Cov yam ntxwv cuam tshuam rau viscosity ntawm hydroxypropyl methylcellulose

Hydroxyl methyl cellulose (HPMC) yog cov khoom siv polymer dav siv hauv tshuaj, tshuaj pleev ib ce, zaub mov thiab lwm yam lag luam. Nws cov yam ntxwv tshwj xeeb, xws li siab viscosity, dej zoo-soluble thiab membrane tsim muaj peev xwm, ua rau nws yog ib qho tseem ceeb hauv ntau hom qauv. Lub viscosity yog qhov tseem ceeb ntawm HPMC hauv nws daim ntawv thov. HPMC's viscosity yog cuam tshuam los ntawm ntau yam, xws li concentration, kub, pH, thiab molecular hnyav. Nkag siab txog yam cuam tshuam rau HPMC viscosity yog qhov tseem ceeb rau kev ua kom zoo. Kab lus no tham txog yam cuam tshuam rau viscosity ntawm hydroxylopyl methyl cellulose.

Tsom ntsoov rau

Qhov concentration ntawm HPMC yog ib qho ntawm cov tseem ceeb uas cuam tshuam rau nws cov viscosity. Lub viscosity ntawm cov tshuaj HPMC nce nrog qhov nce ntawm concentration. Ntawm qhov qis dua, HPMC cov saw hlau polymer yog dav tawg nyob rau hauv cov kuab tshuaj, yog li cov viscosity tsawg. Txawm li cas los xij, ntawm qhov siab dua, cov saw hlau polymer feem ntau cuam tshuam nrog ib leeg, ua rau muaj viscosity ntau dua. Yog li ntawd, lub viscosity ntawm HPMC yog proportional rau lub concentration ntawm polymer. Qhov concentration kuj cuam tshuam rau HPMC tus cwj pwm gelization. High-concentration HPMC tuaj yeem tsim cov gel, uas tseem ceeb heev hauv kev lag luam tshuaj thiab zaub mov.

kub

Kub yog lwm qhov tseem ceeb cuam tshuam rau viscosity ntawm hydroxylopenyl cellulose. HPMC lub viscosity txo nrog qhov kub nce. HPMC polymer saw ua ntau ntws ntawm qhov kub thiab txias, ua rau muaj viscosity tsawg. Piv nrog rau cov kev daws teeb meem siab, cov nyhuv ntawm qhov kub thiab txias ntawm HPMC viscosity yog qhov pom tseeb dua hauv cov tshuaj tsis tshua muaj siab. Qhov nce hauv qhov kub thiab txias yuav cuam tshuam rau kev solubility ntawm HPMC. Ntawm qhov kub siab dua, qhov solubility ntawm HPMC txo qis, ua rau txo qis hauv viscosity tshwm sim los ntawm kev txo qis hauv cov saw txuas.

pH

Lub pH ntawm HPMC cov tshuaj yog lwm qhov tseem ceeb cuam tshuam rau nws cov viscosity. HPMC yog ib qho tsis muaj zog acidic polymer, nrog PKA txog li 3.5. Yog li, qhov viscosity ntawm HPMC cov tshuaj yog rhiab rau pH ntawm cov tshuaj. Raws li tus nqi pH siab dua PKA, cov carboxylic acid ntsev pawg ntawm cov polymer tau raug protonization, uas ua rau cov solubility ntawm HPMC nce, thiab cov viscosity raug txo vim qhov txo qis hauv hydrogen bonds ntawm molecular interconsiscence. Raws li tus nqi pH hauv qab PKA, pawg carboxylic acid ntawm cov polymer yog loj, uas ua rau tsis tshua muaj solubility thiab siab viscosity tshwm sim los ntawm kev nce hydrogen bonds. Yog li ntawd, tus nqi pH zoo tshaj plaws ntawm HPMC cov tshuaj yog nyob ntawm daim ntawv thov xav tau.

Molecular hnyav

HPMC qhov hnyav molecular yog lwm qhov tseem ceeb uas cuam tshuam rau nws cov viscosity. HPMC yog ib qho polymer polymer. Raws li qhov hnyav molecular ntawm cov polymer nce, viscosity ntawm HPMC cov tshuaj yuav nce. Qhov no yog vim hais tias lub siab molecular hnyav HPMC saw yog ntau entangled, ua rau muaj zog viscosity. Qhov hnyav molecular ntawm cov polymer kuj cuam tshuam rau HPMC gelization. HPMC polymer feem ntau yuav tsim cov gels dua li qhov hnyav molecular polymers.

Ntsev

Ntxiv ntsev rau cov tshuaj HPMC tuaj yeem cuam tshuam rau nws cov viscosity. Cov ntsev cuam tshuam rau lub zog ion ntawm HPMC cov tshuaj, uas hloov cov kev cuam tshuam ntawm cov polymers. Feem ntau, ntxiv ntsev rau HPMC cov tshuaj yuav ua rau viscosity txo. Qhov no yog vim lub zog ion ntawm cov tshuaj txo qis ntawm cov molecular quab yuam ntawm HPMC polymer saw, yog li txo qis ntawm cov saw entanglement, yog li cov viscosity txo. Cov nyhuv ntawm ntsev ntawm viscosity ntawm HPMC cov tshuaj nyob ntawm seb hom thiab concentration ntawm ntsev.

nyob rau hauv xaus

Lub viscosity ntawm hydroxydal cibolin yog ib qho tseem ceeb parameter uas cuam tshuam rau nws daim ntawv thov nyob rau hauv ntau yam lag luam. Cov yam ntxwv cuam tshuam rau HPMC viscosity muaj xws li concentration, kub, pH, molecular hnyav thiab ntsev. Kev nkag siab txog cov xwm txheej no ntawm HPMC viscosity yog qhov tseem ceeb los txhim kho nws txoj kev siv hauv ntau daim ntawv thov. Cov tshuaj HPMC tuaj yeem hloov kho kom tsim nyog kom ua tiav qhov xav tau viscosity uas yog qhov tshwj xeeb.