Hydroxypropyl methylcellulose (HPMC) thiab hydroxyethyl cellulose (HEC) yog cellulose ethers uas tau siv dav hauv ntau lub lag luam vim lawv cov khoom tshwj xeeb. Cov cellulose ethers no muaj ntau yam kev siv, xws li los ntawm cov khoom siv rau kev siv tshuaj thiab cov khoom siv tu tus kheej. Thaum HEC yog ib qho kev xaiv tseem ceeb rau ntau xyoo, HPMC tau txais kev muaj koob npe nyob rau xyoo tas los no raws li lwm txoj kev siv nyiaj ntau dua.
1. Taw qhia rau HPMC thiab HEC:
1.1 Hydroxypropylmethylcellulose (HPMC):
HPMC yog hloov kho cellulose ether los ntawm kev kho cellulose nrog propylene oxide thiab methyl chloride. Qhov kev hloov kho no nthuav tawm cov khoom xws li txhim kho cov dej khaws cia, thickening peev xwm thiab adhesion. HPMC paub txog nws txoj kev siv ntau yam thiab siv dav hauv kev tsim kho, tshuaj, khoom noj thiab lwm yam lag luam.
1.2 Hydroxyethylcellulose (HEC):
HEC yog lwm cellulose ether tau los ntawm reacting cellulose nrog ethylene oxide. Zoo li HPMC, HEC muaj cov dej tuav tau zoo thiab ua kom tuab. Nws yog feem ntau siv rau hauv daim ntawv thov xws li cov xim, cov nplaum, cov khoom tu tus kheej thiab cov tshuaj.
2. Kev ua tau zoo ntawm HPMC thiab HEC:
2.1 Kev tuav dej:
HPMC thiab HEC yog hydrophilic thiab muaj peev xwm tuav tau dej zoo heev. Lawv tuaj yeem nqus tau thiab khaws cov dej noo, uas ua rau lawv muaj txiaj ntsig hauv cov ntawv thov uas tswj cov dej noo yog qhov tseem ceeb, xws li cov khoom siv.
2.2 Thickening peev xwm:
Ib qho ntawm cov haujlwm tseem ceeb ntawm HPMC thiab HEC yog los ua cov thickeners. Lawv tuaj yeem ua rau kom cov viscosity ntawm cov kev daws teeb meem thiab ua rau muaj kev ruaj ntseg ntawm ntau yam formulations, nrog rau cov xim, cov nplaum thiab cov khoom tu tus kheej.
2.3 Adhesion:
Cov khoom nplaum ntawm HPMC thiab HEC ua rau lawv tsim nyog siv rau hauv cov khoom siv thiab cov tshuaj formulations. Lawv pab txhim kho adhesion thiab cohesion nyob rau hauv ntau yam kev siv.
2.4 Film tsim:
HPMC thiab HEC tuaj yeem tsim cov yeeb yaj kiab nyias thaum siv rau qhov chaw. Cov cuab yeej no muaj txiaj ntsig zoo hauv kev lag luam xws li tshuaj thiab khoom noj khoom haus, uas yuav xav tau cov yeeb yaj kiab rau cov tshuaj pleev xim los yog cov tshuaj pleev xim.
3. Kev thov ntawm HPMC thiab HEC:
3.1 Kev tsim kho kev lag luam:
Hauv kev tsim kho kev lag luam, HPMC thiab HEC tau siv dav hauv cov khoom siv cement. Lawv ua raws li cov dej tuav cov neeg ua haujlwm, txhim kho kev ua haujlwm thiab txo qhov kev pheej hmoo ntawm kev tawg. HPMC, tshwj xeeb tshaj yog, tab tom muaj kev lees paub ntau ntxiv hauv thaj chaw vim nws qhov txiaj ntsig zoo.
3.2 Tshuaj:
Nyob rau hauv cov tshuaj formulations, ob lub cellulose ethers muaj ntau yam kev siv, xws li raws li binders, disintegrants, thiab film-forming agents. HPMC feem ntau nyiam vim tias nws tau txais txiaj ntsig zoo thiab tsis cuam tshuam kev ua haujlwm.
3.3 Cov khoom tu tus kheej:
Hauv cov khoom tu tus kheej xws li tshuaj zawv plaub hau, tshuaj pleev ib ce thiab tshuaj pleev, HPMC thiab HEC ua raws li cov kua nplaum thiab cov stabilizers. Tus nqi-zoo ntawm HPMC ua rau nws yog ib qho kev xaiv zoo nkauj rau cov tuam txhab nrhiav kev lag luam.
3.4 Xim thiab Txheej:
HEC feem ntau yog siv rau hauv kev lag luam coatings vim nws cov khoom rheological, uas pab txhim kho txheej viscosity thiab daim ntawv thov yam ntxwv. HPMC kuj tseem siv rau hauv cov txheej txheem los muab cov kev daws teeb meem zoo rau kev ua tiav qhov kev xav tau.
4. Tus nqi-zoo ntawm HPMC:
4.1 Raw khoom nqi:
Kev tsim tawm ntawm HPMC suav nrog cov tshuaj tiv thaiv ntawm cellulose nrog propylene oxide thiab methyl chloride, uas feem ntau siv nyiaj ntau dua li cov ethylene oxide siv hauv HEC ntau lawm. Qhov no muab HPMC qhov kev sib tw kom zoo dua ntawm cov nqi raw khoom.
4.2 Cov txheej txheem tsim khoom:
Lub synthesis ntawm HPMC yog cov txheej txheem yooj yim uas pab txo cov nqi tsim khoom. Qhov yooj yim ntawm cov txheej txheem tsim khoom ua rau HPMC qhov kev xaiv zoo tshaj plaws rau kev lag luam nrhiav kev txhim kho cov nqi yam tsis muaj kev cuam tshuam zoo.
4.3 Tus nqi siv tau:
Thaum HPMC thiab HEC muab cov kev ua tau zoo sib xws hauv ntau daim ntawv thov, tus nqi-zoo ntawm HPMC feem ntau ua rau nws xaiv thawj zaug rau cov tuam txhab. Qhov sib npaug ntawm kev ua tau zoo thiab tus nqi yog qhov tseem ceeb hauv kev xaiv cov khoom siv raw, thiab HPMC ua tau zoo tshaj plaws hauv kev xa cov nqi zoo rau cov nyiaj.
5 Xaus:
Hauv kev xaus, hydroxypropyl methylcellulose (HPMC) tau tshwm sim los ua ib qho txiaj ntsig zoo dua rau hydroxyethyl cellulose (HEC) hauv ntau qhov kev lag luam. Cov khoom zoo sib xws ntawm cov cellulose ethers no ua rau HPMC yog ib qho kev xaiv zoo rau cov ntawv thov xws li cov khoom siv hauv tsev, tshuaj, thiab cov khoom tu tus kheej. Tus nqi kom zoo dua ua ke nrog nws cov kev ua tau zoo ntau yam ua rau HPMC thawj qhov kev xaiv rau cov tuam txhab nrhiav kev lag luam uas tsis muaj kev cuam tshuam qhov zoo ntawm cov khoom kawg. Raws li kev lag luam txuas ntxiv txhim kho thiab saib xyuas tus nqi ua haujlwm tseem ceeb, HPMC zoo li yuav tswj hwm nws txoj kev nce qib raws li tus nqi-zoo cellulose ether nrog ntau daim ntawv thov.
Post lub sij hawm: Dec-05-2023