HPMC hauv Pharmaceuticals

Cov tshuaj excipient hydroxypropyl methyl cellulose (HPMC) yog ib qho uas tsis yog-ionic cellulose ether excipients, yog tam sim no qhov loj tshaj plaws hauv tsev thiab txawv teb chaws siv cov tshuaj excipients - a, raws li cov tshuaj excipient muaj ntau tshaj 30 xyoo keeb kwm. Nws yog odorless, tasteless, non-toxic, soluble nyob rau hauv dej txias, gelation nyob rau hauv dej kub, tsis tshua muaj viscosity theem HPMC yuav siv tau raws li ib tug nplaum, stickiness tus neeg saib xyuas thiab ncua kev kawm ntawv tus neeg saib xyuas siab viscosity theem HPMC yuav siv tau los npaj cov ntaub ntawv sib xyaw ua ke txhawb nqa-tso tawm. ntsiav tshuaj, sustained-tso capsules, hydrophilic gel moj khaum sustained-tso ntsiav tshuaj blocker, tswj tso tawm tus neeg saib xyuas thiab pore channel tus neeg sawv cev.

Pharmaceutical excipient cov ntaub ntawv xa mus rau excipients thiab adjuncts siv nyob rau hauv kev tsim thiab dispensing tshuaj. Ib yam khoom, uas tsis yog cov khoom xyaw nquag, uas tau raug soj ntsuam zoo rau kev nyab xeeb thiab suav nrog hauv cov khoom siv tshuaj. Pharmaceutical excipients muaj lub luag haujlwm tseem ceeb ntawm solubilizing, pab kev tawg, qeeb thiab tswj kev tso tawm ntxiv rau kev tsim, sau cov cab kuj thiab txhim kho kev ruaj ntseg, uas yuav cuam tshuam rau qhov zoo, kev nyab xeeb thiab kev ua tau zoo ntawm cov tshuaj.

Hydroxypropyl methyl cellulose HPMC yog ib qho ntawm cov tshuaj loj tshaj plaws nyob rau hauv tsev thiab txawv teb chaws, uas tau siv los ua tshuaj excipients rau xyoo. Nws yog odorless, tasteless thiab non-toxic, soluble nyob rau hauv dej txias thiab gelatinous nyob rau hauv dej kub. HPMC raws li ib tug natural hydrophilic polymer tshuaj auxiliary cov ntaub ntawv, tsis tsuas yog siv tau raws li cov ntsiav tshuaj, granule, ntsiav tshuaj nplaum thiab disintegrant, zaj duab xis txheej khoom, kuj yuav siv tau raws li ib tug colloidal neeg sawv cev thiab ncua kev kawm ntawv tus neeg saib xyuas, qeeb tso tawm thiab tswj kev tso tawm npaj blocker, tswj. tso tawm tus neeg sawv cev thiab pore-ua tus neeg sawv cev, nrog rau cov cab kuj ntawm cov khoom dispersion.

HPMC ua tus binder thiab disintegrating tus neeg sawv cev. HPMC raws li ib tug binder tuaj yeem txo qhov kev sib cuag Angle ntawm cov tshuaj, kom cov tshuaj tau yooj yim ntub, thiab nws tus kheej cov dej tuaj yeem nthuav dav ntau pua zaus, yog li nws tuaj yeem txhim kho qhov kev sib cais lossis tso tawm cov ntsiav tshuaj. HPMC muaj zog viscosity, rau kev ntxhib los mos ntawm nkig los yog tawv tawv raw cov ntaub ntawv tuaj yeem txhim kho nws cov viscosity particle, txhim kho nws cov compressibility. HPMC tsis tshua muaj viscosity yuav siv tau raws li ib tug binder thiab disintegrating tus neeg sawv cev, siab viscosity nkaus xwb raws li ib tug binder, tus nqi sib txawv raws li tus qauv thiab cov yuav tsum tau, tus nqi yog 2% -5%.

HPMC yog siv los tswj cov khoom tso tawm rau kev npaj qhov ncauj. HPMC yog cov khoom siv hydrogel uas feem ntau siv hauv kev npaj tso tawm. HPMC nrog qib viscosity tsawg (5 ~ 50mPa•s) tuaj yeem siv los ua binder, nplaum-txhim kho tus neeg saib xyuas thiab ncua kev pab cuam, thaum HPMC nrog qib siab viscosity (4000 ~ 100000mPa•s) tuaj yeem siv los npaj cov ntaub ntawv sib xyaw ua ke txhawb nqa-tso tawm ntsiav tshuaj, sustained-tso capsules, hydrophilic gel moj khaum sustained-tso ntsiav tshuaj raws li ib tug blocker. HPMC tuaj yeem yaj hauv cov kua dej hauv plab, muaj qhov zoo ntawm kev ua haujlwm zoo, kev ua haujlwm zoo, muaj peev xwm thauj cov tshuaj muaj zog thiab cov tshuaj tso tawm cov yam ntxwv tsis cuam tshuam los ntawm pH, thiab lwm yam. siv los ua hydrophilic gel moj khaum thiab txheej txheej ntawm kev npaj tso tawm, thiab siv rau hauv kev npaj plab hnyuv, txhawb kev tso tawm cov tshuaj yeeb yaj kiab excipients.

HPMC li txheej zaj duab xis tsim tus neeg sawv cev. HPMC muaj cov yeeb yaj kiab zoo, nws tsim cov yeeb yaj kiab pob tshab, tawv, ntau lawm tsis yooj yim rau lo, tshwj xeeb tshaj yog rau kev nqus dej yooj yim, cov tshuaj tsis ruaj khov, nrog rau nws cov txheej txheem kev sib cais tuaj yeem txhim kho kev ruaj ntseg ntawm cov tshuaj, tiv thaiv zaj duab xis discoloration. Piv nrog rau gelatin zaj duab xis tsim, HPMC zaj duab xis muaj zoo uniformity thiab lub teeb transmittance. HPMC muaj ntau yam viscosity specifications, tsim nyog xaiv, txheej zoo, tsos zoo dua li siv lwm yam ntaub ntawv, nws feem ntau siv concentration ntawm 2% -10%.

HPMC ua tus neeg sawv cev ncua. Suspended kua npaj yog feem ntau siv nyob rau hauv cov ntaub ntawv kho mob ntau npaum, uas yog heterogeneous dispersion systems ntawm insoluble khoom tshuaj nyob rau hauv cov kua dispersion media. Qhov kev ruaj ntseg ntawm lub kaw lus txiav txim siab qhov zoo ntawm kev tshem tawm cov kua ua kua. HPMC colloidal tov tuaj yeem txo cov khoom-kua interface nro, txo qhov saum npoo tsis muaj zog ntawm cov khoom siv, kom cov txheej txheem sib txawv ntawm qhov sib txawv zoo li ruaj khov, yog tus neeg sawv cev zoo tshaj plaws. HPMC yog siv los ua cov thickener rau qhov muag te, nrog cov ntsiab lus ntawm 0.45% -1.0%.