HPMC Cov Txheej Txheem Tsim Kev
Cov txheej txheem tsim khoom rauHydroxyPropyyl Methylcellulose (HPMC)koom nrog cov tshuaj lom neeg, tshuab, thiab cov kauj ruam thermal. Cov txheej txheem pib nrog sourcing raw cellulose los ntawm ntuj fibers thiab xaus nrog kev tsim khoom zoo, cov hmoov qhuav uas haum rau ntau yam kev siv. Cov ncauj lus qhia ntxaws ntxaws qhia txhua kauj ruam hauv HPMC cov txheej txheem ntau lawm, suav nrog kev sib tawg, cov khoom siv raw, thiab kev tswj hwm zoo, thiab kev tswj hwm zoo.
Taw qhia rau HPMC Raug
HydroxyPropyyl Methylcellulose(HPMC) yog lub cellulose ether tau siv nyob rau hauv ntau yam kev siv, xws li cov khoom siv stabas), xws li cov khoom siv khov kho lossis cov khoom siv saib xyuas tus kheej), thiab lwm yam. Nws cov khoom muaj xws li cov dej tuav cia, ua yeeb yaj kiab ua yeeb yam, muaj peev xwm ua yeeb yam siab, thiab yooj yim ntawm kev hloov kho.
HPMC yog tsim los ntawm kev hloov cellulose cellulose, lub ntuj muaj zog rho tawm los ntawm cov nroj tsuag cov fibers. Los ntawm lub etherification txheej txheem, tshwj xeeb pab pawg-methylthiabHydroxyPropylPawg-tau qhia rau cellulose molecules, yog li hloov nws lub cev thiab tshuaj siv tshuaj. Cov kev hloov kho no cuam tshuam cov yam ntxwv zoo li cov dej solubility, txhim kho cov khoom ntws, thiab gelling cov khoom rau cov khoom.
Cov ntu hauv qab no muab cov ncauj lus kom ntxaws ntxaws ntawm cov kauj ruam koom nrog HPMC, npog cov txheej txheem raw, thiab cov kauj ruam tom qab tsim khoom.
1. Cov Khoom Siv Khoom Raw
Cov khoom siv thawj rau HPMC ntau lawm yogCellulose, uas yog muaj los ntawm cov nroj tsuag fibers, feem ntau ntawm cov ntoo lossis cov paj rwb. Lub cellulose yuav tsum yauv los ntawm kev kho kom tshem tawm impurities thiab npaj nws rau txheej txheem etherification. Qhov no ua kom pom tseeb tias lub cellulose yog huv thiab reagentive.
1.1. Sourcing thiab purification ntawm cellulose
| Mus ib ruam taw | Kev ua | Cov ntsiab lus |
|---|---|---|
| Cellulose Sourcing | Tau txais cov cellulose los ntawm ntuj fibers, xws li ntoo pulp lossis cov paj rwb. | Lub cellulose yuav tsum muaj siab purity kom ntseeg tau tias zoo HPMC. |
| Huv | Tshem tawm cov khoom siv tsis-cellulose, xws li livin thiab hmicellulose, siv alkali kho. | Feem ntau, sodium hydroxide (Naoh) lossis potassium hydroxide (koh) yog siv los txhuam cov poj ntxas poj niam thiab hnav. |
| Ntxuav | Yaug nrog dej kom tshem tawm cov tshuaj uas tseem ceeb. | Rinsing tshem tawm ntau dhau alkali thiab lwm yam impurities kom ntseeg tau tias lub cellulose yog ntshiab. |
Lub cellulose fibers tau ua tiav thiab qhuav kom ua tiav cov ntsiab lus noo noo, uas yog qhov tseem ceeb rau cov kauj ruam tom ntej.
1.2. Ua ntej Kev Kho Mob nrog Alkali
Cellulose fibulose yog kho nrog sodium hydroxide (Naoh) daws los ua kom cov fibers ntau reactive thiab qhib lawv cov qauv. Qhov no hu uaKev Kho Mob Alkali or kev ua kom ua kom muaj zog, thiab nws yog ib qib tseem ceeb hauv cov txheej txheem.
| Mus ib ruam taw | Kev ua | Cov ntsiab lus |
|---|---|---|
| Alkali Ua Haujlwm | Lub cellulose yog soaked nyob rau hauv ib qho kev daws teeb meem alkaline (NAOH) rau ob peb teev ntawm qhov kub ntawm huab cua sov. | Lub alkaline cov tshuaj nrog cov cellulose, ua rau muaj kev siv dab tsi ntxiv rau lub Etherification txheej txheem. |
| Txias | Tom qab kho, qhov sib tov sab laug kom so rau ob peb teev lossis hnub. | Qhov no tso cai tso cai rau cov cellulose fibulose kom ruaj khov thiab xyuas kom haum rau cov kauj ruam tom ntej. |
2. Ethetification txheej txheem
Etherification yog cov txheej txheem uas lub cellulose tau ua rauMethyl chloride (Ch₃cl)thiabPropylene Oxide (C₃H₆O)los qhia methyl (ch ₃) thiab hydroxypropyl (C₃h₆oh) pawg, hloov cellulose rau hauvHydroxyPropyyl Methylcellulose (HPMC).
Qhov no yog qhov tseem ceeb tshaj plaws theem ntawm HPMC kev tsim khoom, raws li nws txiav txim siab cov khoom zoo thiab cov khoom ntawm cov khoom kawg.
2.1. Methylation (methyl pab pawg ntxiv)
Lub cellulose fibers yog thawj rechared nrogMethyl ChlorideNyob rau hauv lub xub ntiag ntawm lub hauv paus (feem ntau sodium hydroxide, Naoh), uas qhia cov methyl pawg (-ch₃) rau hauv cov qauv cellulose.
| Mus ib ruam taw | Kev ua | Cov ntsiab lus |
|---|---|---|
| Metylation | Cellulose yog siv nrog methyl chloride (ch₃cl) nyob rau hauv lub xub ntiag ntawm Naoh. | Cov tshuaj tiv thaiv qhia me methyl pawg (-ch₃) mus rau lub cellulose saw. Cov foos noMethylcellulose (MC)ua ib nrab. |
| Cov tshuaj tiv thaiv | Cov tshuaj tiv thaiv yog ua tib zoo tswj hwm nyob rau hauv cov nqe lus ntawm kub (30-50 ° C) thiab sijhawm. | Siab dhau qhov kub yuav ua rau cov kev tsis txaus siab, thaum tsis tshua muaj qhov kub thiab txias tsawg tuaj yeem txo cov qib kev hloov pauv. |
Tus nqi ntawm methylation txiav txim siab tusdegree ntawm hloov (DS), uas cuam tshuam rau solubility thiab viscosity ntawm cov khoom kawg.
2.2. HydroxyPropy (Hydroxypropropyl Pab Pawg Ntxiv)
Lub cellulose yog tom qab ntawd reacted nrogPropylene Oxide (C₃H₆O)los qhiahydroxypropyl pawg (-C₃h₃oh), uas muab HPMC nws cov yam ntxwv zoo, xws li dej solubility thiab viscosity.
| Mus ib ruam taw | Kev ua | Cov ntsiab lus |
|---|---|---|
| HydroxyPropYrodation | Lub cellulose methylated tau kho nrog cov tsiaj ntawv pleev tshuaj oxide nyob rau hauv kev tswj hwm. | Cov tshuaj tiv thaivHydroxyPropyyl Methylcellulose (HPMC). |
| Catalysis | Sodium hydroxide lossis sodium carbonate yog siv ua catalyst. | Lub hauv paus yuav pab ua kom lub zog ntawm cov tshuaj pleev kom ua rau cov tshuaj tiv thaiv. |
Cov qib ntawm hydroxypropyl hloov kuj cuam tshuam cov khoom kawg ntawm HPMC, xws li nws viscity, solubility, thiab muaj peev xwm ua cov yeeb yaj kiab.
2.3. Etherification cov tshuaj tiv thaiv tswj
Lub here cov tshuaj tiv thaiv feem ntau yog nqa tawm hauv aReactor Rau Reverelhauv qabTswj kub thiab siabCov. Cov xwm txheej raug yog raws li hauv qab no:
| Chaw ua uas tsis tau haus | Yam xwm txheej |
|---|---|
| Qho so | 30 ° C txog 60 ° C |
| Nyem | Atmospheric los yog ib nyuag tsa siab |
| Lub sijhawm | 3 txog 6 teev, nyob ntawm seb cov qib xav tau |
Cov tshuaj tiv thaiv yuav tsum tau ua tib zoo tswj kom ntseeg tau tias yog ib tug unencal etherification thiab zam dhau qhov tsis tiav.
3. Neutralization thiab ntxuav
Tom qab cov txheej txheem etherification, cov tshuaj tiv thaiv sib tov muaj cov tshuaj alkali thiab siv tshuaj lom neeg ntau dhau. Cov no yuav tsum tau neutralized thiab muab tshem tawm kom ntseeg tau tias qhov kawg HPMC zaum kawg yog kev nyab xeeb, ntshiab, thiab ua tau raws li cov lus qhia tshwj xeeb.
3.1. Nruab nrab
| Mus ib ruam taw | Kev ua | Cov ntsiab lus |
|---|---|---|
| Nruab nrab | Ntxiv cov kua qaub tsis muaj zog, xws li hydrochloric acid (HCl), mus nruab nrab ntau dhau naoh. | Cov kua qaub nruab nrab ntawm cov khoom seem alkaline. |
| Txom Nyem | Xyuas kom meej tias Ph ntawm qhov sib tov yog neutralized (pH 7) ua ntej txheej txheem rau kauj ruam tom ntej. | Neutralization pab zam cov teeb meem nrog cov khoom kawg kev ruaj ntseg. |
3.2. Ntxuav
| Mus ib ruam taw | Kev ua | Cov ntsiab lus |
|---|---|---|
| Ntxuav | Ntxuav cov kev sib xyaw nruab nruab nrab kom huv si nrog dej. | Ntau cov dej ntxhua yuav tsum tau tshem tag nrho cov tshuaj muaj kuab lom thiab cov khoom lag luam. |
| Huv | Cov khoom yog lim kom tshem tawm cov khoom siv tsis muaj txiaj ntsig lossis tsis txaus ntseeg. | Cov kauj ruam no ua kom ntseeg tau tias cov khoom kawg yog cov khoom huv thiab tsis muaj tshuaj paug. |
4. Kom qhuav thiab hmoov
ThaumHPMCSlurry yog neutralized thiab lim, cov kauj ruam tom ntej yog kom qhuav kom hloov cov khoom ua hmoov zoo. Cov txheej txheem ziab yog ua tib zoo tswj kom muaj cov tshuaj lom neeg ntawm HPMC.
4.1. Kom qhuav
| Mus ib ruam taw | Kev ua | Cov ntsiab lus |
|---|---|---|
| Kom qhuav | Lub lim HPMC slurry yog qhuav, feem ntau sivTxau Kom Qhuav, Nruas Kom Qhuav, lossiskhov kom qhuavCov tswv yim. | Txau kom qhuav yog cov qauv ntau tshaj plaws, qhov twg cov slurry yog atomized thiab qhuav hauv huab cua kub kub. |
| Tswj Qhov Kub | Qhov kub yog ua tib zoo tswj kom tsis txhob muaj kev tsis txaus ntseeg ntawm lub cellulose ether. | Feem ntau, qhov kub ntawm 50 ° C rau 150 ° C siv tau siv, nyob ntawm txoj kev ziab. |
4.2. Sib tsoo thiab sieving
| Mus ib ruam taw | Kev ua | Cov ntsiab lus |
|---|---|---|
| Kev sib tsoo | Lub HPMC qhuav yog av rau hauv cov hmoov zoo. | Qhov no ua kom muaj zog uniform particle loj muab faib. |
| Sieving | Cov hmoov HPMC yog sieved kom ua tiav cov khaub ncaws tsis sib xws. | Xyuas kom meej tias cov hmoov muaj qhov xav tau flowability thiab particle loj muab faib. |
5. Tswjhwm thiab kuaj
Ua ntej qhov khoom HPM kawg yog ntim thiab xa khoom, nws undergoes nyuaj kev ntsuam xyuas kom ntseeg tau tias nws raws li kev lag luam tus qauv kev lag luam.
5.1. Viscosity Testing
| Mus ib ruam taw | Kev ua | Cov ntsiab lus |
|---|---|---|
| Viscosity Ntsuas Ntsuas | Ntsuas cov viscosity ntawm cov qauv daws teeb meem ntawm HPMC hauv dej. | Lub viscosity ntawm HPMC yog qhov tseem ceeb rau kev siv xws li cov nplaum, cov txheej txheem, thiab cov khoom siv. |
5.2. Yauv cov ntsiab lus
| Mus ib ruam taw | Kev ua | Cov ntsiab lus |
|---|---|---|
| Kev Kuaj Dej noo | Kuaj rau seem ya raws cov ntsiab lus. | Tshaj noo noo tuaj yeem ua rau tsis zoo ua tau zoo hauv qee cov ntawv thov. |
5.3. Kev Purity thiab Txhaws kuaj
| Mus ib ruam taw | Kev ua | Cov ntsiab lus |
|---|---|---|
| Purity tsom xam | Ntsuam xyuas cov kev coj dawb huv ntawm HPMC siv cov txuj ci zoo li chromatography. | Xyuas kom cov HPMC tsis muaj cov tshuaj uas muaj cov tshuaj uas tsis raug. |
6. Ntim
Thaum HPMC hla txhua qhov kev ntsuas zoo, nws tau ntim rau hauvlub hnab, lub nruas, lossistus mobNyob ntawm cov neeg siv khoom xav tau.
| Mus ib ruam taw | Kev ua | Cov ntsiab lus |
|---|---|---|
| Ntim | Ntim cov khoom lag luam HPM kawg rau hauv cov thawv tsim nyog. | Cov khoom yog tom qab ntawd npaj rau cov zaub mov xa tuaj rau cov neeg siv khoom. |
| Daim fab xwb | Cov ntawv sau kom zoo nrog cov lus qhia tshwj xeeb, tus lej pob, thiab cov lus qhia daws teeb meem. | Cov ntawv lo tau muab cov ntaub ntawv tseem ceeb rau cov neeg siv khoom. |
Tag
Kev tsim khoom lag luam rau hydroxypropy cettralcellulose (HPMC) cuam tshuam ntau cov theem kev tswj hwm thiab ua kom huv ntawm cellulose mus rau cov khoom kawg ntawm cov khoom. Txhua kauj ruam ntawm cov txheej txheem cuam tshuam qhov ua tau zoo thiab cov khoom ntawm HPMC, xws li kev viscosity, solubility, thiab zaj duab xis-tsim muaj peev xwm.
Nkag siab txog cov txheej txheem nyob rau hauv kev nthuav dav kom cov khoom lag luam tuaj yeem ua kom cov khoom lag luam zoo uas tau ua kom tau kev lag luam, los ntawm kev tsim kho rau cov tshuaj.
Lub sijhawm Post: Feb-07-2025