Cellulose ethers yog ib chav kawm ntawm kev hloov pauv polymers raws li cellulose, uas tau siv dav hauv kev lag luam tshuaj vim lawv lub cev zoo thiab tshuaj lom neeg. Nws hom tseem ceeb suav nrog hydroxypropyl methylcellulose (HPMC), carboxymethyl cellulose (CMC) thiab methyl cellulose (MC). Cov cellulose ethers no muaj ntau yam kev siv nyob rau hauv cov chaw muag tshuaj, npog cov ntsiav tshuaj, tshuaj ntsiav, sustained-tso npaj thiab npaj ua kua.
1. Daim ntawv thov hauv cov ntsiav tshuaj thiab tshuaj ntsiav
Hauv cov ntsiav tshuaj thiab tshuaj ntsiav tshuaj, cellulose ethers feem ntau yog siv los ua binders, disintegrants thiab txheej txheej. Raws li binders, lawv tuaj yeem txhim kho qhov adhesion ntawm cov khoom siv tshuaj, kom cov ntsiav tshuaj tsim cov qauv tsim nyog nrog lub sijhawm hardness thiab tawg. Cellulose ethers kuj tseem tuaj yeem txhim kho cov fluidity thiab compressibility ntawm cov tshuaj thiab txhawb kev molding zoo.
Binders: Piv txwv li, HPMC raws li ib tug binder muaj peev xwm muab sib npaug zos rau saum npoo ntawm cov tshuaj hais, muab ib tug zoo adhesion los xyuas kom meej tias cov ntsiav tshuaj muaj ib tug ruaj khov zoo thaum lub sij hawm compression.
Disintegrants: Thaum cellulose ethers swell nyob rau hauv dej, lawv muaj peev xwm ua tau kom lub disintegration tus nqi ntawm cov ntsiav tshuaj thiab xyuas kom meej tso tawm sai sai ntawm cov tshuaj. MC thiab CMC, raws li cov disintegrants, tuaj yeem ua kom cov ntsiav tshuaj tawg hauv lub plab zom mov thiab txhim kho bioavailability ntawm cov tshuaj los ntawm lawv cov hydrophilicity thiab o cov khoom.
Cov ntaub ntawv txheej: Cellulose ethers xws li HPMC kuj tau siv rau txheej ntsiav tshuaj thiab tshuaj ntsiav. Cov txheej txheej tsis tuaj yeem tsuas npog qhov tsis zoo ntawm cov tshuaj, tab sis kuj muab cov txheej txheem tiv thaiv kom txo tau qhov cuam tshuam ntawm ib puag ncig cov av noo ntawm cov tshuaj stability.
2. Daim ntawv thov nyob rau hauv kev npaj tso tawm
Cellulose ethers ua lub luag haujlwm tseem ceeb hauv kev npaj tawm-tso tawm thiab feem ntau yog siv los tswj cov tshuaj tso tawm. Los ntawm kev kho hom, viscosity thiab concentration ntawm cellulose ethers, cov kws muag tshuaj tuaj yeem tsim cov tshuaj sib txawv tso tawm nkhaus kom ua tiav kev tso tawm qeeb, tswj kev tso tawm lossis kev tso tawm.
Cov tshuaj tiv thaiv kev tso tawm: Cellulose ethers xws li HPMC thiab EC (ethyl cellulose) yog siv los tswj cov tshuaj tso tawm hauv cov ntsiav tshuaj uas tau tso tawm. Lawv tuaj yeem maj mam yaj hauv lub cev los tsim cov txheej txheem gel, yog li tswj hwm qhov tso tawm ntawm cov tshuaj thiab tswj cov ntshav plasma concentration ntawm cov tshuaj.
Cov ntaub ntawv pob txha: Hauv cov pob txha pob txha-tso tawm kev npaj, cellulose ethers disperse cov tshuaj nyob rau hauv matrix los ntawm kev tsim ib tug network qauv los kho tus nqi dissolution ntawm cov tshuaj. Piv txwv li, HPMC cov ntaub ntawv pob txha tsim cov gels thaum raug dej, tiv thaiv cov tshuaj yaj sai sai thiab ua tiav kev tswj xyuas mus ntev.
3. Daim ntawv thov hauv kev npaj ua kua
Cellulose ethers yog dav siv los ua cov thickeners, tshem tawm cov neeg ua haujlwm thiab stabilizers hauv cov kua npaj. Lawv tuaj yeem ua kom cov viscosity thiab ruaj khov ntawm cov kua npaj thiab tiv thaiv cov tshuaj los ntawm kev sib haum xeeb lossis stratifying thaum khaws cia.
Thickeners: Cellulose ethers (xws li CMC) raws li cov thickeners tuaj yeem ua kom cov viscosity ntawm kev npaj ua kua, ua kom cov khoom sib xyaw ntawm cov tshuaj sib xyaw, thiab tiv thaiv cov dej nag.
Suspending agents: HPMC thiab MC yog siv los ua cov tshuaj tshem tawm hauv kev npaj ua kua los xyuas kom meej tias cov khoom raug tshem tawm tau muab faib ua tusyees thoob plaws qhov kev npaj los ntawm kev tsim cov kab ke ruaj khov colloidal los tiv thaiv kev sib cais ntawm cov khoom xyaw tshuaj.
Stabilizers: Cellulose ethers kuj tseem siv tau los ua cov stabilizers los txhim kho cov tshuaj lom neeg thiab lub cev ruaj khov ntawm cov kua npaj thaum lub sijhawm khaws cia thiab txuas ntxiv lub txee lub neej ntawm cov tshuaj.
4. Lwm yam kev siv
Tsis tas li ntawd, cellulose ethers kuj tau siv rau hauv kev npaj transdermal thiab ophthalmic npaj hauv kev lag luam kws tshuaj. Lawv ua raws li cov yeeb yaj kiab yav dhau los thiab cov viscosity enhancers hauv cov ntawv thov no los txhim kho cov adhesion thiab bioavailability ntawm kev npaj.
Transdermal npaj: HPMC thiab CMC feem ntau yog siv los ua zaj duab xis yav dhau los rau cov kab mob sib kis, uas txhim kho qhov kev nqus ntawm cov tshuaj los ntawm kev tswj cov evaporation ntawm dej thiab nkag mus rau cov tshuaj.
Kev npaj kho qhov muag: Hauv kev npaj kho qhov muag, cellulose ethers yog siv los ua cov thickeners los txhim kho cov adhesion ntawm cov tshuaj ophthalmic, ncua sij hawm nyob ntawm cov tshuaj nyob rau ntawm lub qhov muag, thiab txhim kho cov nyhuv kho.
Kev siv dav ntawm cellulose ethers hauv kev lag luam kws tshuaj yog los ntawm lawv cov khoom zoo ntawm lub cev thiab tshuaj lom neeg, xws li biocompatibility zoo, tswj tau solubility thiab versatility kom tau raws li cov kev xav tau ntawm kev npaj sib txawv. Los ntawm kev xaiv thiab ua kom zoo ntawm cellulose ethers, cov tuam txhab tshuaj tuaj yeem txhim kho qhov zoo thiab ruaj khov ntawm kev npaj tshuaj thiab ua tau raws li cov neeg mob cov kev xav tau ntawm kev siv tshuaj nyab xeeb thiab kev ua haujlwm zoo. Nrog rau kev nce qib ntawm kev siv tshuaj thev naus laus zis tas li, daim ntawv thov kev cia siab ntawm cellulose ethers yuav dav dua.
Post lub sij hawm: Lub Xya hli ntuj-12-2024