HPMC ncua kev tso tshuaj li cas?

Hydroxypropyl methylcellulose (HPMC) yog ib qho hluavtaws polymer uas tau siv dav hauv kev lag luam kws tshuaj los tswj kev tso tshuaj. Nws yog non-ionic, dej-soluble polymer uas tsim ib gel nyob rau hauv lub xub ntiag ntawm dej. HPMC yog siv los hloov kho tus nqi tso tawm ntawm cov tshuaj los ntawm cov ntaub ntawv ntau npaum li cas, xws li cov ntsiav tshuaj, tshuaj ntsiav, thiab kev ncua. Nws kuj yog siv los ua ib qho kev sib khi, disintegrant, thiab lubricant hauv kev tsim cov ntsiav tshuaj thiab tshuaj ntsiav.

HPMC ua haujlwm los ntawm kev tsim cov gel matrix nyob ib ncig ntawm cov tshuaj. Cov gel matrix no yog semi-permeable, txhais tau hais tias nws tso cai rau dej los ntawm nws, tab sis tsis yog cov tshuaj hais. Raws li cov dej dhau los ntawm cov gel matrix, nws maj mam dissolves cov tshuaj, tso lawv mus rau ib puag ncig ib puag ncig. Cov txheej txheem no yog hu ua diffusion-tswj tso tawm.

Tus nqi ntawm diffusion-tswj tso tawm tuaj yeem tswj tau los ntawm kev kho cov khoom ntawm HPMC gel matrix. Piv txwv li, qhov viscosity ntawm gel matrix tuaj yeem nce ntxiv los ntawm kev ntxiv HPMC, uas yuav ua rau qeeb tus nqi ntawm kev tso tawm-tswj. Qhov loj ntawm cov tshuaj tuaj yeem hloov kho, vim tias cov khoom me me yuav diffuse sai dua li cov khoom loj.

Ntxiv rau kev tswj hwm tus nqi tso tawm ntawm cov tshuaj, HPMC kuj muaj lwm yam khoom muaj txiaj ntsig. Nws yog non-toxic, non-irritating, thiab non-allergenic, ua rau nws muaj kev nyab xeeb siv nyob rau hauv cov tshuaj formulations. Nws kuj yog non-hygroscopic, txhais tau hais tias nws tsis nqus noo noo los ntawm ib puag ncig, uas pab tswj kev ruaj khov ntawm kev tsim.

HPMC yog ib qho cuab yeej siv tau zoo rau kev tswj cov tshuaj tso tawm. Los ntawm kev kho cov khoom ntawm HPMC gel matrix, tus nqi ntawm diffusion-tswj tso tawm tuaj yeem raug kho kom tau raws li qhov xav tau tso tawm profile. Qhov no tso cai rau kev tsim cov formulations uas tso tawm cov tshuaj ntawm tus nqi tswj nyob rau lub sij hawm ntev.