Hydroxypropyl methylcellulose (HPMC) yog cov khoom siv polymer dav siv hauv kev npaj tshuaj, feem ntau yog siv los ua kom lub sijhawm tso tawm ntawm cov tshuaj. HPMC yog ib tug semi-synthetic cellulose derivative nrog dej solubility thiab film-forming zog. Los ntawm kev kho qhov hnyav molecular, concentration, viscosity thiab lwm yam khoom ntawm HPMC, qhov kev tso tawm ntawm cov tshuaj tuaj yeem tswj tau zoo, yog li ua tiav cov tshuaj tso tawm mus ntev thiab ruaj khov.
1. Cov qauv thiab tshuaj tso tawm mechanism ntawm HPMC
HPMC yog tsim los ntawm hydroxypropyl thiab methoxy hloov pauv ntawm cov qauv cellulose, thiab nws cov qauv tshuaj ua rau nws zoo o thiab ua cov yeeb yaj kiab. Thaum nyob rau hauv kev sib cuag nrog dej, HPMC sai absorbs dej thiab swells los ua ib tug gel txheej. Kev tsim ntawm cov gel txheej no yog ib qho ntawm cov txheej txheem tseem ceeb rau kev tswj cov tshuaj tso tawm. Lub xub ntiag ntawm cov gel txheej txwv tsis pub nkag mus rau hauv cov tshuaj matrix ntxiv, thiab qhov diffusion ntawm cov tshuaj yog cuam tshuam los ntawm gel txheej, yog li ncua qhov tso tawm ntawm cov tshuaj.
2. Lub luag hauj lwm ntawm HPMC nyob rau hauv kev npaj tawm-tso tawm
Hauv kev npaj-tso tawm, HPMC feem ntau yog siv los tswj-tso matrix. Cov tshuaj tau tawg los yog yaj hauv HPMC matrix, thiab thaum nws los rau hauv kev sib cuag nrog cov kua hauv plab, HPMC o thiab tsim cov gel txheej. Raws li lub sij hawm dhau mus, cov gel txheej maj mam thickens, tsim ib lub cev barrier. Cov tshuaj yuav tsum tau muab tso rau hauv qhov nruab nrab sab nraud los ntawm kev sib kis los yog matrix yaig. Nws mechanism ntawm kev ua feem ntau suav nrog ob yam hauv qab no:
Cov txheej txheem o: Tom qab HPMC los rau hauv kev sib cuag nrog dej, txheej txheej saum npoo absorbs dej thiab swells los ua viscoelastic gel txheej. Raws li lub sij hawm dhau mus, cov gel txheej maj mam nthuav mus rau sab hauv, txheej txheej txheej swells thiab tev tawm, thiab cov txheej sab hauv txuas ntxiv tsim cov gel txheej tshiab. Qhov no txuas ntxiv o thiab tsim cov txheej txheem gel tswj qhov tso tawm ntawm cov tshuaj.
Diffusion mechanism: Lub diffusion ntawm cov tshuaj los ntawm cov gel txheej yog lwm yam tseem ceeb los tswj qhov tso tawm tus nqi. Lub gel txheej ntawm HPMC ua raws li ib tug diffusion barrier, thiab cov tshuaj yuav tsum dhau los ntawm cov txheej txheem no mus txog rau hauv vitro nruab nrab. Qhov hnyav molecular, viscosity thiab concentration ntawm HPMC hauv kev npaj yuav cuam tshuam rau cov khoom ntawm gel txheej, yog li tswj cov diffusion tus nqi ntawm cov tshuaj.
3. Tej yam cuam tshuam rau HPMC
Muaj ntau yam uas cuam tshuam rau kev tswj kev tso tawm ntawm HPMC, suav nrog qhov hnyav molecular, viscosity, ntau npaum ntawm HPMC, lub cev thiab tshuaj lom neeg ntawm cov tshuaj, thiab ib puag ncig sab nraud (xws li pH thiab ionic zog).
Molecular hnyav thiab viscosity ntawm HPMC: Qhov loj dua qhov hnyav molecular ntawm HPMC, qhov viscosity ntawm cov gel txheej ntau dua thiab cov tshuaj tso tawm qeeb dua. HPMC nrog cov viscosity siab tuaj yeem tsim cov txheej txheej tawv tawv, cuam tshuam qhov sib txawv ntawm cov tshuaj, yog li ncua sijhawm tso tawm ntawm cov tshuaj. Yog li ntawd, nyob rau hauv kev tsim ntawm sustained-tso npaj, HPMC nrog sib txawv molecular luj thiab viscosities feem ntau xaiv raws li kev xav tau kom ua tiav qhov kev cia siab tso tawm.
Concentration ntawm HPMC: Qhov concentration ntawm HPMC kuj yog ib qho tseem ceeb ntawm kev tswj cov tshuaj tso tawm tus nqi. Qhov siab dua ntawm HPMC, qhov tuab ntawm cov gel txheej tsim, qhov ntau dua qhov kev tawm tsam ntawm cov tshuaj los ntawm txheej gel, thiab qhov qis dua qhov tso tawm. Los ntawm kev kho qhov ntau npaum ntawm HPMC, lub sij hawm tso tawm ntawm cov tshuaj tuaj yeem tswj tau yooj yim.
Physicochemical zog ntawm cov tshuaj: Cov dej solubility, molecular yuag, solubility, thiab lwm yam ntawm cov tshuaj yuav cuam tshuam rau nws tso tus cwj pwm nyob rau hauv lub HPMC matrix. Rau cov tshuaj uas muaj dej zoo solubility, cov tshuaj muaj peev xwm yaj nyob rau hauv dej sai sai thiab diffuse los ntawm cov gel txheej, yog li qhov tso tawm sai dua. Rau cov tshuaj uas tsis muaj dej solubility, solubility tsawg, cov tshuaj diffuses maj mam nyob rau hauv lub gel txheej, thiab lub sij hawm tso tawm yog ntev dua.
Kev cuam tshuam ntawm ib puag ncig sab nraud: Cov khoom siv gel ntawm HPMC tuaj yeem sib txawv hauv ib puag ncig nrog cov pH sib txawv thiab qhov muaj zog ionic. HPMC tuaj yeem qhia tus cwj pwm o sib txawv hauv qhov chaw acidic, yog li cuam tshuam rau cov tshuaj tso tawm. Vim yog qhov loj pH hloov nyob rau hauv tib neeg txoj hnyuv, tus cwj pwm ntawm HPMC matrix sustained-tso npaj nyob rau hauv txawv pH tej yam kev mob yuav tsum tau tshwj xeeb saib xyuas kom meej tias cov tshuaj yuav tsum tau tso tawm stably thiab tsis tu ncua.
4. Kev siv HPMC hauv ntau hom kev tswj-tso npaj
HPMC yog dav siv nyob rau hauv sustained-tso npaj ntawm ntau npaum li cas cov ntaub ntawv xws li ntsiav tshuaj, tsiav tshuaj, thiab granules. Hauv cov ntsiav tshuaj, HPMC raws li cov khoom siv matrix tuaj yeem tsim cov tshuaj sib xyaw-polymer sib xyaw thiab maj mam tso cov tshuaj hauv plab hnyuv. Hauv cov tshuaj ntsiav, HPMC kuj tseem siv tau los ua cov tshuaj tiv thaiv-tso daim nyias nyias los pleev cov tshuaj, thiab lub sijhawm tso tawm ntawm cov tshuaj yog tswj los ntawm kev kho cov thickness thiab viscosity ntawm txheej txheej.
Daim ntawv thov hauv cov ntsiav tshuaj: Cov ntsiav tshuaj yog daim ntawv qhia qhov ncauj ntau tshaj plaws, thiab HPMC feem ntau yog siv los ua kom tiav cov nyhuv tso tawm ntawm cov tshuaj. HPMC tuaj yeem sib xyaw nrog cov tshuaj thiab compressed los ua ib qho kev sib cais ntawm cov matrix. Thaum cov ntsiav tshuaj nkag mus rau hauv lub plab zom mov, qhov chaw HPMC sai sai swells thiab tsim cov gel, uas ua rau qeeb tus nqi ntawm cov tshuaj. Nyob rau tib lub sijhawm, raws li cov txheej txheem gel txuas ntxiv mus ntxiv, kev tso tawm ntawm cov tshuaj sab hauv yog maj mam tswj.
Daim ntawv thov nyob rau hauv capsules:
Hauv kev npaj tshuaj ntsiav, HPMC feem ntau yog siv los ua cov txheej txheem tso tawm. Los ntawm kev kho cov ntsiab lus ntawm HPMC nyob rau hauv lub capsule thiab lub thickness ntawm txheej zaj duab xis, qhov tso tawm ntawm cov tshuaj yuav tswj tau. Tsis tas li ntawd, HPMC muaj solubility zoo thiab biocompatibility nyob rau hauv dej, yog li nws muaj dav daim ntawv thov kev cia siab nyob rau hauv capsule tswj kev tso tawm systems.
5. Txoj kev loj hlob yav tom ntej
Nrog rau kev nce qib ntawm kev siv tshuab thev naus laus zis, daim ntawv thov ntawm HPMC tsis yog tsuas yog txwv rau kev npaj tso tawm, tab sis kuj tseem tuaj yeem ua ke nrog lwm cov tshuaj xa tawm tshiab, xws li microspheres, nanoparticles, thiab lwm yam, kom ua tiav cov tshuaj tswj tau ntau dua. Tsis tas li ntawd, los ntawm kev hloov kho cov qauv ntawm HPMC ntxiv, xws li kev sib xyaw nrog lwm cov polymers, kev hloov kho tshuaj, thiab lwm yam, nws cov kev ua tau zoo hauv kev tswj hwm-tso npaj yuav ua kom zoo dua ntxiv.
HPMC tuaj yeem ua kom ntev lub sij hawm tso tawm ntawm cov tshuaj los ntawm nws cov txheej txheem ntawm o los tsim ib txheej gel. Cov yam ntxwv xws li qhov hnyav molecular, viscosity, concentration ntawm HPMC thiab physicochemical zog ntawm cov tshuaj yuav cuam tshuam rau nws cov kev tswj kev tso tawm. Hauv kev siv tswv yim, los ntawm kev tsim qauv tsim kev siv ntawm HPMC, kev tso tawm cov tshuaj sib txawv tuaj yeem ua tiav kom tau raws li qhov xav tau ntawm kev kho mob. Nyob rau hauv lub neej yav tom ntej, HPMC muaj dav daim ntawv thov kev cia siab nyob rau hauv lub teb ntawm cov tshuaj tiv thaiv kev tso tawm, thiab tej zaum yuav ua ke nrog cov tshiab technologies los txhawb txoj kev loj hlob ntawm kev xa tshuaj.
Post lub sij hawm: Sep-19-2024