Ua ntej, cov lus Askiv luv ntawm cov ntaub ntawv pabcuam
MC: Methyl cellulose
EC: ethyl cellulose
HPC: hydroxypropyl cellulose
HPMC: hydroxypropyl methylcellulose
CAP: Cellulose acetate phthalates
HPMCP: hydroxypropyl cellulose phthalates
HPMCAS: hydroxypropyl methyl cellulose acetate succinate
Cmc-na: Sodium carboxymethyl cellulose
MCC: Microcrystalline cellulose
PVP: Povidone
PEG: polyethylene glycol
PVA: Polyvinyl cawv
Cms-na: Sodium carboxymethyl starch
PVPP: Hla-txuas povidone
CCNa: crosslinked sodium carboxymethyl cellulose
Qhov thib ob, kev siv qee cov khoom siv pabcuam
1. Lactose: ntsiav tshuaj: muab tub lim, tshwj xeeb tshaj yog hmoov ncaj qha ntsiav tshuaj muab tub lim;Txhaj tshuaj: lyophilized tiv thaiv
2. Microcrystalline cellulose: ntsiav tshuaj: hmoov ncaj qha pressed ntsiav tshuaj muab tub lim;"Dry adhesive";Cov ntsiav tshuaj muaj 20% microcrystalline cellulose ua raws li disintegrators
3. Methyl cellulose: ntsiav tshuaj: nplaum;Suspension agent: kev pab cuam ncua kev kawm ntawv;Slow (tswj) tso tawm npaj: hydrophilic gel skeleton khoom (tsis muaj zog)
4 sodium carboxymethyl cellulose: ntsiav tshuaj: nplaum;Suspension agent: kev pab cuam ncua kev kawm ntawv;qeeb (tswj) tso tawm npaj: hydrophilic gel skeleton khoom
5. Ethyl cellulose: ntsiav tshuaj: nplaum (insoluble hauv dej);qeeb (tswj) kev npaj tso tawm: cov khoom siv pob txha lossis cov khoom siv membrane tswj;Khoom dispersion: insoluble carrier khoom
6 hydroxypropyl cellulose: ntsiav tshuaj: nplaum, zaj duab xis txheej khoom;Suspension agent: kev pab cuam ncua kev kawm ntawv;Slow (tswj) tso tawm kev npaj: hydrophilic gel skeleton khoom, microporous membrane coated ntawv pore-inducing tus neeg sawv cev
7. Hydroxypropyl methyl cellulose (hydroxypropyl methyl cellulose): ntsiav tshuaj: nplaum, zaj duab xis txheej khoom;Suspension agent: kev pab cuam ncua kev kawm ntawv;Kev npaj ua kom qeeb thiab tswj tau: hydrophilic gel skeleton khoom, microporous membrane coated ntawv pore-inducing tus neeg sawv cev
8. Cellulose acetate phthalates: enteric khoom
9. Hydroxypropyl cellulose phthalates: enteric khoom
10. Hydroxypropyl cellulose acetate succinate: enteric khoom
11. Polyvinyl phthalate (PVAP): enteric khoom
12. Styrene Maleic acid copolymer (StyMA): cov khoom siv hauv plab hnyuv soluble
13. Acrylic resin (enteric type I, II, III), Eudragit L, Eudragit S (qee zaum Eudragit L100 los yog Eudragit S 100): cov khoom siv enteric
14.Eudragit RL, Eudragit RS: : Insoluble carrier khoom
15.Eudragit E (sib npaug rau acrylic IV): gastric soluble polymer khoom
16. Cellulose acetate: dej insoluble khoom, yuav siv tau rau txheej los yog npaj ntawm osmotic twj tso kua mis ntsiav tshuaj
17. Polyvinylpyrrolidone (povidone PVP): ntsiav tshuaj: adhesives;Ntsiav tshuaj: gastric soluble zaj duab xis txheej khoom;pellets: nifedipine pellets (khoom dispersion);Suspension agent: kev pab cuam ncua kev kawm ntawv;
Khoom dispersion: dej-soluble carrier khoom;qeeb (tswj) tso tawm npaj: hydrophilic colloid skeleton khoom;Kev npaj qeeb (tswj) tso tawm: pore-inducing tus neeg sawv cev hauv microporous membrane coated ntsiav tshuaj
18. Polyvinyl cawv: zaj duab xis tus neeg sawv cev: zaj duab xis tsim cov khoom, kev pab cuam ncua
19. Sodium carboxymethyl starch: ntsiav tshuaj: disintegrating tus neeg sawv cev
20. Cross-linked povidone: ntsiav tshuaj: disintegrant
21. Crosslinked sodium carboxymethyl cellulose: ntsiav tshuaj: disintegrating tus neeg sawv cev
22. Tsawg-siv hydroxypropyl cellulose: ntsiav tshuaj: disintegrant
23. Polylactic acid: biodegradable polymer khoom, siv rau kev npaj ntawm microspheres, nanoparticles, thiab lwm yam
24. Glycerol (sorbitol propylene glycol ua haujlwm ze rau glycerol)
Kev npaj ua kua: hnyav, tshuaj hnyav, kev ncua kev pab cuam, moisturizer
Plasticizer hauv cov tshuaj ntsiav thiab cov khoom siv txheej
Ointments, transdermal delivery systems: penetration promoters
Ua kom cov dej ntub dej ntawm cov tshuaj hydrophobic, osmotic siab regulator hauv cov hlab ntsha roj emulsion
Glycerin gelatin (rau tshuaj pleev, suppositories, khoom dispersions)
25. Glycerin gelatin
Dropping ntsiav tshuaj: dej-soluble matrix
Suppository: dej-soluble matrix
Ointment: Dej soluble matrix
26. Sodium dodecyl sulfate (anionic surfactant)
Emulsions, tshuaj pleev: emulsifiers
Tus neeg sawv cev ntub dej rau cov khoom npaj / roj nplaum rau cov ntsiav tshuaj
solubilizer
27. Polyethylene glycol (PEG)
Tablets: Dej-soluble lubricant (PEG 4000, 6000)
Tablet: Plasticizer nyob rau hauv zaj duab xis txheej tshuaj
Capsule: Mos capsule uas tsis yog roj kua nruab nrab (PEG 400)
Dropping pills: Water-soluble matrix (PEG 4000, 6000,9300)
Suppository: suppository matrix
Aerosol: Latent hnyav (PEG 400, 600)
Txhaj Tshuaj: Solvent (PEG 400, 600)
Kev npaj ua kua: kuab tshuaj (PEG 400, 600)
Khoom dispersion: carrier
Kev npaj qeeb (tswj) tso tawm: pore-inducing tus neeg sawv cev hauv microporous membrane coated ntsiav tshuaj
Percutaneous absorption npaj: transdermal absorption enhancer
28. Poloxam (" zwitterionic "surfactant) Ib tug phooj ywg ceev faj tau pom qhov tsis sib xws ntawm no, tam sim no kho rau" Poloxam "non-ionic surfactant, tsis yog zwitterionic surfactant!
Khoom dispersion carrier, suppository matrix, emulsifier rau kev txhaj tshuaj lossis infusion
Cov ntsiab lus ntawm cov tshuaj tua kab mob thiab cov kab mob bacteriostatic
Hydroxyl benzene ester (neper kub), benzoic acid, sodium benzoate, sorbic acid, benzalkonium bromide (tshiab huv), benzalkonium chloride (jie er tuag), chlorhexidine acetate, benzyl cawv (mob hauv zos) tib lub sijhawm, hla kev sib txuas. nrog tertiary butyl cawv (qhov mob hauv zos) tib lub sijhawm, nitrobenzene, mercury, thimerosal, tshuaj tua kab mob, ortho-phenyl phenol, phenoxyethanol, eucalyptus roj, cinnamon roj, peppermint roj, thiab lwm yam.
Plaub, txoj kev ua kom tsis muaj menyuam
1/ Glucose txhaj, roj emulsion rau txhaj tshuaj intravenously, dextran, sodium chloride infusion, roj hmab ntsaws thiab lwm yam kub nias kom tsis muaj menyuam;
2/ Kev txhaj tshuaj vitamin C, txhaj tshuaj procaine hydrochloride, txhaj tshuaj cortisone acetate, chloramphenicol qhov muag tee tau sterilized los ntawm circulating chav;
3/ Txhaj roj, roj matrix, ampoule siv cov cua sov kom tsis muaj menyuam;
4/ Asepsis chav cua, ua hauj lwm rooj nto: ultraviolet sterilization txoj kev los yog roj fumigation txoj kev;
5/ Tes, cov cuab yeej aseptic: chemical sterilization method
6/ Kev txhaj tshuaj insulin thiab lwm yam khoom siv lom neeg: filtration sterilization method
V. Kev sib npaug sib npaug
1. Noyes-whitney equation: piav qhia txog tus nqi dissolution ntawm cov tshuaj.
2. Qhov tseem ceeb txheeb ze av ntawm qhov sib tov
hygroscopicity ntawm P68 hmoov)
3. Hloov tus nqisuppository P87)
4.Poiseuile formula: piav qhia txog qhov cuam tshuam ntawm kev pom (txhaj tshuaj P124)
5. Kev suav cov qauv ntawm isotonic kev tswj hwm los ntawm txoj kev khov ntawm qhov txo qistxhaj tshuaj P156)
6. Kev suav ntawm HLB tus nqi sib xyaw surfactantkua P178)
Cov txheej txheem npaj tsim nyog
1. Microcapsule: condensation method (ib zaug, complex), hnyav-non-solvent method, hloov kub txoj kev, kua drying method, spray drying method, spray condensation method, air suspension method, interface condensation method, radiation crosslinking method
2. Inclusion compound: saturated aqueous tov method, sib tsoo txoj kev, freeze drying method, spray drying method
3. Solid dispersions: melting method, solvent method, solvent – melting method, hnyav – spray drying method, grinding method
4. Liposomes: txoj kev txhaj tshuaj, nyias zaj duab xis dispersion txoj kev, ultrasonic dispersion txoj kev, rov qab theem evaporation txoj kev, khov kom qhuav txoj kev
5. Microspheres: emulsification – curing method, spray drying method, kua drying method
6. Nanoparticles: micellar polymerization, emulsion polymerization, interfacial polymerization, kua ziab txoj kev
7. Pellet: boiling granulation txoj kev, tshuaj tsuag granulation txoj kev, txheej lauj kaub txoj kev, extrusion sphericity txoj kev, centrifugal projectile txoj kev, kua kom qhuav txoj kev
8 suppository: kub yaj txoj kev, txias nias txoj kev, kneading txoj kev
9. Ointment: sib tsoo txoj kev, melting txoj kev, emulsification txoj kev
10 zaj duab xis tus neeg sawv cev: homogenized slurry txaus zaj duab xis txoj kev, siab-melting zaj duab xis txoj kev, composite zaj duab xis ua txoj kev
Xya, sawv cev accessories
1. Microcapsule: gelatin – Arabic cov pos hniav
2. Inclusion compound: cyclodextrin
3. Khoom dispersion: PEG, PVP
4. Liposomes: phospholipid-cholesterol
5. Microspheres: gelatin, albumin, PLA, thiab lwm yam
6. Suppository: cocoa butter
7. Ointment: Petroleum jelly, thiab lwm yam
8 zaj duab xis tus neeg sawv cev: PVA
Yim, ob peb zaug
1. Lub ampoule sterilized yuav tsum tau tso tseg tsis pub dhau 24 teev;
2. Cia dej rau kev txhaj tshuaj yuav tsum tsis pub tshaj 12 teev;
3. Sterilization ntawm kev txhaj tshuaj yuav tsum ua kom tiav hauv 12 teev tom qab potting;
4. Infusion thiab tov npaj yuav tsum ua kom tiav nyob rau hauv 4 teev ntawm sterilization
9. Cov khoom soj ntsuam zoo muaj feem xyuam nrog kev npaj tshuaj
1. Ntsiav tshuaj: tsos yam ntxwv;Txiav qhov hnyav sib txawv;Hardness thiab brittleness;Disintegrating degree;Kev tawg lossis tso tawm;Uniformity ntawm cov ntsiab lus
2. Dispersing tus neeg sawv cev: uniformity;Moisture.Chaw thau khoom sib txawv;Kev kuaj mob;Kev tshuaj xyuas granularity
3. Granule: tsos;Particle loj;qhuav poob phaus;Qhuav;Qhov sib txawv load
4. Capsule: tsos;Moisture.Chaw thau khoom sib txawv;Disintegration thiab dissolution.
5. Cov tshuaj poob qis: qhov hnyav sib txawv;Dissolution sij hawm txwv kev soj ntsuam, thiab lwm yam.
6. Suppository: tsos;Qhov sib txawv ntawm qhov hnyav;Melting lub sij hawm txwv;Melting point ntau;Hauv vitro dissolution test thiab hauv vivo absorption test
7. Plaster: particle loj;Lub nra;Microbial txwv;Cov ntsiab lus tseem ceeb ntawm cov tshuaj;Lub cev muaj zog;Kev txhawb siab;Kev ruaj ntseg;Tso tawm, nkag mus thiab nqus cov tshuaj hauv cov tshuaj pleev.
8. Transdermal thaj ua rau thaj: qhov hnyav sib txawv;Thaj chaw sib txawv;Uniformity ntawm cov ntsiab lus;Tso degree, thiab lwm yam.
10. Cov ntsiab lus txawv
1. Micro capsule: nws yog ib qho me me capsule tsim los ntawm qhwv cov khoom siv los yog kua tshuaj (hu ua capsule core) hauv cov khoom siv hluavtaws lossis hluavtaws polymer (hu ua cov khoom siv tshuaj ntsiav).1-5000 microns
2. Pellet: yog hais txog lub cev kheej kheej uas muaj txoj kab uas hla tsawg dua 2.5 hli uas muaj cov tshuaj thiab cov khoom ntxiv.
3. Microsphere: lub cev pob txha-hom microscopic spherical qhov chaw tsim los ntawm cov tshuaj dissolving los yog dispersive tshuaj nyob rau hauv lub moj khaum ntawm cov ntaub ntawv polymer, nrog ib tug particle loj feem ntau ntawm 1 thiab 250μm.
4. Nanoparticles: khoom colloidal particles muaj li ntawm polymeric tshuaj, nrog particle loj nyob rau hauv qhov ntau ntawm 10 ~ 1000nm.
5. Dropping pill agent: yog hais txog cov khoom siv los yog kua tshuaj thiab cov khoom tsim nyog (feem ntau hu ua matrix) cua sov melting mix, poob rau hauv miscible condensate, contraction condensation thiab ua los ntawm me me pellet npaj.
Post lub sij hawm: Sep-09-2022