HPC (Hydroxypropyl Cellulose) thiab HPMC (Hydroxypropyl Methylcellulose) yog ob hom dej-soluble cellulose derivatives uas nquag siv hauv kev lag luam kws tshuaj, zaub mov thiab tshuaj lom neeg. Txawm hais tias lawv zoo sib xws hauv qee qhov, lawv cov qauv tshuaj, cov khoom thiab cov ntawv thov sib txawv yog qhov sib txawv.
1. Cov qauv tshuaj
HPC: HPC yog ib feem ntawm hydroxypropylated derivative ntawm cellulose. Nws yog tsim los ntawm reacting cellulose nrog propylene oxide thiab qhia hydroxypropyl pawg (-CH2CHOHCH3). Nyob rau hauv cov qauv ntawm HPC, ib feem ntawm cov hydroxyl pawg ntawm cov pob txha cellulose yog hloov los ntawm hydroxypropyl pawg, ua rau nws cov dej-soluble thiab thermoplastic.
HPMC: HPMC yog ib feem ntawm hydroxypropylated thiab methylated derivative ntawm cellulose. Nws yog npaj los ntawm kev qhia cov pab pawg hydroxypropyl thiab methoxy pawg (-OCH3) rau hauv cellulose. Cov qauv molecular ntawm HPMC yog qhov nyuaj dua, nrog rau ob qho tib si kev taw qhia ntawm hydroxypropyl pawg thiab methyl hloov pauv.
2. Lub cev thiab tshuaj muaj zog
Solubility: Ob qho tib si yog cov dej-soluble polymers, tab sis lawv cov cwj pwm sib txawv txawv. HPC muaj solubility zoo hauv dej txias thiab qee cov kuab tshuaj organic (xws li ethanol, propanol, thiab lwm yam), tab sis nws cov solubility yuav txo qis ntawm qhov kub siab (txog 45 ° C lossis siab dua). HPMC muaj zoo solubility nyob rau hauv dej txias, tab sis muaj gelling zog nyob rau hauv high-temperature dej, uas yog, qhov kub thiab txias, HPMC yaj nyob rau hauv dej yuav tsim ib tug gel thiab yuav tsis yaj.
Thermal stability: HPC muaj cov thermoplasticity zoo, uas txhais tau hais tias nws tuaj yeem muag los yog yaj ntawm qhov kub siab dua, yog li nws feem ntau siv rau hauv cov khoom siv thermoplastic molding. HPMC muaj kev tiv thaiv kub siab dua, tsis yooj yim rau yaj lossis muag, thiab tsim nyog rau daim ntawv thov nyob rau hauv qhov kub thiab txias.
Viscosity: HPMC feem ntau muaj viscosity siab dua HPC, tshwj xeeb tshaj yog nyob rau hauv kev lag luam kws tshuaj, HPMC feem ntau yog siv nyob rau hauv formulations uas yuav tsum tau muaj zog bonding los yog txheej, thaum HPC yog siv nyob rau hauv lub sij hawm qhov nruab nrab los yog tsawg viscosity yuav tsum tau.
3. Daim ntawv thov teb
Pharmaceutical teb:
HPC: HPC yog ib qho tshuaj excipient, feem ntau yog siv los ua cov ntsiav tshuaj nplaum, capsule plhaub zaj duab xis-ua tus neeg sawv cev, thiab cov khoom siv matrix rau kev tswj cov tshuaj. Vim nws cov thermoplasticity, nws kuj tseem tsim nyog rau qee cov txheej txheem kub yaj. HPC kuj muaj biocompatibility zoo thiab degradability, thiab yog tsim rau siv raws li ib tug intraoral tshuaj xa system.
HPMC: HPMC yog siv dav hauv kev lag luam tshuaj, thiab feem ntau yog siv los ua cov khoom siv matrix, cov khoom siv txheej, thickener thiab stabilizer rau cov ntsiav tshuaj uas tau tso tawm. Cov khoom gelling ntawm HPMC ua rau nws yog ib qho zoo tshaj plaws tshuaj tso tawm cov ntaub ntawv tswj, tshwj xeeb tshaj yog nyob rau hauv lub plab zom mov, qhov twg nws muaj peev xwm tswj tau zoo npaum li cas ntawm cov tshuaj tso tawm. Nws cov khoom ua yeeb yaj kiab zoo kuj ua rau nws qhov kev xaiv tseem ceeb rau cov ntsiav tshuaj txheej thiab particle txheej.
Zaub mov teb:
HPC: Hauv kev lag luam khoom noj khoom haus, HPC tuaj yeem siv los ua cov thickener, stabilizer thiab emulsifier los txhim kho cov kev ntxhib los mos thiab cov tsos ntawm cov zaub mov. Qee qhov xwm txheej, nws tseem tuaj yeem siv los ua cov khoom siv yeeb yaj kiab uas siv tau rau qee cov khoom noj uas yuav tsum tau khaws cia noo lossis cais tawm.
HPMC: HPMC kuj tseem siv los ua cov thickener, emulsifier thiab stabilizer hauv kev lag luam zaub mov, tshwj xeeb tshaj yog nyob rau hauv cov khoom ci xws li qhob cij thiab pastries. HPMC pab txhim kho cov qauv thiab kev ntxhib los mos ntawm lub khob noom cookie thiab txuas ntxiv lub neej txee ntawm cov zaub mov. Tsis tas li ntawd, HPMC kuj tau siv dav hauv cov khoom noj tsis noj nqaij ua cov khoom siv cog qoob loo los hloov cov tsiaj collagen.
Tshuaj pleev ib ce thiab khoom tu tus kheej:
Ob leeg HPC thiab HPMC tuaj yeem siv rau hauv cov tshuaj pleev ib ce ua cov thickeners, stabilizers thiab zaj duab xis qub. Piv txwv li, lawv tuaj yeem siv rau hauv kev tu tawv nqaij thiab cov khoom siv plaub hau los txhim kho qhov kov thiab ruaj khov ntawm cov khoom. HPMC feem ntau yog tsim nyog raws li pob tshab colloid tus neeg saib xyuas, xws li cov thickener nyob rau hauv qhov muag tee, thaum HPC feem ntau yog siv nyob rau hauv cov xwm txheej uas yuav tsum tau tsim ib tug saj zawg zog txheej.
Cov khoom siv hauv tsev thiab coatings:
HPMC: Vim nws qhov adhesion zoo thiab tuav dej, HPMC tau siv dav hauv cov khoom siv hauv tsev xws li cement, mortar, putty thiab gypsum los txhim kho adhesion thiab txhim kho kev tsim kho.
HPC: Hauv qhov sib piv, HPC tsis tshua siv nyob rau hauv kev tsim kho kev lag luam thiab feem ntau siv los ua ib qho ntxiv lossis nplaum rau cov txheej.
4. Kev nyab xeeb thiab kev tiv thaiv ib puag ncig
Ob leeg HPC thiab HPMC yog suav tias yog cov ntaub ntawv muaj kev nyab xeeb thiab siv dav hauv cov khoom noj, tshuaj thiab cov khoom tu tus kheej. Ob leeg muaj biocompatibility zoo thiab degradability, thiab yuav tsis ua rau muaj kev phom sij rau tib neeg lub cev. Txawm li cas los xij, txij li lawv tsis tau nqus hauv tib neeg lub cev thiab tsuas yog siv los ua cov khoom siv pabcuam, lawv feem ntau tsis muaj teebmeem rau tib neeg lub cev. Tsis tas li ntawd, cov txheej txheem tsim khoom ntawm HPC thiab HPMC yog ib puag ncig tus phooj ywg, thiab cov tshuaj thiab cov kuab tshuaj siv hauv kev tsim khoom tuaj yeem siv tau zoo thiab rov siv dua.
Txawm hais tias HPC thiab HPMC yog ob qho tib si cellulose derivatives thiab muaj kev sib tw hauv qee daim ntawv thov, lawv muaj qhov sib txawv loj hauv cov qauv tshuaj, lub cev thiab cov chaw siv. HPC yog qhov tsim nyog rau cov ntawv thov uas xav tau cov ntaub ntawv thermoplastic, xws li kev tswj hwm kev tso tawm ntawm cov tshuaj thiab cov txheej txheem kub yaj, thaum HPMC tau siv dav hauv cov tshuaj, khoom noj khoom haus, kev tsim kho thiab lwm yam kev lag luam vim nws qhov zoo heev adhesion, zaj duab xis-forming zog thiab dej tuav. . Yog li ntawd, cov khoom siv twg los xaiv yog nyob ntawm qhov kev thov tshwj xeeb.
Post lub sij hawm: Oct-22-2024