HPMC rau Tshuaj

HPMCrau tshuajtau dhau los ua ib qho loj tshaj plaws ntawmkho mob thiabtshuaj excipients nyob rau hauv tsev thiab txawv teb chaws, vim hais tias HPMC rau cov tshuaj muaj qhov zoo uas lwm yam excipients tsis muaj.

1. Dej solubility

HPMC rau cov tshuaj yog soluble hauv dej txias hauv qab 40 ℃ lossis 70% ethanol. Nws yog qhov yooj yim insoluble hauv dej kub siab tshaj 60 ℃, tab sis nws tuaj yeem gelated.

2. Tshuaj inertia

HPMC rau cov tshuaj belongs rau lub non-ionic cellulose ether, nws cov tshuaj tsis muaj ionic nqi thiab hlau ntsev los yog ionic organic tebchaw, yog li nyob rau hauv kev npaj ntawm ntau lawm txheej txheem, lwm yam excipients tsis hnov ​​mob nrog nws.

3. Kev ruaj ntseg

Nws ruaj khov rau cov kua qaub thiab lub hauv paus, thiab tuaj yeem khaws cia hauv thaj tsam ntawm PH 3 ~ 11 rau lub sijhawm ntev yam tsis muaj kev hloov pauv hauv viscosity. HPMC aqueous tov muaj mildew kuj thiab muaj peev xwm ua kom zoo viscosity stability nyob rau hauv lub sij hawm ntev cia. Pharmaceutical excipients siv HPMC rau cov tshuaj, nws zoo stability dua li kev siv cov tshuaj excipients (xws li dextrin, starch, thiab lwm yam) yog zoo dua.

4. Adjustable viscosity

HPMC derivatives ntawm cov viscosity sib txawv tuaj yeem ua tau raws li qhov sib txawv, nws cov viscosity tuaj yeem hloov pauv raws li qee txoj cai, thiab muaj kev sib raug zoo linear, yog li nws tuaj yeem xaiv raws li qhov xav tau ntawm qhov sib piv. 2. 5 metabolic inertia HPMC tsis absorbed nyob rau hauv lub cev yog tsis metabolized, tsis muab tshav kub, yog li nws yog ib tug ruaj ntseg tshuaj npaj excipients. .

5. Kev ruaj ntseg

HPMCrau tshuajfeem ntau suav hais tias yog cov khoom tsis muaj tshuaj lom thiab tsis ua rau khaus.

Hydroxypropyl methyl cellulose (HPMC) yog ib qhocelluloseether tsim los ntawm cov tshuaj tiv thaiv ntawm chloromethane thiab propylene oxide nrog cov cellulose yooj yim. Dawb los yog yuav luag dawb fiber ntau los yog granular hmoov, tsw tsw. Nws tau raug siv rau hauv kev lag luam kws tshuaj rau ntau tshaj 40 xyoo, thiab tau txais kev pom zoo hauv USP19 tsab thiab Suav Pharmacopoeia 1990 tsab. Nws tau ua tiav cov txiaj ntsig zoo hauv cov khoom siv zaj duab xis txheej thiab daim ntaub nplaum.

Pharmaceutical qibHPMChydroxypropyl methyl cellulose muaj cov kev xav tau siab ntawm cov khoom siv raw, cov cuab yeej tsim khoom thiab cov khoom zoo. Nyob rau hauv xyoo tas los no, nyob rau hauv kev cuam tshuam ntawm kev nruj kev tiv thaiv ib puag ncig, qee cov chaw muag tshuaj me me hauv Suav teb sab hnub tuaj tau thim tawm ntawm kev ua lag luam, thiab qib tshuaj.HPMChydroxypropyl methyl celluloserau tshuajkev lag luam kuj tau cuam tshuam, qee qhov kev tsim khoom me me tau thim rov qab, thiab lub peev xwm concentration tau raug txhim kho.