Hydroxypropylmethylcellulose (HPMC) yog ib qho polymer muab los ntawm cellulose uas feem ntau siv nyob rau hauv ntau yam kev lag luam, suav nrog tshuaj, khoom noj, thiab kev tsim kho. Qhov kub thiab txias tuaj yeem cuam tshuam rau HPMC kev ua tau zoo thiab tus cwj pwm.
1. Solubility thiab dissolution:
Solubility: HPMC qhia txog qhov kub thiab txias-nyob ntawm solubility. Feem ntau, nws yog soluble hauv dej txias dua hauv dej kub. Cov cuab yeej no tseem ceeb heev rau cov tshuaj formulations uas yuav tsum tau tswj cov tshuaj tso tawm.
Dissolution: Tus nqi ntawm dissolution ntawm HPMC formulations cuam tshuam los ntawm kub. Kev kub siab dua feem ntau ua rau kom tawg sai dua, yog li cuam tshuam rau cov tshuaj tso tawm kinetics hauv kev siv tshuaj.
2. Gelation thiab viscosity:
gelation: HPMC tuaj yeem tsim cov gel hauv cov kua dej, thiab cov txheej txheem gelation cuam tshuam los ntawm qhov kub thiab txias. Gelation feem ntau yog nce ntawm qhov kub thiab txias, uas ua rau muaj kev ruaj ntseg gel network.
Viscosity: Kub ua lub luag haujlwm tseem ceeb hauv kev txiav txim siab viscosity ntawm HPMC cov kev daws teeb meem. Feem ntau hais lus, qhov kub thiab txias ua rau txo qis viscosity. Cov cuab yeej no tseem ceeb heev rau kev tsim cov txheej txheej, cov nplaum thiab lwm yam kev siv uas xav tau kev tswj viscosity.
3. Zaj duab xis tsim:
Zaj duab xis txheej: Hauv kev lag luam kws tshuaj, HPMC tau siv dav rau cov txheej txheem ntawm cov ntsiav tshuaj. Qhov kub thiab txias cuam tshuam rau cov yeeb yaj kiab tsim cov khoom ntawm HPMC cov kev daws teeb meem. Kev kub siab dua tuaj yeem txhim kho cov txheej txheem ua cov yeeb yaj kiab thiab cuam tshuam rau qhov zoo thiab cov yam ntxwv ntawm cov txheej txheem zaj duab xis.
4. Thermal stability:
Degradation: HPMC nthuav tawm thermal stability nyob rau hauv ib tug tej yam kub kub. Tshaj li qhov no, thermal degradation tuaj yeem tshwm sim, ua rau poob ntawm viscosity thiab lwm yam khoom xav tau. Thermal stability ntawm HPMC yuav tsum tau txiav txim siab nyob rau hauv ntau yam kev siv.
5. Theem hloov:
Iav Transition Temperature (Tg): HPMC tau hloov pauv iav ntawm qhov kub tshwj xeeb hu ua iav hloov kub (Tg). Saum toj no Tg, cov polymer hloov ntawm lub iav mus rau lub xeev rubbery, cuam tshuam rau nws cov khoom siv kho tshuab.
6. Tshuaj-Polymer Interactions:
Complex Formation: Nyob rau hauv cov tshuaj formulations, kub muaj feem xyuam rau kev sib cuam tshuam ntawm HPMC thiab cov tshuaj. Kev hloov ntawm qhov kub thiab txias tuaj yeem ua rau tsim cov complexes, cuam tshuam rau cov tshuaj solubility thiab tso tawm.
7. Formula stability:
Freeze-Thaw Stability: HPMC feem ntau yog siv rau hauv cov qauv khov, xws li cov khoom qab zib khov. Nws ruaj khov thaum lub caij khov-thaw yog cuam tshuam los ntawm kev hloov kub. Kev nkag siab txog qhov cuam tshuam ntawm qhov kub thiab txias yog qhov tseem ceeb rau kev tswj cov khoom zoo.
Kub muaj qhov cuam tshuam loj rau kev solubility, dissolution, gelation, viscosity, tsim zaj duab xis, thermal stability, theem hloov, tshuaj-polymer sib cuam tshuam, thiab formulation stability ntawm HPMC. Cov kws tshawb fawb thiab cov kws tsim qauv yuav tsum ua tib zoo xav txog cov khoom ntsuas kub no thaum siv HPMC hauv ntau daim ntawv thov.
Post lub sij hawm: Jan-20-2024