HPMC rau zaj duab xis txheej

HPMC rauZaj duab xis txheej yog cov txheej txheem ntawm kev sib sau ua yeeb yaj kiab nyias ntawm polymer tshaj qhov kev npaj khoom. Piv txwv li, ib txheej ntawm cov ntaub ntawv ruaj khov yog txau ntawm cov ntawv yas los ntawm cov yeeb yaj kiab yas los ntawm kev txau txoj kev los txau ob peb lub microns tuab, thiaj li ua kom tiav cov nyhuv xav tau. Qhov tsim ntawm cov txheej no ntawm zaj duab xis sab nraum cov ntsiav tshuaj sab nraum cov ntsiav tshuaj yog tias ib qho khoom siv polymer tom qab cov khoom txau, thiab tom qab ntawd tau txais cov khoom siv tshuaj tsuag, thiab tom qab ntawd tau txais ib feem ntxiv ntawm cov khoom ntim tom qab ziab. Tom qab rov ua dua tshiab thiab ziab, txheej tau ua tiav kom txog thaum tag nrho cov saum npoo ntawm kev npaj yog tag nrho. Zaj duab xis txheej yog cov yeeb yaj kiab txuas ntxiv, tuab feem ntau nyob nruab nrab ntawm 8 txog 100 microns, ib qho degrons, kom paub tseeb, tightly ua raws li qhov chaw ntawm cov tub ntxhais.

Xyoo 1954, Abbott tsim thawj cov ntawv qhia ua lag luam thiab cov cuab yeej ua yeeb yaj kiab txuas ntxiv, yog li ntawd zaj duab xis txheej thev naus laus zis tau tsim kho sai. Tsis tsuas yog ntau yam, ntau thiab zoo ntawm cov xim txheej xim tau nce nrawm dua, tab sis kuj tseem yog cov khoom siv TCM tau raug tsim heev. Yog li ntawd, daim ntawv thov ntawm zaj duab xis txheej thev naus laus zis tau dhau los ua qhov kev xav tau thiab kev txhim kho ntawm cov khoom lag luam uas tsim khoom lag luam zoo.

Siv cov txheej txheem ua yeeb yaj kiab thaum ntxov ntawm cov khoom ua yeeb yaj kiab, tseem muaj ntau cov khoom siv HPMCHydroxyPropyyl Methylcelluloseraws li daim nyias nyias cov ntaub ntawv. Nws yog lub limificationHPMCCellulose los ntawm paj rwb lint los yog ntoo pulp, thiab sodium cellulethanes thiab tom qab ntawd nrog chloromethane thiab tom qab ntawd nrog cov tshuaj tua alkali thiab tom qab ntawd kom muaj cov methyl hydroxyprropyl cellulose etherHPMC, cov khoom kom tshem tawm impurities tom qab ziab, zom, ntim khoom. Feem ntau, qis viscosity HPMC yog siv los uadaim nyiasCov khoom siv txheej txheej, thiab 2% ~ 10% kev daws teeb meem yog siv raws li txheej daws. Qhov tsis zoo yog qhov viscosity yog loj dhau thiab nthuav dav yog muaj zog heev.

Lub cim thib ob ntawm zaj duab xis ua cov khoom siv yog polyvinyl cawv (PVA). Cawv cawv yog tsim los ntawm cov cawv ntawm polyvinyl acetate. Vinyl cawv Rov ua dua tsis tau cov khoom siv tsis tuaj yeem raug siv los ua reactants vim tias lawv tsis ua tiav rau cov polymerization. Hauv methanol lossis ethanol lossis ethanol thiab methyl acette tov nrog alkali hlau lossis inorganic acid li catalanyst, hydrolysis yog sai.

PVA yog dav siv nyob rau hauv zaj duab xis txheej. Vim tias nws yog insoluble hauv dej ntawm chav tsev kub, nws feem ntau coated nrog txog 20% ​​dej dispersion. Cov dej vapor thiab cov pa oxygen pva ntawm PVA qis dua HPMC thiab EC, yog li cov pa thaiv muaj zog, uas tuaj yeem tiv thaiv lub nti me me.

Kev siv yas yog hais txog cov khoom siv uas tuaj yeem ua rau cov plasticity ua kom cov ntaub ntawv. Qee cov yeeb yaj kiab sib sau ua cov ntaub ntawv hloov lawv lub cev tom qab qhov kub thiab txias tau txo qis, thiab qhov tsis muaj zog, thiab tsis yooj yim tawg. Kev siv roj hmab tau ntxiv los txo cov cua kub hloov pauv (TG) thiab nce cov txheej sib dhos. Cov yas siv tau yog amorphous polymers nrog cov molecular hnyav thiab muaj zog affinity nrog cov ntaub ntawv ua yeeb yam. Lub insoluble plastizer pab txo cov permeability ntawm txheej, yog li nce kev ruaj khov ntawm kev npaj.

Nws yog feem ntau ntseeg hais tias kev siv tshuab ntawm cov yas tshuab raj yog cov yas ntim rau hauv cov saw polymer, uas thaiv cov kev sib cuam tshuam ntawm polymer lwg me me. Qhov kev sib cuam tshuam tau yooj yim dua thaum lub polymer-planizer kev cuam tshuam yog muaj zog dua li cov polymer-planizer cuam tshuam. Yog li, cov tsam thawj rau cov ntu polymer mus tawm yog nce.

Lub Cim Thib Peb Cov Khoom Siv Ua Si yog cov yas yas los ntawm cov qauv tshuaj lom rau hauv zaj duab xis ua cov ntaub ntawv polymer

Piv txwv li, lub adventive zaj duab xis tsim cov khoom lag luam kolicoat® Ir Tshawb nrhiav cov saw ntev ntawm PVA cov hlua khi, yog li nws tuaj yeem zam kev tsiv teb chaws ntawm lub pas dej tom qab txheej