1. Taw qhia
Hauv kev lag luam kws tshuaj, kev tswj cov tshuaj tso tawm thiab kev ruaj ntseg tshuaj yog ib txoj haujlwm tseem ceeb hauv kev tsim tshuaj. Hydroxypropyl Methylcellulose (HPMC) cellulose ether yog cov khoom siv ntau yam polymer uas tau siv dav hauv cov tshuaj formulations. HPMC tau dhau los ua ib feem tseem ceeb ntawm ntau cov khoom siv thiab cov khoom siv semisolid vim nws lub cev thiab tshuaj lom neeg tshwj xeeb, tshwj xeeb tshaj yog nws cov dej tuav tau zoo.
2. Cov qauv thiab cov khoom ntawm HPMC
HPMC yog cov dej-soluble polymer compound tau los ntawm methylating thiab hydroxypropylating cellulose. Nws cov qauv molecular muaj ib lub cev pob txha cellulose thiab randomly faib methoxy (-OCH₃) thiab hydroxypropoxy (-OCH₂CHOHCH₃) hloov pauv uas muab HPMC qhov sib npaug ntawm hydrophilicity thiab hydrophobicity, ua kom nws tsim cov kua dej khov lossis gel hauv dej. Cov cuab yeej no tseem ceeb tshwj xeeb hauv kev tsim tshuaj vim tias nws pab tswj qhov tso tawm thiab ruaj khov ntawm cov tshuaj.
3. HPMC cov dej tuav mechanism
HPMC cov dej tuav yog feem ntau vim nws muaj peev xwm nqus dej, o thiab tsim cov gels. Thaum HPMC nyob rau hauv ib qho chaw aqueous, pawg hydroxyl thiab ethoxy hauv nws cov molecules cuam tshuam nrog dej molecules los ntawm hydrogen bonds, tso cai rau nws nqus dej ntau. Cov txheej txheem no ua rau HPMC o thiab tsim cov viscoelastic gel heev. Cov gel no tuaj yeem tsim txheej txheej thaiv hauv cov tshuaj formulations, yog li tswj kev sib cais thiab tso tawm tus nqi ntawm cov tshuaj.
Kev nqus dej thiab o: Tom qab HPMC cov molecules nqus dej hauv dej, lawv lub ntim nthuav dav thiab tsim cov kua nplaum siab lossis gel. Cov txheej txheem no yog nyob ntawm hydrogen bonding ntawm molecular chains thiab hydrophilicity ntawm cellulose skeleton. Qhov o no ua rau HPMC tuaj yeem ntes thiab khaws dej, yog li ua lub luag haujlwm hauv kev tuav dej hauv cov tshuaj tsim tawm.
Gel tsim: HPMC tsim cov gel tom qab yaj hauv dej. Cov qauv ntawm cov gel nyob ntawm cov yam ntxwv xws li qhov hnyav molecular, qib ntawm kev hloov pauv thiab kub ntawm cov tshuaj HPMC. Cov gel tuaj yeem tsim cov txheej txheem tiv thaiv ntawm cov tshuaj tiv thaiv kom tsis txhob poob dej ntau dhau, tshwj xeeb tshaj yog thaum qhov chaw sab nraud qhuav. Cov txheej txheej ntawm gel no tuaj yeem ncua kev sib cais ntawm cov tshuaj, yog li ua tiav cov txiaj ntsig tso tawm.
4. Kev siv HPMC hauv kev tsim tshuaj
HPMC yog dav siv nyob rau hauv ntau hom tshuaj noj, nrog rau cov ntsiav tshuaj, gels, cream, ophthalmic npaj thiab sustained-tso npaj.
Cov ntsiav tshuaj: Hauv cov ntsiav tshuaj formulations, HPMC feem ntau yog siv los ua ib qho kev sib khi lossis kev sib cais, thiab nws cov dej tuav tau tuaj yeem txhim kho cov solubility thiab bioavailability ntawm cov ntsiav tshuaj. Nyob rau tib lub sijhawm, HPMC tseem tuaj yeem tswj hwm tus nqi tso tawm ntawm cov tshuaj los ntawm kev tsim cov gel txheej, kom cov tshuaj maj mam tso tawm hauv lub plab zom mov, yog li ua kom lub sijhawm ntev ntawm kev siv tshuaj.
Gels thiab cream: Hauv kev npaj tshuaj pleev ib ce, cov dej khaws cia ntawm HPMC pab txhim kho cov nyhuv moisturizing ntawm kev npaj, ua rau kev nqus ntawm cov khoom xyaw rau ntawm daim tawv nqaij ruaj khov thiab kav ntev. HPMC tseem tuaj yeem ua rau kom muaj kev sib kis thiab kev nplij siab ntawm cov khoom.
Kev npaj kho qhov muag: Hauv kev npaj kho qhov muag, cov dej khaws cia thiab cov yeeb yaj kiab ua yeeb yaj kiab ntawm HPMC pab ua kom lub sijhawm nyob ntawm cov tshuaj nyob rau ntawm lub qhov muag, yog li ua kom cov bioavailability thiab kho cov nyhuv ntawm cov tshuaj.
Sustained-release npaj: HPMC yog siv los ua cov khoom siv matrix hauv kev npaj tso tawm, thiab tuaj yeem tswj cov tshuaj tso tawm los ntawm kev kho qhov tsim thiab kev sib cais ntawm cov gel txheej. Kev tuav dej ntawm HPMC ua rau muaj kev npaj tso tawm kom ruaj khov rau lub sijhawm ntev, txhim kho kev ua tau zoo ntawm cov tshuaj.
5. Qhov zoo ntawm HPMC
Raws li tus neeg saib xyuas dej khaws cia hauv cov tshuaj tsim tshuaj, HPMC muaj cov txiaj ntsig hauv qab no:
Kev tuav dej siab: HPMC tuaj yeem nqus tau thiab khaws cov dej ntau, tsim cov txheej txheem gel ruaj khov, thiab ncua kev sib cais thiab tso tawm cov tshuaj.
Zoo biocompatibility: HPMC muaj biocompatibility zoo, tsis ua rau lub cev tiv thaiv kab mob los yog toxicity, thiab yog haum rau ntau yam tshuaj formulations.
Kev ruaj ntseg: HPMC tuaj yeem tswj xyuas lub cev thiab tshuaj lom neeg ruaj khov nyob rau hauv cov pH sib txawv thiab qhov kub thiab txias, ua kom muaj kev ruaj ntseg ntev ntawm cov tshuaj formulations.
Adjustability: Los ntawm kev hloov qhov hnyav molecular thiab qib ntawm kev hloov ntawm HPMC, nws cov dej tuav thiab gel-forming peev xwm tuaj yeem hloov kho kom tau raws li qhov xav tau ntawm cov tshuaj sib txawv.
HPMC cellulose ether plays lub luag haujlwm tseem ceeb ua tus neeg saib xyuas dej hauv kev tsim tshuaj. Nws cov qauv tshwj xeeb thiab cov khoom ua kom nws nqus tau zoo thiab khaws cov dej, tsim cov gel txheej ruaj khov, thiab yog li tswj kev tso tawm thiab ruaj khov ntawm cov tshuaj. HPMC qhov kev ua tau zoo thiab muaj peev xwm tuav tau dej zoo heev ua rau nws yog ib qho tseem ceeb hauv cov qauv tshuaj niaj hnub, muab kev txhawb zog rau kev tsim tshuaj thiab kev siv tshuaj. Nyob rau hauv lub neej yav tom ntej, nrog kev txhim kho txuas ntxiv ntawm kev siv tshuaj thev naus laus zis, daim ntawv thov kev cia siab ntawm HPMC hauv cov tshuaj formulations yuav dav dua.
Lub sij hawm xa tuaj: Plaub Hlis-08-2024