HPMC rau veterinary tshuaj

Hydroxypropyl methylcellulose (HPMC) yog cov khoom siv dav siv polymer hauv kev lag luam kws tshuaj, thiab nws kuj tseem siv rau hauv kev npaj cov tshuaj kho tsiaj. HPMC yog cov dej-soluble, uas tsis yog-ionic cellulose ether uas yog muab los ntawm ntuj cellulose. Nws yog ib qho kev nyab xeeb, biocompatible, thiab biodegradable polymer uas yog siv los txhim kho kev ruaj ntseg, rheological zog, thiab bioavailability ntawm veterinary tshuaj. Hauv tsab xov xwm no, peb yuav tham txog cov khoom thiab kev siv ntawm HPMC hauv cov kws kho tsiaj.

Cov cuab yeej ntawm HPMC

HPMC yog ib tug semi-synthetic polymer uas yog muab los ntawm cellulose. Nws muaj ib tug xov tooj ntawm cov khoom uas ua rau nws haum rau siv nyob rau hauv veterinary tshuaj. Cov khoom no muaj xws li:

Dej solubility: HPMC yog cov dej-soluble heev, uas txhais tau hais tias nws tuaj yeem yooj yim yaj hauv dej thiab lwm yam kev daws teeb meem aqueous. Qhov no ua rau nws yooj yim los muab tso rau hauv cov tshuaj veterinary.

Pseudo-yas tus cwj pwm: HPMC nthuav tawm tus cwj pwm pseudo-yas, uas txhais tau hais tias nws yog thixotropic thiab shear-thinning. Cov cuab yeej no tso cai rau nws txo qis viscosity ntawm kev ncua thaum raug kev nyuaj siab shear, uas ua rau nws yooj yim rau kev tswj cov tshuaj veterinary.

Kev muaj peev xwm ua yeeb yaj kiab: HPMC muaj peev xwm ua yeeb yaj kiab zoo, uas txhais tau hais tias nws tuaj yeem tsim cov txheej txheem tiv thaiv ntawm cov khoom siv tshuaj tua tsiaj, uas pab tiv thaiv lawv ntawm kev puas tsuaj thiab kev sib sau ua ke.

Mucoadhesive zog: HPMC muaj mucoadhesive zog, uas txhais tau hais tias nws muaj peev xwm ua raws li cov mucosal nto hauv lub cev. Cov cuab yeej no muaj txiaj ntsig tshwj xeeb rau lub qhov ncauj thiab qhov ntswg xa tshuaj, vim nws tso cai rau lub sijhawm sib cuag nrog cov mucosal nto thiab txhim kho kev nqus tshuaj.

Kev siv HPMC hauv Veterinary Medicine

HPMC yog siv nyob rau hauv ntau yam tshuaj veterinary. Qee qhov kev siv ntau tshaj ntawm HPMC hauv cov kws kho tsiaj muaj xws li:

Stabilization: HPMC yog siv los txhim kho kev ruaj ntseg ntawm cov kws kho tsiaj. Nws tuaj yeem pab tiv thaiv particle aggregation, flocculation, thiab sedimentation, uas tuaj yeem txhim kho lub txee lub neej ntawm cov tshuaj.

Kev hloov kho Rheological: HPMC tuaj yeem siv los hloov kho cov khoom rheological ntawm cov kws kho tsiaj. Nws tuaj yeem pab txo cov viscosity ntawm cov tshuaj, uas tuaj yeem ua kom yooj yim rau kev tswj hwm.

Tswj kev tso tawm: HPMC tuaj yeem siv los ua kom tiav cov tshuaj tso tawm los ntawm cov kws kho tsiaj. Lub peev xwm ua yeeb yaj kiab ntawm HPMC tso cai rau nws los tsim cov txheej txheem tiv thaiv ntawm qhov chaw ntawm cov tshuaj, uas tuaj yeem ua rau qeeb tso tshuaj rau hauv lub cev.

Kev txhim kho bioavailability: HPMC tuaj yeem txhim kho bioavailability ntawm cov tshuaj hauv cov tshuaj kho tsiaj. Cov khoom mucoadhesive ntawm HPMC tso cai rau nws ua raws li qhov chaw mucosal hauv lub cev, uas tuaj yeem txhim kho kev nqus tshuaj thiab bioavailability.

Saj masking: HPMC tuaj yeem siv los npog qhov tsis zoo ntawm cov tshuaj hauv cov tshuaj kho tsiaj. Qhov no yog tshwj xeeb tshaj yog muaj txiaj ntsig zoo rau cov tshuaj hauv qhov ncauj, vim nws tuaj yeem ua rau cov tshuaj ntau palatable thiab yooj yim rau kev tswj hwm tsiaj.

Cov tshuaj pleev ib ce: HPMC kuj tseem siv rau hauv cov tshuaj pleev ib ce rau cov kws kho tsiaj. Nws tuaj yeem siv ua cov thickener, stabilizer, thiab emulsifier hauv cream, tshuaj pleev, thiab gels. Tus cwj pwm pseudo-yas ntawm HPMC tso cai rau nws los txhim kho kev sib kis thiab sib xws ntawm cov tshuaj pleev ib ce.

Cov tshuaj txhaj tshuaj: HPMC kuj tuaj yeem siv rau hauv cov tshuaj txhaj tshuaj rau cov kws kho tsiaj. Nws tuaj yeem siv los ua tus neeg sawv cev ncua thiab viscosity enhancer los txhim kho kev ruaj ntseg thiab rheological zog ntawm kev txhaj tshuaj.

Xaus

Hauv kev xaus, HPMC yog ntau yam polymer uas tau siv dav hauv kev lag luam tshuaj, suav nrog hauv cov tshuaj kho tsiaj. Nws cov dej solubility, pseudo-yas tus cwj pwm, zaj duab xis-tsim muaj peev xwm, mucoadhesive zog, thiab saj masking peev xwm ua rau nws muaj txiaj ntsig muaj txiaj ntsig hauv kev tsim cov tshuaj kho tsiaj. HPMC tuaj yeem txhim kho kev ruaj ntseg, rheological zog, bioavailability, thiab palatability ntawm veterinary tshuaj, ua rau lawv yooj yim los tswj thiab zoo dua nyob rau hauv kev kho tsiaj.