kev sib khi, disintegrant, thiab tswj-tso tus neeg sawv cev hauv cov ntsiav tshuaj thiab tshuaj ntsiav. Nws kuj yog siv los ua tus neeg sawv cev ncua hauv cov kua formulations thiab ua cov roj nplua nyeem hauv cov tshuaj pleev thiab cream. HPMC yog ib qho kev lees paub dav dav hauv kev lag luam kws tshuaj vim nws biocompatibility, kev nyab xeeb, thiab tsis muaj tshuaj lom.

HPMC muaj ntau qib nrog cov qib viscosity sib txawv, uas raug xaiv los ntawm tus lej lej. Tus lej siab dua, qhov viscosity siab dua. HPMC qib ntau ntawm cov viscosity tsawg (5 cps) mus rau siab viscosity (100,000 cps). Lub viscosity ntawm HPMC yog qhov tseem ceeb hauv kev txiav txim siab nws cov khoom thiab kev siv.

Kev siv HPMC hauv cov kws tshuaj tau loj hlob nyob rau xyoo tas los no vim nws cov khoom siv ntau yam thiab qhov xav tau ntau ntxiv rau cov tshuab xa tshuaj tshiab. HPMC-raws li hydrogels tau siv rau hauv kev xa tshuaj vim lawv cov biocompatibility, tswj kev tso tawm, thiab mucoadhesive zog. HPMC-raws li cov ntsiav tshuaj kuj tau tsim nrog hloov kho-tso cov khoom uas tso cai rau kev xa tshuaj thiab txhim kho kev ua raws li tus neeg mob.

Txawm li cas los xij, HPMC tsis yog tsis muaj qhov txwv. Nws muaj cov tsis zoo solubility nyob rau hauv cov kuab tshuaj organic thiab rhiab heev rau pH hloov. Tsis tas li ntawd, nws muaj qhov ntsuas kub tsawg thiab tuaj yeem poob nws cov viscosity ntawm qhov kub thiab txias. Cov kev txwv no tau ua rau muaj kev txhim kho ntawm lwm cov cellulose derivatives, xws li hydroxyethyl cellulose (HEC) thiab carboxymethyl cellulose (CMC), uas tau txhim kho cov khoom thiab kev siv dav dua.

Nyob rau hauv xaus, HPMC yog ib tug ntau yam cellulose derivative uas yog dav siv nyob rau hauv ntau yam lag luam, tshwj xeeb tshaj yog nyob rau hauv pharmaceuticals. Nws cov yam ntxwv tshwj xeeb, suav nrog nws cov biocompatibility, kev nyab xeeb, thiab tsis muaj tshuaj lom, ua rau nws nrov excipient hauv cov tshuaj formulations. HPMC-raws li kev xa tshuaj cov tshuab tau qhia cov lus cog tseg hauv kev txhim kho kev siv tshuaj thiab kev ua raws li tus neeg mob. Txawm li cas los xij, nws cov kev txwv hauv solubility thiab pH rhiab heev tau ua rau kev txhim kho ntawm lwm cov cellulose derivatives nrog cov khoom zoo dua qub.