HPMC siv hauv cov ntsiav tshuaj txheej
ntsiav tshuaj txheej feem ntau yog siv rau hauv cov khoom npaj, raws li covntsiav tshuaj txheej cov ntaub ntawv tuaj yeem muab faib ua hmoovntsiav tshuaj txheej, pelletntsiav tshuaj txheej, particlentsiav tshuaj txheej, ntsiav tshuajntsiav tshuaj txheej, tsi capsulentsiav tshuaj txheej; Raws lintsiav tshuaj txheej cov ntaub ntawv muab faib ua qab zibntsiav tshuaj txheej, ib nrab zaj duab xisntsiav tshuaj txheej, zaj movientsiav tshuaj txheej (raws li ntau yam khoom siv polymer, suav nrog entericntsiav tshuaj txheej), cov khoom siv tshwj xeebntsiav tshuaj txheej (xws li stearic acid, paraffin, polysaccharide); Raws lintsiav tshuaj txheej technology, nws tuaj yeem muab faib ua tshuaj tsuagntsiav tshuaj txheej,dabntsiav tshuaj txheej, qhuav siabntsiav tshuaj txheej, electrostaticntsiav tshuaj txheej thiab laminatingntsiav tshuaj txheej. Ntawm lawv, tshuaj tsuagntsiav tshuaj txheej yog qhov siv ntau tshaj plaws. Nws lub hauv paus ntsiab lus yog tshuaj tsuagntsiav tshuaj txheej kua rau hauv cov pos nphuab npog cov khoom siv (hmoov, hais, ntsiav tshuaj). Thiab sai sai qhuav rau daim ntawvntsiav tshuaj txheej txheej: raws li covntsiav tshuaj txheej Lub hom phiaj muab faib ua dej solublentsiav tshuaj txheej, plab solublentsiav tshuaj txheej, insolublentsiav tshuaj txheej, tso qeebntsiav tshuaj txheej, entericntsiav tshuaj txheej.
Lub luag haujlwm ntawmntsiav tshuaj txheej suav nrog: (1) noo noo tsis kam, lub teeb, huab cua cais tawm kom muaj kev ruaj ntseg ntawm cov tshuaj; (2) Npog cov ntxhiab tsw phem, txo qhov stimulation; (3) Txhim kho qhov tsos, yooj yim los txheeb xyuas; (4) Tswj cov tshuaj tso tawm qhov chaw, xws li hauv cov kua txiv hmab txiv ntoo yooj yim raug rhuav tshem kom nws tawm hauv cov hnyuv: (5) tswj cov tshuaj dispersion, tso tawm ceev: (6) kov yeej incompatibility, thiab lwm yam.ntsiav tshuaj txheej Cov khoom siv yuav tsum muaj cov hauv qab no: tsis muaj tshuaj lom, tsis muaj tshuaj lom neeg inertia, ruaj khov hauv tshav kub, lub teeb, dej, cua, thiab tsis hnov mob nrogntsiav tshuaj txheej tshuaj; (2) tuaj yeem yaj rau hauv qhov sib npaug sib npaug hauv qhov nruab nrab dispersion haum rauntsiav tshuaj txheej: (3) tuaj yeem tsim cov txheej txheem txuas ntxiv, ruaj khov, du, tawg tsis kam thiab muaj kev sib cais dej zoo, kev cais tawm noo noo, shading, huab cua permeability;④Nws solubility yuav tsum tau raws li qhov yuav tsum tau ntawm - tsau, qee zaum yuav tsum tsis txhob cuam tshuam los ntawm PH, qee zaum tsuas yog yaj hauv ib qho PH ntau. Ib hom khoom uas muaj cov yam ntxwv saum toj no tib lub sijhawm tsis pom ntau, vim li cas thiaj li siv sib xyawntsiav tshuaj txheej cov ntaub ntawv ntau, thiaj li kawm tau ntawm ib leeg.
Tabletntsiav tshuaj txheej yog qhov siv ntau tshaj plaws, nws feem ntau siv lub lauj kaubntsiav tshuaj txheej thiab faus lub cevntsiav tshuaj txheej (high efficiencyntsiav tshuaj txheej tshuabntsiav tshuaj txheej), tom kawg yog zoo dua rau zaj duab xisntsiav tshuaj txheej. Fluidized txajntsiav tshuaj txheej yog tsim nyog rau cov ntaub ntawv nrog me me particle loj xws li pellets thiab hmoov. Piv nrog qab zibntsiav tshuaj txheej, zaj movientsiav tshuaj txheej muaj ntau yam zoo 1) Txo lub sijhawm thiab txo cov nqi khoom siv; (2) tsis muaj qhov hnyav nce ntxiv: (3) tsis xav tau txheej hauv qab: (4) muaj zog, crushing thiab cracking kuj: (5) tuaj yeem luam tawm, kuj tsis cuam tshuam rau daim ntawv nti; (6) tuaj yeem tiv thaiv cov khoom zoo los ntawm kev cuam tshuam ntawm lub teeb, huab cua thiab dej; (7) Tsis muaj kev cuam tshuam rau lub sijhawm tawg 8) khoom aesthetic 9) muab lub sijhawm rau siv tsis yog dejntsiav tshuaj txheej; Cov txheej txheem thiab cov ntaub ntawv tuaj yeem ua tus qauv. Tam sim no txoj kev loj hlob ntawm cov khoom tshiabntsiav tshuaj txheej kev npaj feem ntau txais yuav zaj duab xisntsiav tshuaj txheej, zaj movientsiav tshuaj txheej Cov tshuaj muaj pes tsawg leeg muaj xws li tus neeg sawv cev ua yeeb yaj kiab (ntsiav tshuaj txheej khoom), hnyav, plasticizer, colorant, kuj ntxiv pore-ua tus neeg sawv cev, insoluble muab tub lim, thiab lwm yam .. Cov muaj pes tsawg leeg ntawm zaj duab xisntsiav tshuaj txheej tshuaj yog tus yuam sij rau txoj kev vam meejntsiav tshuaj txheej. Tam sim no, dej-soluble zaj duab xisntsiav tshuaj txheej Cov khoom siv feem ntau suav nrog hydroxypropyl methyl cellulose (HPMC) thiab hydroxypropyl cellulose (HPC). Polyethylene glycol (PEG), polyethylene pyrrolidone (PVP), enteric-soluble cov ntaub ntawv suav nrog enteric-soluble acrylic resin, hydroxypropyl methyl cellulose phthalate (HPMCP). Cellulose acetate phthalate ester (CAP). Shellac, insoluble cov ntaub ntawv muaj xws li ethyl cellulose (EC), zein.
Tau ntau xyoo, ua yeeb yaj kiabntsiav tshuaj txheej tau ua tau zoo kawg li. Cov qauv kev caintsiav tshuaj txheej siv qhov systemHPMC(hydroxypropyl methylcellulose) ua lub ntsiab polymer, uas tseem siv dav niaj hnub no. HPMC-raws lintsiav tshuaj txheej systems muab kev ua tau zoo txaus, tab sis tseem muaj chaw rau kev txhim kho. HPMCntsiav tshuaj txheej zaj duab xis yuav tsis ua raws li cov ntsiav tshuaj zoo, feem ntau ntevntsiav tshuaj txheej lub sijhawm, ua rau qeeb ntau lawm. Cov lus qhia tom ntej ntawmPVA raws ntsiav tshuaj txheej systems tau txhim kho kev ua haujlwm ntxiv, ua kom zoo dua qubntsiav tshuaj txheej kev ua tau zoo thiab kev tsim khoom sai dua, uas txhais tau hais tias qhov tsis xws luag yuav tshwm sim tsawg dua hauv cov ntsiav tshuaj.
Raws li qhov viscosity ntawm HPMC nce, lub zog ntawm cov yeeb yaj kiab tsim los ntawm HPMC nce ntxiv, thiab thaum kawg mus txog qhov siab tshaj plaws zaj duab xis lub zog tsis nce ntxiv nrog qhov nce ntawm viscosity ntawm HPMC.
Hauvntsiav tshuaj txheej, txhawm rau ua kom tau txais txiaj ntsig zoo tshaj plawsntsiav tshuaj txheej, feem ntau txhim kho covntsiav tshuaj txheej kua khoom cov ntsiab lus, uas yuav ua rau lubntsiav tshuaj txheej kua viscosity siab dhau lawm, xaiv cov viscosity tsawg HPMC tuaj yeem daws qhov teeb meem no tau zoo, tab sis ua rau lub zog ntawm zaj duab xis cuam tshuam. Txhawm rau sib npaug cov teeb meem ntxaib no, kev sib xyaw polymers tau dhau los ua ib qho cuab yeej siv.
Raws li covHPMCE15 cov ntsiab lus maj mam nce, lub viscosity ntawm qhov sib tov ntawmHPMCE5 thiabHPMCE15 kuj maj mam nce.
Hauv qab zibntsiav tshuaj txheej, peb kuj tau mus ntawm kos duab mus rau science. Cov khoom qab zib-coated yog qhov ua kom zoo nkauj vim tias lawv muaj qhov sib luag, ci ntsa iab, qab zib tiav uas npog qhov ncauj qab. Tab sis qhov teeb meem loj tshaj plaws hauv qab zibntsiav tshuaj txheej dag nyob rau hauv productivity thiab reproducibility. Qab Zibntsiav tshuaj txheej yog ib qho kev siv zog heev thiab siv sij hawm siv cov txheej txheem thiab yuav txawv ntawm batch mus rau batch nyob ntawm tus neeg ua haujlwm.ntsiav tshuaj txheej.
Post lub sij hawm: Dec-23-2023