Hydroxypropyl methylcellulose (HPMC) yog ib qho tseem ceeb ntawm cov dej-soluble polymer uas tau siv dav hauv kev tsim kho, tshuaj, zaub mov thiab tshuaj pleev ib ce kev lag luam, tshwj xeeb tshaj yog nyob rau hauv daim ntawv nplaum. Kev tswj viscosity ntawm HPMC yog qhov tseem ceeb rau cov khoom lag luam. tseem ceeb. Kev txhim kho cov viscosity ntawm HPMC hauv cov nplaum tuaj yeem ua tiav los ntawm kev kho nws lub cev thiab tshuaj lom neeg, nrog rau kev ua kom zoo rau kev tsim thiab kev siv ib puag ncig.
1. Kho qhov hnyav molecular ntawm HPMC
Lub viscosity ntawm HPMC feem ntau yog nyob ntawm nws qhov hnyav molecular. Feem ntau hais lus, qhov hnyav dua molecular, qhov viscosity siab dua. Los ntawm kev xaiv HPMC nrog qhov hnyav molecular, qhov viscosity ntawm cov nplaum tuaj yeem tswj tau zoo. Feem ntau, HPMC nrog qhov hnyav dua molecular yuav ua rau kom cov viscosity ntawm cov nplaum, tab sis nws tseem yuav cuam tshuam rau kev khiav thiab kev ua haujlwm. Yog li ntawd, qhov sib npaug ntawm viscosity thiab operability yuav tsum tau pom nyob rau hauv cov ntaub ntawv siv.
2. Tswj cov qib hloov ntawm HPMC
HPMC yog ib yam khoom tau los ntawm methylcellulose los ntawm ib nrab hydroxypropylation cov tshuaj tiv thaiv. Nws qib ntawm kev hloov pauv (uas yog, qib ntawm kev hloov pauv ntawm hydroxypropyl thiab methyl pawg) muaj qhov cuam tshuam loj rau viscosity. Cov qib siab dua ntawm kev hloov pauv feem ntau txo qhov viscosity ntawm HPMC, thaum qis dua ntawm kev hloov pauv nce viscosity. Yog li, los ntawm kev kho cov qib ntawm kev hloov pauv ntawm HPMC, kev tswj tau zoo ntawm viscosity tuaj yeem ua tiav. Hauv cov xwm txheej sib txawv, HPMC nrog rau qib sib txawv ntawm kev hloov pauv yuav xav tau kom ua tau raws li qhov yuav tsum tau ua ntawm cov nplaum.
3. Kev tswj qhov kub thiab txias
Lub solubility thiab viscosity ntawm HPMC yog ze ze rau qhov kub thiab txias. Feem ntau hais lus, HPMC muaj viscosity ntau dua thaum yaj ntawm qhov kub thiab txias. Los ntawm optimizing qhov kub dissolution ntawm HPMC thaum lub sij hawm npaj cov nplaum, cov viscosity ntawm cov khoom kawg tuaj yeem hloov kho. Piv txwv li, dissolving HPMC ntawm qhov kub thiab txias tuaj yeem ua rau qis qis qis, tab sis maj mam nce hauv viscosity raws li qhov kub thiab txias. Yog li ntawd, los ntawm kev tswj qhov kub thiab txias thaum lub sij hawm tsim kho, dynamic hloov ntawm viscosity tuaj yeem ua tiav.
4. Ntxiv thickener
Hauv HPMC cov nplaum nplaum, ntxiv qhov tsim nyog ntawm cov thickener tuaj yeem ua kom cov viscosity zoo. Cov thickeners feem ntau suav nrog xanthan gum, carbomer, cellulose derivatives, thiab lwm yam. Cov thickeners no ua haujlwm nrog HPMC los txhim kho tag nrho cov viscosity ntawm cov nplaum. Tsis tas li ntawd, cov thickeners tuaj yeem txhim kho kev ruaj ntseg thiab sag tsis kam ntawm cov nplaum, muab nws ua haujlwm zoo dua hauv daim ntawv thov.
5. Kho cov tshuaj concentration ntawm HPMC
Qhov concentration ntawm HPMC cov tshuaj hauv dej muaj qhov cuam tshuam ncaj qha rau cov viscosity. Qhov siab dua qhov concentration, qhov viscosity ntau dua. Hauv kev siv cov tswv yim, cov viscosity ntawm cov nplaum tuaj yeem hloov kho tau yooj yim los ntawm kev tswj hwm qhov kev daws teeb meem ntawm HPMC. Piv txwv li, thaum npaj cov nplaum, cov viscosity tuaj yeem nce ntxiv los ntawm kev maj mam nce tus nqi ntawm HPMC, lossis cov viscosity tuaj yeem txo los ntawm diluting.
6. Daim ntawv qhia optimization
Lub viscosity ntawm HPMC nplaum tsis tsuas yog nyob ntawm tus yam ntxwv ntawm HPMC nws tus kheej, tab sis kuj yog ze ze rau tag nrho cov txheej txheem tsim. Los ntawm optimizing hom thiab proportions ntawm lwm yam Cheebtsam nyob rau hauv lub mis, xws li muab tub lim, co-solvents, stabilizers, thiab lwm yam., lub viscosity yuav kho tau zoo. Piv txwv li, ua kom tus nqi ntawm cov muab tub lim kom tsim nyog tuaj yeem ua rau kom cov viscosity nce, tab sis ntau qhov muab tub lim yuav ua rau cov nplaum tsis muaj dej tsis zoo thiab ua rau nws nyuaj rau kev thov. Yog li, tsim qauv qauv tsim nyog yog tus yuam sij rau kev txhim kho cov viscosity ntawm HPMC.
7. Kev hloov kho ntawm tus nqi pH
Lub viscosity ntawm HPMC kuj cuam tshuam los ntawm pH ntawm cov tshuaj. Hauv qee qhov ntau, qhov viscosity ntawm HPMC hloov nrog pH tus nqi. Feem ntau, HPMC nthuav tawm cov viscosity siab dua hauv nruab nrab rau qhov tsis muaj zog alkaline ib puag ncig, thaum nyob rau hauv cov kua qaub lossis alkaline, cov viscosity yuav txo qis heev. Yog li ntawd, los ntawm kev kho cov pH ntawm cov nplaum, kev tswj cov viscosity tuaj yeem ua tiav. Piv txwv li, hauv qee daim ntawv thov, pH tuaj yeem ruaj khov los ntawm kev ntxiv buffers kom muaj qhov ruaj khov viscosity.
8. Siv cov neeg sawv cev sib txuas
Qee qhov xwm txheej, qhov sib ntxiv ntawm cov neeg sawv cev sib txuas tuaj yeem ua rau muaj qhov viscosity ntawm HPMC. Cov kab sib txuas sib txuas tuaj yeem tsim kev sib txuas ntawm lub cev lossis tshuaj lom neeg sib txuas ntawm HPMC cov molecules thiab txhim kho kev sib cuam tshuam ntawm cov saw hlau molecular, yog li ua kom cov viscosity nce. Piv txwv li, hauv kev tsim cov nplaum nplaum, kev sib txuas ntawm HPMC tuaj yeem raug ntxias los ntawm kev ntxiv qhov tsim nyog ntawm boric acid lossis lwm yam ions ntau ntau kom tau txais cov nplaum nplaum siab.
9. Kev tswj kub thiab av noo
Hauv kev siv tswv yim, viscosity ntawm HPMC nplaum kuj cuam tshuam los ntawm qhov kub thiab txias. Qhov kub thiab txias feem ntau txo qhov viscosity ntawm HPMC, thaum nce av noo tuaj yeem ua rau cov viscosity hloov pauv hauv cov nplaum. Yog li ntawd, kev tswj xyuas qhov kub thiab av noo ntawm qhov chaw tsim kho tuaj yeem pab tswj cov viscosity zoo tshaj plaws ntawm HPMC nplaum.
10. Kev ua kom zoo ntawm cov xwm txheej cia
Cia tej yam kev mob ntawm HPMC adhesives muaj kev cuam tshuam ntev rau viscosity. Txhawm rau kom muaj viscosity ruaj khov, cov nplaum yuav tsum tau muab cia rau hauv qhov chaw qhuav, txias, tsis txhob muaj qhov kub thiab txias. Tsis tas li ntawd, lub sijhawm khaws cia ntev yuav ua rau txo qis viscosity. Yog li ntawd, tsis tu ncua xyuas cov viscosity ntawm cov nplaum thiab ua kev hloov kho raws li qhov tsim nyog kuj tseem ceeb rau kev ntsuas qhov zoo ntawm cov nplaum.
Post lub sij hawm: Sep-03-2024